Localization of three types of arginine vasotocin receptors in the brain and pituitary of the newt Cynops pyrrhogaster
The distribution of three types of arginine vasotocin (AVT) receptors in the brain and pituitary of the newt Cynops pyrrhogaster , namely, the V1a-, V2-, and V3/V1b-type receptors, was studied by means of in situ hybridization and immunohistochemistry. mRNA signals and immunoreactive cells for the V...
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| Veröffentlicht in: | Cell and tissue research 2010-12, Vol.342 (3), p.437-457 |
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| creator | Hasunuma, Itaru Toyoda, Fumiyo Kadono, Yoshihiko Yamamoto, Kazutoshi Namiki, Hideo Kikuyama, Sakae |
| description | The distribution of three types of arginine vasotocin (AVT) receptors in the brain and pituitary of the newt
Cynops pyrrhogaster
, namely, the V1a-, V2-, and V3/V1b-type receptors, was studied by means of in situ hybridization and immunohistochemistry. mRNA signals and immunoreactive cells for the V1a-type receptor were observed in the telencephalon (mitral layer of the olfactory bulb, dorsal and medial pallium, lateral and medial amygdala, bed nucleus of the decussation of the fasciculus telencephali, bed nucleus of the stria terminalis), diencephalon (anterior preoptic area, magnocellular preoptic nucleus, suprachiasmatic nucleus, ventral thalamus, dorsal and ventral hypothalamic nucleus), mesencephalon (tegmentum, interpeduncular nucleus), and medulla oblongata (median reticular formation, nucleus motorius tegmenti). Cells expressing the V2-type receptor were found in the telencephalon (medial pallium, lateral and medial amygdala, bed nucleus of the decussation of the fasciculus telencephali), and mesencephalon (tegmentum trigemini and facialis). In the paraphysis (possibly the main site of cerebrospinal fluid production), only V2-type receptor mRNA signal and immunoreactivity were detected. V3/V1b-type receptor mRNA was expressed in the diencephalon (dorsal hypothalamic nucleus, nucleus tuberculi posterioris), mesencephalon (tegmentum, interpeduncular nucleus), and medulla oblongata (raphe nucleus), whereas V3/V1b-type-receptor-like immunoreactivity was scarcely detectable in the entire brain. The V3/V1b-type receptor was predominantly expressed in the anterior pituitary. V3/V1b-type receptor and proopiomelanocortin mRNAs were co-localized in the distal lobe of the pituitary. This is the first report of the distribution of three types of AVT receptor in the brain and pituitary of non-mammalian vertebrates. |
| doi_str_mv | 10.1007/s00441-010-1079-0 |
| format | Article |
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Cynops pyrrhogaster
, namely, the V1a-, V2-, and V3/V1b-type receptors, was studied by means of in situ hybridization and immunohistochemistry. mRNA signals and immunoreactive cells for the V1a-type receptor were observed in the telencephalon (mitral layer of the olfactory bulb, dorsal and medial pallium, lateral and medial amygdala, bed nucleus of the decussation of the fasciculus telencephali, bed nucleus of the stria terminalis), diencephalon (anterior preoptic area, magnocellular preoptic nucleus, suprachiasmatic nucleus, ventral thalamus, dorsal and ventral hypothalamic nucleus), mesencephalon (tegmentum, interpeduncular nucleus), and medulla oblongata (median reticular formation, nucleus motorius tegmenti). Cells expressing the V2-type receptor were found in the telencephalon (medial pallium, lateral and medial amygdala, bed nucleus of the decussation of the fasciculus telencephali), and mesencephalon (tegmentum trigemini and facialis). In the paraphysis (possibly the main site of cerebrospinal fluid production), only V2-type receptor mRNA signal and immunoreactivity were detected. V3/V1b-type receptor mRNA was expressed in the diencephalon (dorsal hypothalamic nucleus, nucleus tuberculi posterioris), mesencephalon (tegmentum, interpeduncular nucleus), and medulla oblongata (raphe nucleus), whereas V3/V1b-type-receptor-like immunoreactivity was scarcely detectable in the entire brain. The V3/V1b-type receptor was predominantly expressed in the anterior pituitary. V3/V1b-type receptor and proopiomelanocortin mRNAs were co-localized in the distal lobe of the pituitary. This is the first report of the distribution of three types of AVT receptor in the brain and pituitary of non-mammalian vertebrates.