Genomic profiling of high-risk acute lymphoblastic leukemia
Acute lymphoblastic leukemia (ALL) is a heterogeneous disease comprising multiple subtypes with different genetic alterations and responses to therapy. Recent genome-wide profiling studies of ALL have identified a number of novel genetic alterations that target key cellular pathways in lymphoid grow...
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| Veröffentlicht in: | Leukemia 2010-10, Vol.24 (10), p.1676-1685 |
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| description | Acute lymphoblastic leukemia (ALL) is a heterogeneous disease comprising multiple subtypes with different genetic alterations and responses to therapy. Recent genome-wide profiling studies of ALL have identified a number of novel genetic alterations that target key cellular pathways in lymphoid growth and differentiation and are associated with treatment outcome. Notably, genetic alteration of the lymphoid transcription factor gene
IKZF1
is a hallmark of multiple subtypes of ALL with poor prognosis, including
BCR-ABL1
-positive lymphoid leukemia and a subset of ‘BCR-ABL1-like’ ALL cases that, in addition to
IKZF1
alteration, harbor genetic mutations resulting in aberrant lymphoid cytokine receptor signaling, including activating mutations of Janus kinases and rearrangement of cytokine receptor-like factor 2 (
CRLF2
). Recent insights from genome-wide profiling studies of B-progenitor ALL and the potential for new therapeutic approaches in high-risk disease are discussed. |
| doi_str_mv | 10.1038/leu.2010.177 |
| format | Article |
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IKZF1
is a hallmark of multiple subtypes of ALL with poor prognosis, including
BCR-ABL1
-positive lymphoid leukemia and a subset of ‘BCR-ABL1-like’ ALL cases that, in addition to
IKZF1
alteration, harbor genetic mutations resulting in aberrant lymphoid cytokine receptor signaling, including activating mutations of Janus kinases and rearrangement of cytokine receptor-like factor 2 (
CRLF2
). Recent insights from genome-wide profiling studies of B-progenitor ALL and the potential for new therapeutic approaches in high-risk disease are discussed.</description><identifier>ISSN: 0887-6924</identifier><identifier>EISSN: 1476-5551</identifier><identifier>DOI: 10.1038/leu.2010.177</identifier><identifier>PMID: 20739952</identifier><identifier>CODEN: LEUKED</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/208/191/2018 ; 692/699/67/1990/283/2125 ; 692/700/1750 ; Acute lymphoblastic leukemia ; Acute lymphocytic leukemia ; Adults ; Arrays ; BCR-ABL protein ; Biological and medical sciences ; Biomarkers, Tumor - genetics ; Biomarkers, Tumor - metabolism ; Cancer Research ; Care and treatment ; Cell cycle ; Critical Care Medicine ; Cytokines ; Gene Expression Profiling ; Gene mutations ; Genes ; Genetic aspects ; Genome, Human ; Genomes ; Genomics ; Health aspects ; Health risks ; Hematologic and hematopoietic diseases ; Hematology ; Humans ; Intensive ; Internal Medicine ; Kinases ; Leukemia ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphatic leukemia ; Medical sciences ; Medicine ; Medicine & Public Health ; Mutation ; Oligonucleotide Array Sequence Analysis ; Oncology ; Pediatrics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology ; Receptors ; review ; Risk Factors ; Signal Transduction ; Transcription factors</subject><ispartof>Leukemia, 2010-10, Vol.24 (10), p.1676-1685</ispartof><rights>Macmillan Publishers Limited 2010</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2010 Nature Publishing Group</rights><rights>Macmillan Publishers Limited 2010.</rights><rights>Copyright Nature Publishing Group Oct 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-dc34ae3e3bdba11c4e77fead998987ccd81fa11aa0f99210b6cf1935e97168f43</citedby><cites>FETCH-LOGICAL-c504t-dc34ae3e3bdba11c4e77fead998987ccd81fa11aa0f99210b6cf1935e97168f43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/leu.2010.177$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/leu.2010.177$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23336679$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20739952$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Collins-Underwood, J R</creatorcontrib><creatorcontrib>Mullighan, C G</creatorcontrib><title>Genomic profiling of high-risk acute lymphoblastic leukemia</title><title>Leukemia</title><addtitle>Leukemia</addtitle><addtitle>Leukemia</addtitle><description>Acute lymphoblastic leukemia (ALL) is a heterogeneous disease comprising multiple subtypes with different genetic alterations and responses to therapy. Recent genome-wide profiling studies of ALL have identified a number of novel genetic alterations that target key cellular pathways in lymphoid growth and differentiation and are associated with treatment outcome. Notably, genetic alteration of the lymphoid transcription factor gene
IKZF1
is a hallmark of multiple subtypes of ALL with poor prognosis, including
BCR-ABL1
-positive lymphoid leukemia and a subset of ‘BCR-ABL1-like’ ALL cases that, in addition to
IKZF1
alteration, harbor genetic mutations resulting in aberrant lymphoid cytokine receptor signaling, including activating mutations of Janus kinases and rearrangement of cytokine receptor-like factor 2 (
CRLF2
