Roles of putative His-to-Asp signaling modules HPT-1 and RRG-2, on viability and sensitivity to osmotic and oxidative stresses in Neurospora crassa
Neurospora crassa has a putative histidine phosphotransfer protein (HPT-1) that transfers signals from 11 histidine kinases to two putative response regulators (RRG-1 and RRG-2) in its histidine-to-aspartate phosphorelay system. The hpt-1 gene was successfully disrupted in the os-2 (MAP kinase gene)...
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| Veröffentlicht in: | Current genetics 2007-03, Vol.51 (3), p.197-208 |
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| creator | Banno, Shinpei Noguchi, Rieko Yamashita, Kazuhiro Fukumori, Fumiyasu Kimura, Makoto Yamaguchi, Isamu Fujimura, Makoto |
| description | Neurospora crassa has a putative histidine phosphotransfer protein (HPT-1) that transfers signals from 11 histidine kinases to two putative response regulators (RRG-1 and RRG-2) in its histidine-to-aspartate phosphorelay system. The hpt-1 gene was successfully disrupted in the os-2 (MAP kinase gene) mutant, but not in the wild-type strain in this study. Crossing the resultant hpt-1; os-2 mutants with the wild-type or os-1 (histidine kinase gene) mutant strains produced no progeny with hpt-1 or os-1; hpt-1 mutation, strongly suggesting that hpt-1 is essential for growth unless downstream OS-2 is inactivated. hpt-1 mutation partially recovered the osmotic sensitivity of os-2 mutants, implying the involvement of yeast Skn7-like RRG-2 in osmoregulation. However, the rrg-2 disruption did not change the osmotic sensitivity of the wild-type strain and the os-2 mutant, suggesting that rrg-2 did not participate in the osmoregulation. Both rrg-2 and os-2 single mutation slightly increased sensitivity to t-butyl hydroperoxide, and rrg-2 and hpt-1 mutations increased the os-2 mutant's sensitivity. Although OS-1 is considered as a positive regulator of OS-2 MAP kinase, our results suggested that HPT-1 negatively regulated downstream MAP kinase cascade, and that OS-2 and RRG-2 probably participate independently in the oxidative stress response in N. crassa. |
| doi_str_mv | 10.1007/s00294-006-0116-8 |
| format | Article |
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The hpt-1 gene was successfully disrupted in the os-2 (MAP kinase gene) mutant, but not in the wild-type strain in this study. Crossing the resultant hpt-1; os-2 mutants with the wild-type or os-1 (histidine kinase gene) mutant strains produced no progeny with hpt-1 or os-1; hpt-1 mutation, strongly suggesting that hpt-1 is essential for growth unless downstream OS-2 is inactivated. hpt-1 mutation partially recovered the osmotic sensitivity of os-2 mutants, implying the involvement of yeast Skn7-like RRG-2 in osmoregulation. However, the rrg-2 disruption did not change the osmotic sensitivity of the wild-type strain and the os-2 mutant, suggesting that rrg-2 did not participate in the osmoregulation. Both rrg-2 and os-2 single mutation slightly increased sensitivity to t-butyl hydroperoxide, and rrg-2 and hpt-1 mutations increased the os-2 mutant's sensitivity. Although OS-1 is considered as a positive regulator of OS-2 MAP kinase, our results suggested that HPT-1 negatively regulated downstream MAP kinase cascade, and that OS-2 and RRG-2 probably participate independently in the oxidative stress response in N. crassa.</description><identifier>ISSN: 0172-8083</identifier><identifier>EISSN: 1432-0983</identifier><identifier>DOI: 10.1007/s00294-006-0116-8</identifier><identifier>PMID: 17211673</identifier><language>eng</language><publisher>United States: Berlin/Heidelberg : Springer-Verlag</publisher><subject>Amino Acid Motifs - genetics ; Amino Acid Sequence ; Amino Acid Substitution - genetics ; Aminoimidazole Carboxamide - analogs & derivatives ; Aminoimidazole Carboxamide - pharmacology ; Aspartic Acid - genetics ; Aspartic Acid - physiology ; Butyl hydroperoxide ; Fungal Proteins - genetics ; Fungal Proteins - physiology ; Fungicides, Industrial - pharmacology ; Genetic crosses ; Histidine ; Histidine - genetics ; Histidine - physiology ; Histidine Kinase ; Histidine phosphotransfer ; Hydantoins - pharmacology ; MAP kinase ; Mitogen-Activated Protein Kinases - genetics ; Mitogen-Activated Protein Kinases - physiology ; Molecular Sequence Data ; Mutants ; Mutation ; Neurospora crassa ; Neurospora crassa - drug effects ; Neurospora crassa - genetics ; Neurospora crassa - growth & development ; Neurospora crassa - physiology ; Osmoregulation ; Osmotic Pressure - drug effects ; Oxidative stress ; Oxidative Stress - drug effects ; Oxidative Stress - genetics ; Oxidative Stress - physiology ; Point Mutation ; Protein Kinases - genetics ; Response regulator ; Signal Transduction - drug effects ; Signal Transduction - genetics ; Signal Transduction - physiology ; Two-component signal transduction ; Yeasts</subject><ispartof>Current genetics, 2007-03, Vol.51 (3), p.197-208</ispartof><rights>Springer-Verlag 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-349939e05a9121bdaba67be005c8842e126b40ee64b09010fa3a55d5f1e7f93d3</citedby><cites>FETCH-LOGICAL-c448t-349939e05a9121bdaba67be005c8842e126b40ee64b09010fa3a55d5f1e7f93d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17211673$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Banno, Shinpei</creatorcontrib><creatorcontrib>Noguchi, Rieko</creatorcontrib><creatorcontrib>Yamashita, Kazuhiro</creatorcontrib><creatorcontrib>Fukumori, Fumiyasu</creatorcontrib><creatorcontrib>Kimura, Makoto</creatorcontrib><creatorcontrib>Yamaguchi, Isamu</creatorcontrib><creatorcontrib>Fujimura, Makoto</creatorcontrib><title>Roles