Anti-herpes simplex virus effects of berberine from Coptidis rhizoma, a major component of a Chinese herbal medicine, Ching-Wei-San
Berberine is an alkaloid extracted from Coptidis rhizome. Among the individual herbal components of a Chinese herb medicine, Ching-Wei-San, Coptidis Rhizoma has the most potent antimicrobial activity. By high-pressure liquid chromatography, the quantitative analysis of berberine from 6.25-mg/mL (w/v...
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| Veröffentlicht in: | Archives of virology 2010-12, Vol.155 (12), p.1933-1941 |
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| container_issue | 12 |
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| container_title | Archives of virology |
| container_volume | 155 |
| creator | Chin, Lengsu William Cheng, Yu-Wen Lin, Shih-Shen Lai, Ya-Yun Lin, Long-Yau Chou, Ming-Yung Chou, Ming-Chih Yang, Chi-Chiang |
| description | Berberine is an alkaloid extracted from Coptidis rhizome. Among the individual herbal components of a Chinese herb medicine, Ching-Wei-San, Coptidis Rhizoma has the most potent antimicrobial activity. By high-pressure liquid chromatography, the quantitative analysis of berberine from 6.25-mg/mL (w/v) Coptidis rhizome extract or 50.00-mg/mL (w/v) Ching-Wei-San was determined to be 0.26 mg/mL. To explore the potential use of Ching-Wei-San against herpes simplex virus (HSV) infection, the cytotoxicity, anti-HSV-1 and anti-HSV-2 activity in Vero cells were assayed. The selectivity index of berberine was about 1.2-1.5 times higher than that of Coptidis rhizome extract and Ching-Wei-San. Moreover, the antiviral activities correspond to the content of berberine in the aqueous solution. Berberine may interfere with the viral replication cycle after virus penetration and no later than the viral DNA synthesis step, and its activities were not affected by the preparation processes. Berberine, the natural plants that contain this component, including Coptidis rhizome, and Ching-Wei-San have all shown anti-HSV effects. |
| doi_str_mv | 10.1007/s00705-010-0779-9 |
| format | Article |
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Among the individual herbal components of a Chinese herb medicine, Ching-Wei-San, Coptidis Rhizoma has the most potent antimicrobial activity. By high-pressure liquid chromatography, the quantitative analysis of berberine from 6.25-mg/mL (w/v) Coptidis rhizome extract or 50.00-mg/mL (w/v) Ching-Wei-San was determined to be 0.26 mg/mL. To explore the potential use of Ching-Wei-San against herpes simplex virus (HSV) infection, the cytotoxicity, anti-HSV-1 and anti-HSV-2 activity in Vero cells were assayed. The selectivity index of berberine was about 1.2-1.5 times higher than that of Coptidis rhizome extract and Ching-Wei-San. Moreover, the antiviral activities correspond to the content of berberine in the aqueous solution. Berberine may interfere with the viral replication cycle after virus penetration and no later than the viral DNA synthesis step, and its activities were not affected by the preparation processes. Berberine, the natural plants that contain this component, including Coptidis rhizome, and Ching-Wei-San have all shown anti-HSV effects.