). Recent insights from genome-wide profiling studies of B-progenitor ALL and the potential for new therapeutic approaches in high-risk disease are discussed.</description><subject>631/208/191/2018</subject><subject>692/699/67/1990/283/2125</subject><subject>692/700/1750</subject><subject>Acute lymphoblastic leukemia</subject><subject>Acute lymphocytic leukemia</subject><subject>Adults</subject><subject>Arrays</subject><subject>BCR-ABL protein</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Cancer Research</subject><subject>Care and treatment</subject><subject>Cell cycle</subject><subject>Critical Care Medicine</subject><subject>Cytokines</subject><subject>Gene Expression Profiling</subject><subject>Gene mutations</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genome, Human</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematology</subject><subject>Humans</subject><subject>Intensive</subject><subject>Internal Medicine</subject><subject>Kinases</subject><subject>Leukemia</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphatic leukemia</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mutation</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Oncology</subject><subject>Pediatrics</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology</subject><subject>Receptors</subject><subject>review</subject><subject>Risk Factors</subject><subject>Signal Transduction</subject><subject>Transcription factors</subject><issn>0887-6924</issn><issn>1476-5551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqF0ctrFDEYAPAgil2rN88yKNaLU_N-4KmUWoWCFz2HTCbZSZuZrMnMof-9GXZ1VRRPIfl-5HsB8BzBcwSJfBfdco7hehPiAdggKnjLGEMPwQZKKVquMD0BT0q5hXAN8sfgBENBlGJ4A95fuymNwTa7nHyIYdo2yTdD2A5tDuWuMXaZXRPvx92QumjKXGnNeOfGYJ6CR97E4p4dzlPw9cPVl8uP7c3n60-XFzetZZDObW8JNY440vWdQchSJ4R3pldKKims7SXy9d0Y6JXCCHbceqQIc0ogLj0lp-DN_t9a47fFlVmPoVgXo5lcWoqWjAtBuUT_lYJVhJUSVb78Q96mJU-1jYqEhBITXtGrfyHMKRNYScSOamui02Hyac7Gron1BaZ16IIQXNXZL2pwJs5DSXGZQ5rK7_DtHtqcSsnO610Oo8n3GkG9blzX-et147puvPIXhxqXbnT9T_xjxRW8PgBTrIk-m8mGcnSEEM6Fqq7du1JD09blY7N_Tfwdx8K-kg</recordid><startdate>20101001</startdate><enddate>20101001</enddate><creator>Collins-Underwood, J R</creator><creator>Mullighan, C G</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>RC3</scope></search><sort><creationdate>20101001</creationdate><title>Genomic profiling of high-risk acute lymphoblastic leukemia</title><author>Collins-Underwood, J R ; Mullighan, C G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c504t-dc34ae3e3bdba11c4e77fead998987ccd81fa11aa0f99210b6cf1935e97168f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>631/208/191/2018</topic><topic>692/699/67/1990/283/2125</topic><topic>692/700/1750</topic><topic>Acute lymphoblastic leukemia</topic><topic>Acute lymphocytic leukemia</topic><topic>Adults</topic><topic>Arrays</topic><topic>BCR-ABL protein</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Cancer Research</topic><topic>Care and treatment</topic><topic>Cell cycle</topic><topic>Critical Care Medicine</topic><topic>Cytokines</topic><topic>Gene Expression Profiling</topic><topic>Gene mutations</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genome, Human</topic><topic>Genomes</topic><topic>Genomics</topic><topic>Health aspects</topic><topic>Health risks</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hematology</topic><topic>Humans</topic><topic>Intensive</topic><topic>Internal Medicine</topic><topic>Kinases</topic><topic>Leukemia</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphatic leukemia</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mutation</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>Oncology</topic><topic>Pediatrics</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology</topic><topic>Receptors</topic><topic>review</topic><topic>Risk Factors</topic><topic>Signal Transduction</topic><topic>Transcription factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Collins-Underwood, J R</creatorcontrib><creatorcontrib>Mullighan, C G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Genetics Abstracts</collection><jtitle>Leukemia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Collins-Underwood, J R</au><au>Mullighan, C G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genomic profiling of high-risk acute lymphoblastic leukemia</atitle><jtitle>Leukemia</jtitle><stitle>Leukemia</stitle><addtitle>Leukemia</addtitle><date>2010-10-01</date><risdate>2010</risdate><volume>24</volume><issue>10</issue><spage>1676</spage><epage>1685</epage><pages>1676-1685</pages><issn>0887-6924</issn><eissn>1476-5551</eissn><coden>LEUKED</coden><abstract>Acute lymphoblastic leukemia (ALL) is a heterogeneous disease comprising multiple subtypes with different genetic alterations and responses to therapy. Recent genome-wide profiling studies of ALL have identified a number of novel genetic alterations that target key cellular pathways in lymphoid growth and differentiation and are associated with treatment outcome. Notably, genetic alteration of the lymphoid transcription factor gene
IKZF1
is a hallmark of multiple subtypes of ALL with poor prognosis, including
BCR-ABL1
-positive lymphoid leukemia and a subset of ‘BCR-ABL1-like’ ALL cases that, in addition to
IKZF1
alteration, harbor genetic mutations resulting in aberrant lymphoid cytokine receptor signaling, including activating mutations of Janus kinases and rearrangement of cytokine receptor-like factor 2 (
CRLF2
). Recent insights from genome-wide profiling studies of B-progenitor ALL and the potential for new therapeutic approaches in high-risk disease are discussed.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>20739952</pmid><doi>10.1038/leu.2010.177</doi><tpages>10</tpages></addata></record> |
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| subjects | 631/208/191/2018 692/699/67/1990/283/2125 692/700/1750 Acute lymphoblastic leukemia Acute lymphocytic leukemia Adults Arrays BCR-ABL protein Biological and medical sciences Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cancer Research Care and treatment Cell cycle Critical Care Medicine Cytokines Gene Expression Profiling Gene mutations Genes Genetic aspects Genome, Human Genomes Genomics Health aspects Health risks Hematologic and hematopoietic diseases Hematology Humans Intensive Internal Medicine Kinases Leukemia Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphatic leukemia Medical sciences Medicine Medicine & Public Health Mutation Oligonucleotide Array Sequence Analysis Oncology Pediatrics Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology Receptors review Risk Factors Signal Transduction Transcription factors |
| title | Genomic profiling of high-risk acute lymphoblastic leukemia |
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