Iterative Stereospecific Reagent-Controlled Homologation Using a Functionalized α-Chloroalkyllithium: Synthesis of Cyclic Targets Related to Epibatidine

Enantioenriched 1-chloro-2-(1,3-dioxolan-2-yl)ethyllithium was generated by PhLi initiated sulfoxide-ligand exchange and deployed in situ for sequential double stereospecific reagent-controlled homologation (StReCH) of B-(2-chloro-pyrid-5-yl) pinacol boronate. This process afforded highly functional...

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Veröffentlicht in:	Organic letters 2011-03, Vol.13 (6), p.1318-1321
Hauptverfasser:	Emerson, Christopher R, Zakharov, Lev N, Blakemore, Paul R
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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