of putative His-to-Asp signaling modules HPT-1 and RRG-2, on viability and sensitivity to osmotic and oxidative stresses in Neurospora crassa</title><title>Current genetics</title><addtitle>Curr Genet</addtitle><description>Neurospora crassa has a putative histidine phosphotransfer protein (HPT-1) that transfers signals from 11 histidine kinases to two putative response regulators (RRG-1 and RRG-2) in its histidine-to-aspartate phosphorelay system. The hpt-1 gene was successfully disrupted in the os-2 (MAP kinase gene) mutant, but not in the wild-type strain in this study. Crossing the resultant hpt-1; os-2 mutants with the wild-type or os-1 (histidine kinase gene) mutant strains produced no progeny with hpt-1 or os-1; hpt-1 mutation, strongly suggesting that hpt-1 is essential for growth unless downstream OS-2 is inactivated. hpt-1 mutation partially recovered the osmotic sensitivity of os-2 mutants, implying the involvement of yeast Skn7-like RRG-2 in osmoregulation. However, the rrg-2 disruption did not change the osmotic sensitivity of the wild-type strain and the os-2 mutant, suggesting that rrg-2 did not participate in the osmoregulation. Both rrg-2 and os-2 single mutation slightly increased sensitivity to t-butyl hydroperoxide, and rrg-2 and hpt-1 mutations increased the os-2 mutant's sensitivity. Although OS-1 is considered as a positive regulator of OS-2 MAP kinase, our results suggested that HPT-1 negatively regulated downstream MAP kinase cascade, and that OS-2 and RRG-2 probably participate independently in the oxidative stress response in N. crassa.</description><subject>Amino Acid Motifs - genetics</subject><subject>Amino Acid Sequence</subject><subject>Amino Acid Substitution - genetics</subject><subject>Aminoimidazole Carboxamide - analogs & derivatives</subject><subject>Aminoimidazole Carboxamide - pharmacology</subject><subject>Aspartic Acid - genetics</subject><subject>Aspartic Acid - physiology</subject><subject>Butyl hydroperoxide</subject><subject>Fungal Proteins - genetics</subject><subject>Fungal Proteins - physiology</subject><subject>Fungicides, Industrial - pharmacology</subject><subject>Genetic crosses</subject><subject>Histidine</subject><subject>Histidine - genetics</subject><subject>Histidine - physiology</subject><subject>Histidine Kinase</subject><subject>Histidine phosphotransfer</subject><subject>Hydantoins - 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The hpt-1 gene was successfully disrupted in the os-2 (MAP kinase gene) mutant, but not in the wild-type strain in this study. Crossing the resultant hpt-1; os-2 mutants with the wild-type or os-1 (histidine kinase gene) mutant strains produced no progeny with hpt-1 or os-1; hpt-1 mutation, strongly suggesting that hpt-1 is essential for growth unless downstream OS-2 is inactivated. hpt-1 mutation partially recovered the osmotic sensitivity of os-2 mutants, implying the involvement of yeast Skn7-like RRG-2 in osmoregulation. However, the rrg-2 disruption did not change the osmotic sensitivity of the wild-type strain and the os-2 mutant, suggesting that rrg-2 did not participate in the osmoregulation. Both rrg-2 and os-2 single mutation slightly increased sensitivity to t-butyl hydroperoxide, and rrg-2 and hpt-1 mutations increased the os-2 mutant's sensitivity. Although OS-1 is considered as a positive regulator of OS-2 MAP kinase, our results suggested that HPT-1 negatively regulated downstream MAP kinase cascade, and that OS-2 and RRG-2 probably participate independently in the oxidative stress response in N. crassa.</abstract><cop>United States</cop><pub>Berlin/Heidelberg : Springer-Verlag</pub><pmid>17211673</pmid><doi>10.1007/s00294-006-0116-8</doi><tpages>12</tpages></addata></record> |
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| ispartof | Current genetics, 2007-03, Vol.51 (3), p.197-208 |
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| subjects | Amino Acid Motifs - genetics Amino Acid Sequence Amino Acid Substitution - genetics Aminoimidazole Carboxamide - analogs & derivatives Aminoimidazole Carboxamide - pharmacology Aspartic Acid - genetics Aspartic Acid - physiology Butyl hydroperoxide Fungal Proteins - genetics Fungal Proteins - physiology Fungicides, Industrial - pharmacology Genetic crosses Histidine Histidine - genetics Histidine - physiology Histidine Kinase Histidine phosphotransfer Hydantoins - pharmacology MAP kinase Mitogen-Activated Protein Kinases - genetics Mitogen-Activated Protein Kinases - physiology Molecular Sequence Data Mutants Mutation Neurospora crassa Neurospora crassa - drug effects Neurospora crassa - genetics Neurospora crassa - growth & development Neurospora crassa - physiology Osmoregulation Osmotic Pressure - drug effects Oxidative stress Oxidative Stress - drug effects Oxidative Stress - genetics Oxidative Stress - physiology Point Mutation Protein Kinases - genetics Response regulator Signal Transduction - drug effects Signal Transduction - genetics Signal Transduction - physiology Two-component signal transduction Yeasts |
| title | Roles of putative His-to-Asp signaling modules HPT-1 and RRG-2, on viability and sensitivity to osmotic and oxidative stresses in Neurospora crassa |
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