</description><identifier>ISSN: 0304-8608</identifier><identifier>EISSN: 1432-8798</identifier><identifier>DOI: 10.1007/s00705-010-0779-9</identifier><identifier>PMID: 20686799</identifier><language>eng</language><publisher>Vienna: Vienna : Springer Vienna</publisher><subject>Animals ; Antimicrobial agents ; Antiviral Agents - analysis ; Antiviral Agents - isolation & purification ; Antiviral Agents - pharmacology ; Antiviral Agents - toxicity ; Bacterial infections ; Berberine - analysis ; Berberine - isolation & purification ; Berberine - pharmacology ; Berberine - toxicity ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Cercopithecus aethiops ; Chromatography ; Chromatography, High Pressure Liquid ; Cytotoxicity ; Drugs, Chinese Herbal - chemistry ; Drugs, Chinese Herbal - isolation & purification ; Drugs, Chinese Herbal - pharmacology ; Drugs, Chinese Herbal - toxicity ; Fundamental and applied biological sciences. Psychology ; Herbal medicine ; Herpes simplex virus ; Herpes viruses ; Hospitals ; Infections ; Infectious Diseases ; Medical Microbiology ; Medicine ; Microbiology ; Miscellaneous ; Original Article ; Plants, Medicinal - chemistry ; Simplexvirus - drug effects ; Vero Cells ; Viral infections ; Virology ; Virus Replication - drug effects</subject><ispartof>Archives of virology, 2010-12, Vol.155 (12), p.1933-1941</ispartof><rights>Springer-Verlag 2010</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-ea78e4f0f8feca959fb5b337d007ef09bd597613af504d0f774b1374919bef333</citedby><cites>FETCH-LOGICAL-c456t-ea78e4f0f8feca959fb5b337d007ef09bd597613af504d0f774b1374919bef333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00705-010-0779-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00705-010-0779-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23437689$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20686799$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chin, Lengsu William</creatorcontrib><creatorcontrib>Cheng, Yu-Wen</creatorcontrib><creatorcontrib>Lin, Shih-Shen</creatorcontrib><creatorcontrib>Lai, Ya-Yun</creatorcontrib><creatorcontrib>Lin, Long-Yau</creatorcontrib><creatorcontrib>Chou, Ming-Yung</creatorcontrib><creatorcontrib>Chou, Ming-Chih</creatorcontrib><creatorcontrib>Yang, Chi-Chiang</creatorcontrib><title>Anti-herpes simplex virus effects of berberine from Coptidis rhizoma, a major component of a Chinese herbal medicine, Ching-Wei-San</title><title>Archives of virology</title><addtitle>Arch Virol</addtitle><addtitle>Arch Virol</addtitle><description>Berberine is an alkaloid extracted from Coptidis rhizome. Among the individual herbal components of a Chinese herb medicine, Ching-Wei-San, Coptidis Rhizoma has the most potent antimicrobial activity. By high-pressure liquid chromatography, the quantitative analysis of berberine from 6.25-mg/mL (w/v) Coptidis rhizome extract or 50.00-mg/mL (w/v) Ching-Wei-San was determined to be 0.26 mg/mL. To explore the potential use of Ching-Wei-San against herpes simplex virus (HSV) infection, the cytotoxicity, anti-HSV-1 and anti-HSV-2 activity in Vero cells were assayed. The selectivity index of berberine was about 1.2-1.5 times higher than that of Coptidis rhizome extract and Ching-Wei-San. Moreover, the antiviral activities correspond to the content of berberine in the aqueous solution. Berberine may interfere with the viral replication cycle after virus penetration and no later than the viral DNA synthesis step, and its activities were not affected by the preparation processes. Berberine, the natural plants that contain this component, including Coptidis rhizome, and Ching-Wei-San have all shown anti-HSV effects.</description><subject>Animals</subject><subject>Antimicrobial agents</subject><subject>Antiviral Agents - analysis</subject><subject>Antiviral Agents - isolation & purification</subject><subject>Antiviral Agents - pharmacology</subject><subject>Antiviral Agents - toxicity</subject><subject>Bacterial infections</subject><subject>Berberine - analysis</subject><subject>Berberine - isolation & purification</subject><subject>Berberine - pharmacology</subject><subject>Berberine - toxicity</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cercopithecus