</description><identifier>ISSN: 0302-766X</identifier><identifier>EISSN: 1432-0878</identifier><identifier>DOI: 10.1007/s00441-010-1079-0</identifier><identifier>PMID: 21079998</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Amphibians ; Animals ; Arginine ; Biomedical and Life Sciences ; Biomedicine ; Brain ; Brain Chemistry ; Cynops pyrrhogaster ; Diencephalon - chemistry ; Diencephalon - cytology ; Fluorescent Antibody Technique ; Human Genetics ; Immunohistochemistry ; In Situ Hybridization ; Intermedin ; Medulla Oblongata - chemistry ; Medulla Oblongata - cytology ; Mesencephalon - chemistry ; Mesencephalon - cytology ; Molecular Medicine ; Neurons ; Pituitary Gland, Anterior - chemistry ; Pituitary Gland, Anterior - cytology ; Polymerase Chain Reaction ; Proteomics ; Receptors, Vasopressin - analysis ; Receptors, Vasopressin - isolation & purification ; Regular Article ; RNA ; RNA, Messenger ; Salamandridae ; Salamandridae - metabolism ; Signal Transduction ; Telencephalon - chemistry ; Telencephalon - cytology</subject><ispartof>Cell and tissue research, 2010-12, Vol.342 (3), p.437-457</ispartof><rights>Springer-Verlag 2010</rights><rights>COPYRIGHT 2010 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c566t-c61568503179b65ff63bd86f164a5f6ddc6bb3d55b2101e0376f294da3036a8f3</citedby><cites>FETCH-LOGICAL-c566t-c61568503179b65ff63bd86f164a5f6ddc6bb3d55b2101e0376f294da3036a8f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00441-010-1079-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00441-010-1079-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21079998$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hasunuma, Itaru</creatorcontrib><creatorcontrib>Toyoda, Fumiyo</creatorcontrib><creatorcontrib>Kadono, Yoshihiko</creatorcontrib><creatorcontrib>Yamamoto, Kazutoshi</creatorcontrib><creatorcontrib>Namiki, Hideo</creatorcontrib><creatorcontrib>Kikuyama, Sakae</creatorcontrib><title>Localization of three types of arginine vasotocin receptors in the brain and pituitary of the newt Cynops pyrrhogaster</title><title>Cell and tissue research</title><addtitle>Cell Tissue Res</addtitle><addtitle>Cell Tissue Res</addtitle><description>The distribution of three types of arginine vasotocin (AVT) receptors in the brain and pituitary of the newt
Cynops pyrrhogaster
, namely, the V1a-, V2-, and V3/V1b-type receptors, was studied by means of in situ hybridization and immunohistochemistry. mRNA signals and immunoreactive cells for the V1a-type receptor were observed in the telencephalon (mitral layer of the olfactory bulb, dorsal and medial pallium, lateral and medial amygdala, bed nucleus of the decussation of the fasciculus telencephali, bed nucleus of the stria terminalis), diencephalon (anterior preoptic area, magnocellular preoptic nucleus, suprachiasmatic nucleus, ventral thalamus, dorsal and ventral hypothalamic nucleus), mesencephalon (tegmentum, interpeduncular nucleus), and medulla oblongata (median reticular formation, nucleus motorius tegmenti). Cells expressing the V2-type receptor were found in the telencephalon (medial pallium, lateral and medial amygdala, bed nucleus of the decussation of the fasciculus telencephali), and mesencephalon (tegmentum trigemini and facialis). In the paraphysis (possibly the main site of cerebrospinal fluid production), only V2-type receptor mRNA signal and immunoreactivity were detected. V3/V1b-type receptor mRNA was expressed in the diencephalon (dorsal hypothalamic nucleus, nucleus tuberculi posterioris), mesencephalon (tegmentum, interpeduncular nucleus), and medulla oblongata (raphe nucleus), whereas V3/V1b-type-receptor-like immunoreactivity was scarcely detectable in the entire brain. The V3/V1b-type receptor was predominantly expressed in the anterior pituitary. V3/V1b-type receptor and proopiomelanocortin mRNAs were co-localized in the distal lobe of the pituitary. This is the first report of the distribution of three types of AVT receptor in the brain and pituitary of non-mammalian vertebrates.