Characterization of Developmental Neurotoxicity of As, Cd, and Pb Mixture: Synergistic Action of Metal Mixture in Glial and Neuronal Functions

Neurotoxicity of individual metals is well investigated but that of metal mixture (MM), an environmental reality, in the developing brain is relatively obscure. We investigated the combinatorial effect of arsenic (As), cadmium (Cd), and lead (Pb) on rat brain development, spanning in utero to postna...

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Veröffentlicht in:	Toxicological sciences 2010-12, Vol.118 (2), p.586-601
Hauptverfasser:	Rai, Asit, Maurya, Shailendra Kr, Khare, Priyanka, Srivastava, Abhinav, Bandyopadhyay, Sanghamitra
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn apoptosis Apoptosis - drug effects Arsenites - toxicity Astrocytes - drug effects Astrocytes - pathology Behavior, Animal - drug effects Behavior, Animal - physiology Brain - drug effects Brain - embryology Brain - physiology brain damage Cadmium Chloride - toxicity Cell Survival - drug effects Complex Mixtures Drug Combinations Drug Synergism environment Environmental Pollutants - toxicity Female GFAP Hand Strength Lactation - drug effects Locomotion - drug effects Maternal Exposure - adverse effects Maze Learning - drug effects metal toxicants Metals, Heavy - toxicity Nervous System Diseases - chemically induced Nervous System Diseases - pathology Neurons - drug effects Neurons - pathology Organometallic Compounds - toxicity Pregnancy Rats Rats, Wistar Sodium Compounds - toxicity
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