aethiops</subject><subject>Chromatography</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Cytotoxicity</subject><subject>Drugs, Chinese Herbal - chemistry</subject><subject>Drugs, Chinese Herbal - isolation & purification</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>Drugs, Chinese Herbal - toxicity</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Herbal medicine</subject><subject>Herpes simplex virus</subject><subject>Herpes viruses</subject><subject>Hospitals</subject><subject>Infections</subject><subject>Infectious Diseases</subject><subject>Medical Microbiology</subject><subject>Medicine</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Original Article</subject><subject>Plants, Medicinal - chemistry</subject><subject>Simplexvirus - drug effects</subject><subject>Vero Cells</subject><subject>Viral infections</subject><subject>Virology</subject><subject>Virus Replication - drug effects</subject><issn>0304-8608</issn><issn>1432-8798</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkU-L1TAUxYsoznP0A7jRIIibid40SZMsh4f_YMDFOLgsaXvzXh5tU5NW1K1f3Dz7dMCFQkjg3t85uckpiscMXjIA9SrlDSQFBhSUMtTcKTZM8JJqZfTdYgMcBNUV6LPiQUoHgFzg8n5xVkKlK2XMpvhxOc6e7jFOmEjyw9TjV_LFxyURdA7bOZHgSIMxLz8icTEMZBum2Xc-kbj338NgL4glgz2ESNowTGHEcT6qLNnusyYhyf6N7cmAnW9z5eJXY0c_oafXdnxY3HO2T_jodJ4XN29ef9y-o1cf3r7fXl7RVshqpmiVRuHA6TyXNdK4Rjacqy7_AjowTSeNqhi3ToLowCklGsaVMMw06Djn58WL1XeK4fOCaa4Hn1rseztiWFKtZaWUkpL9nwQtKl4Knclnf5GHsMQxPyNDSlYVFyJDbIXaGFKK6Oop-sHGbzWD-phkvSZZ5yTrY5K1yZonJ-Olyf_2R_E7ugw8PwE2tbZ30Y6tT7ccF1xV-siVK5dya9xhvJ3wX7c_XUXOhtruYja-uS6BcWCGMSMU_wkPXb7t</recordid><startdate>20101201</startdate><enddate>20101201</enddate><creator>Chin, Lengsu William</creator><creator>Cheng, Yu-Wen</creator><creator>Lin, Shih-Shen</creator><creator>Lai, Ya-Yun</creator><creator>Lin, Long-Yau</creator><creator>Chou, Ming-Yung</creator><creator>Chou, Ming-Chih</creator><creator>Yang, Chi-Chiang</creator><general>Vienna : Springer Vienna</general><general>Springer Vienna</general><general>Springer</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20101201</creationdate><title>Anti-herpes simplex virus effects of berberine from Coptidis rhizoma, a major component of a Chinese herbal medicine, Ching-Wei-San</title><author>Chin, Lengsu William ; Cheng, Yu-Wen ; Lin, Shih-Shen ; Lai, Ya-Yun ; Lin, Long-Yau ; Chou, Ming-Yung ; Chou, Ming-Chih ; Yang, Chi-Chiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-ea78e4f0f8feca959fb5b337d007ef09bd597613af504d0f774b1374919bef333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Antimicrobial agents</topic><topic>Antiviral Agents - analysis</topic><topic>Antiviral Agents - isolation & purification</topic><topic>Antiviral Agents - pharmacology</topic><topic>Antiviral Agents - toxicity</topic><topic>Bacterial infections</topic><topic>Berberine - analysis</topic><topic>Berberine - isolation & purification</topic><topic>Berberine - pharmacology</topic><topic>Berberine - toxicity</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cercopithecus aethiops</topic><topic>Chromatography</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Cytotoxicity</topic><topic>Drugs, Chinese Herbal - chemistry</topic><topic>Drugs, Chinese Herbal - isolation & purification</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>Drugs, Chinese Herbal - toxicity</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Herbal medicine</topic><topic>Herpes simplex virus</topic><topic>Herpes viruses</topic><topic>Hospitals</topic><topic>Infections</topic><topic>Infectious Diseases</topic><topic>Medical Microbiology</topic><topic>Medicine</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Original Article</topic><topic>Plants, Medicinal - chemistry</topic><topic>Simplexvirus - drug effects</topic><topic>Vero Cells</topic><topic>Viral infections</topic><topic>Virology</topic><topic>Virus Replication - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chin, Lengsu William</creatorcontrib><creatorcontrib>Cheng, Yu-Wen</creatorcontrib><creatorcontrib>Lin, Shih-Shen</creatorcontrib><creatorcontrib>Lai, Ya-Yun</creatorcontrib><creatorcontrib>Lin, Long-Yau</creatorcontrib><creatorcontrib>Chou, Ming-Yung</creatorcontrib><creatorcontrib>Chou, Ming-Chih</creatorcontrib><creatorcontrib>Yang, Chi-Chiang</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chin, Lengsu William</au><au>Cheng, Yu-Wen</au><au>Lin, Shih-Shen</au><au>Lai, Ya-Yun</au><au>Lin, Long-Yau</au><au>Chou, Ming-Yung</au><au>Chou, Ming-Chih</au><au>Yang, Chi-Chiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-herpes simplex virus effects of berberine from Coptidis rhizoma, a major component of a Chinese herbal medicine, Ching-Wei-San</atitle><jtitle>Archives of virology</jtitle><stitle>Arch Virol</stitle><addtitle>Arch Virol</addtitle><date>2010-12-01</date><risdate>2010</risdate><volume>155</volume><issue>12</issue><spage>1933</spage><epage>1941</epage><pages>1933-1941</pages><issn>0304-8608</issn><eissn>1432-8798</eissn><abstract>Berberine is an alkaloid extracted from Coptidis rhizome. Among the individual herbal components of a Chinese herb medicine, Ching-Wei-San, Coptidis Rhizoma has the most potent antimicrobial activity. By high-pressure liquid chromatography, the quantitative analysis of berberine from 6.25-mg/mL (w/v) Coptidis rhizome extract or 50.00-mg/mL (w/v) Ching-Wei-San was determined to be 0.26 mg/mL. To explore the potential use of Ching-Wei-San against herpes simplex virus (HSV) infection, the cytotoxicity, anti-HSV-1 and anti-HSV-2 activity in Vero cells were assayed. The selectivity index of berberine was about 1.2-1.5 times higher than that of Coptidis rhizome extract and Ching-Wei-San. Moreover, the antiviral activities correspond to the content of berberine in the aqueous solution. Berberine may interfere with the viral replication cycle after virus penetration and no later than the viral DNA synthesis step, and its activities were not affected by the preparation processes. Berberine, the natural plants that contain this component, including Coptidis rhizome, and Ching-Wei-San have all shown anti-HSV effects.</abstract><cop>Vienna</cop><pub>Vienna : Springer Vienna</pub><pmid>20686799</pmid><doi>10.1007/s00705-010-0779-9</doi><tpages>9</tpages></addata></record> |
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| subjects | Animals Antimicrobial agents Antiviral Agents - analysis Antiviral Agents - isolation & purification Antiviral Agents - pharmacology Antiviral Agents - toxicity Bacterial infections Berberine - analysis Berberine - isolation & purification Berberine - pharmacology Berberine - toxicity Biological and medical sciences Biomedical and Life Sciences Biomedicine Cercopithecus aethiops Chromatography Chromatography, High Pressure Liquid Cytotoxicity Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - isolation & purification Drugs, Chinese Herbal - pharmacology Drugs, Chinese Herbal - toxicity Fundamental and applied biological sciences. Psychology Herbal medicine Herpes simplex virus Herpes viruses Hospitals Infections Infectious Diseases Medical Microbiology Medicine Microbiology Miscellaneous Original Article Plants, Medicinal - chemistry Simplexvirus - drug effects Vero Cells Viral infections Virology Virus Replication - drug effects |
| title | Anti-herpes simplex virus effects of berberine from Coptidis rhizoma, a major component of a Chinese herbal medicine, Ching-Wei-San |
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