</description><subject>Amphibians</subject><subject>Animals</subject><subject>Arginine</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain</subject><subject>Brain Chemistry</subject><subject>Cynops pyrrhogaster</subject><subject>Diencephalon - chemistry</subject><subject>Diencephalon - cytology</subject><subject>Fluorescent Antibody Technique</subject><subject>Human Genetics</subject><subject>Immunohistochemistry</subject><subject>In Situ Hybridization</subject><subject>Intermedin</subject><subject>Medulla Oblongata - chemistry</subject><subject>Medulla Oblongata - cytology</subject><subject>Mesencephalon - chemistry</subject><subject>Mesencephalon - cytology</subject><subject>Molecular Medicine</subject><subject>Neurons</subject><subject>Pituitary Gland, Anterior - chemistry</subject><subject>Pituitary Gland, Anterior - cytology</subject><subject>Polymerase Chain Reaction</subject><subject>Proteomics</subject><subject>Receptors, Vasopressin - analysis</subject><subject>Receptors, Vasopressin - isolation & purification</subject><subject>Regular Article</subject><subject>RNA</subject><subject>RNA, Messenger</subject><subject>Salamandridae</subject><subject>Salamandridae - metabolism</subject><subject>Signal Transduction</subject><subject>Telencephalon - chemistry</subject><subject>Telencephalon - cytology</subject><issn>0302-766X</issn><issn>1432-0878</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkl2L1DAUhoMo7jj6A7yRoKBXXZPmo-3lMuyqMOCNgnchbU-mWTpJTdKV8deb2vVjRZEEkpM85-W8nIPQU0rOKSHV60gI57QglBSUVE1B7qEN5awsSF3V99GGMFIWlZSfztCjGK8JoVzK5iE6Kxe8aeoNutn7To_2q07WO-wNTkMAwOk0QVxCHQ7WWQf4RkeffGcdDtDBlHyIOAdpANwGnW_a9XiyabZJh9OqBNjBl4R3J-eniKdTCIM_6JggPEYPjB4jPLk9t-jj1eWH3dti__7Nu93FvuiElKnoJBWyFoTRqmmlMEaytq-loZJrYWTfd7JtWS9Emx1RIKySpmx4rxlhUteGbdGrVXcK_vMMMamjjR2Mo3bg56hqIasqb_5_kopGclZXmXz-B3nt5-CyjQUSoilzwVv0YoUOegRlnfEp6G6RVBdM8Fo0nMlMnf-FyquHo-28A2Pz-52El78lDKDHNEQ_zkv34l2QrmAXfIwBjJqCPebOKErUMjxqHR5FvsdVo5aan90am9sj9D8zfkxLBsoViPnLHSD8cv5v1W-6q82H</recordid><startdate>20101201</startdate><enddate>20101201</enddate><creator>Hasunuma, Itaru</creator><creator>Toyoda, Fumiyo</creator><creator>Kadono, Yoshihiko</creator><creator>Yamamoto, Kazutoshi</creator><creator>Namiki, Hideo</creator><creator>Kikuyama, Sakae</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7SS</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope></search><sort><creationdate>20101201</creationdate><title>Localization of three types of arginine vasotocin receptors in the brain and pituitary of the newt Cynops pyrrhogaster</title><author>Hasunuma, Itaru ; Toyoda, Fumiyo ; Kadono, Yoshihiko ; Yamamoto, Kazutoshi ; Namiki, Hideo ; Kikuyama, Sakae</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c566t-c61568503179b65ff63bd86f164a5f6ddc6bb3d55b2101e0376f294da3036a8f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Amphibians</topic><topic>Animals</topic><topic>Arginine</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain</topic><topic>Brain Chemistry</topic><topic>Cynops pyrrhogaster</topic><topic>Diencephalon - chemistry</topic><topic>Diencephalon - cytology</topic><topic>Fluorescent Antibody Technique</topic><topic>Human Genetics</topic><topic>Immunohistochemistry</topic><topic>In Situ Hybridization</topic><topic>Intermedin</topic><topic>Medulla Oblongata - chemistry</topic><topic>Medulla Oblongata - cytology</topic><topic>Mesencephalon - chemistry</topic><topic>Mesencephalon - cytology</topic><topic>Molecular Medicine</topic><topic>Neurons</topic><topic>Pituitary Gland, Anterior - chemistry</topic><topic>Pituitary Gland, Anterior - cytology</topic><topic>Polymerase Chain Reaction</topic><topic>Proteomics</topic><topic>Receptors, Vasopressin - analysis</topic><topic>Receptors, Vasopressin - isolation & purification</topic><topic>Regular Article</topic><topic>RNA</topic><topic>RNA, Messenger</topic><topic>Salamandridae</topic><topic>Salamandridae - metabolism</topic><topic>Signal Transduction</topic><topic>Telencephalon - chemistry</topic><topic>Telencephalon - cytology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hasunuma, Itaru</creatorcontrib><creatorcontrib>Toyoda, Fumiyo</creatorcontrib><creatorcontrib>Kadono, Yoshihiko</creatorcontrib><creatorcontrib>Yamamoto, Kazutoshi</creatorcontrib><creatorcontrib>Namiki, Hideo</creatorcontrib><creatorcontrib>Kikuyama, Sakae</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><jtitle>Cell and tissue research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hasunuma, Itaru</au><au>Toyoda, Fumiyo</au><au>Kadono, Yoshihiko</au><au>Yamamoto, Kazutoshi</au><au>Namiki, Hideo</au><au>Kikuyama, Sakae</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Localization of three types of arginine vasotocin receptors in the brain and pituitary of the newt Cynops pyrrhogaster</atitle><jtitle>Cell and tissue research</jtitle><stitle>Cell Tissue Res</stitle><addtitle>Cell Tissue Res</addtitle><date>2010-12-01</date><risdate>2010</risdate><volume>342</volume><issue>3</issue><spage>437</spage><epage>457</epage><pages>437-457</pages><issn>0302-766X</issn><eissn>1432-0878</eissn><abstract>The distribution of three types of arginine vasotocin (AVT) receptors in the brain and pituitary of the newt
Cynops pyrrhogaster
, namely, the V1a-, V2-, and V3/V1b-type receptors, was studied by means of in situ hybridization and immunohistochemistry. mRNA signals and immunoreactive cells for the V1a-type receptor were observed in the telencephalon (mitral layer of the olfactory bulb, dorsal and medial pallium, lateral and medial amygdala, bed nucleus of the decussation of the fasciculus telencephali, bed nucleus of the stria terminalis), diencephalon (anterior preoptic area, magnocellular preoptic nucleus, suprachiasmatic nucleus, ventral thalamus, dorsal and ventral hypothalamic nucleus), mesencephalon (tegmentum, interpeduncular nucleus), and medulla oblongata (median reticular formation, nucleus motorius tegmenti). Cells expressing the V2-type receptor were found in the telencephalon (medial pallium, lateral and medial amygdala, bed nucleus of the decussation of the fasciculus telencephali), and mesencephalon (tegmentum trigemini and facialis). In the paraphysis (possibly the main site of cerebrospinal fluid production), only V2-type receptor mRNA signal and immunoreactivity were detected. V3/V1b-type receptor mRNA was expressed in the diencephalon (dorsal hypothalamic nucleus, nucleus tuberculi posterioris), mesencephalon (tegmentum, interpeduncular nucleus), and medulla oblongata (raphe nucleus), whereas V3/V1b-type-receptor-like immunoreactivity was scarcely detectable in the entire brain. The V3/V1b-type receptor was predominantly expressed in the anterior pituitary. V3/V1b-type receptor and proopiomelanocortin mRNAs were co-localized in the distal lobe of the pituitary. This is the first report of the distribution of three types of AVT receptor in the brain and pituitary of non-mammalian vertebrates.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>21079998</pmid><doi>10.1007/s00441-010-1079-0</doi><tpages>21</tpages></addata></record> |
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| ispartof | Cell and tissue research, 2010-12, Vol.342 (3), p.437-457 |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Amphibians Animals Arginine Biomedical and Life Sciences Biomedicine Brain Brain Chemistry Cynops pyrrhogaster Diencephalon - chemistry Diencephalon - cytology Fluorescent Antibody Technique Human Genetics Immunohistochemistry In Situ Hybridization Intermedin Medulla Oblongata - chemistry Medulla Oblongata - cytology Mesencephalon - chemistry Mesencephalon - cytology Molecular Medicine Neurons Pituitary Gland, Anterior - chemistry Pituitary Gland, Anterior - cytology Polymerase Chain Reaction Proteomics Receptors, Vasopressin - analysis Receptors, Vasopressin - isolation & purification Regular Article RNA RNA, Messenger Salamandridae Salamandridae - metabolism Signal Transduction Telencephalon - chemistry Telencephalon - cytology |
| title | Localization of three types of arginine vasotocin receptors in the brain and pituitary of the newt Cynops pyrrhogaster |
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