Effect of the Antiviral Drug Oseltamivir (Tamiflu) on the Bacterial Community Structure of a Surface Water Ecosystem Analyzed Using Fluorescence In Situ Hybridization
The antiviral drug Tamiflu has received particular attention because of its recommended use against the influenza A H5N1 and H1N1 viruses. Given its resistance to degradation and its hydrophilicity the active metabolite, Oseltamivir Carboxylate (OC), is expected to enter the aquatic ecosystem from s...
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| Veröffentlicht in: | Bulletin of environmental contamination and toxicology 2010-11, Vol.85 (5), p.443-446 |
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| creator | Barra Caracciolo, Anna Grenni, Paola Saccà, Maria Ludovica |
| description | The antiviral drug Tamiflu has received particular attention because of its recommended use against the influenza A H5N1 and H1N1 viruses. Given its resistance to degradation and its hydrophilicity the active metabolite, Oseltamivir Carboxylate (OC), is expected to enter the aquatic ecosystem from sewage treatment plants. In the present paper the bacterial community of surface water samples, treated with OC (1.5 mg L⁻¹), was characterized by Fluorescence In Situ Hybridization (FISH) in microcosm experiments. The α-, β- and γ-Proteobacteria increased in OC-treated versus non-treated water samples during the incubation period, suggesting these bacterial groups had an active role in OC degradation. |
| doi_str_mv | 10.1007/s00128-010-0114-x |
| format | Article |
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Given its resistance to degradation and its hydrophilicity the active metabolite, Oseltamivir Carboxylate (OC), is expected to enter the aquatic ecosystem from sewage treatment plants. In the present paper the bacterial community of surface water samples, treated with OC (1.5 mg L⁻¹), was characterized by Fluorescence In Situ Hybridization (FISH) in microcosm experiments. The α-, β- and γ-Proteobacteria increased in OC-treated versus non-treated water samples during the incubation period, suggesting these bacterial groups had an active role in OC degradation.</description><identifier>ISSN: 0007-4861</identifier><identifier>EISSN: 1432-0800</identifier><identifier>DOI: 10.1007/s00128-010-0114-x</identifier><identifier>PMID: 20957346</identifier><language>eng</language><publisher>New York: New York : Springer-Verlag</publisher><subject>Alphaproteobacteria - drug effects ; Alphaproteobacteria - growth & development ; Antiviral agents ; Antiviral Agents - chemistry ; Antiviral Agents - toxicity ; Antiviral drugs ; Aquatic ecosystems ; Aquatic Pollution ; Bacteria ; Bacteria - classification ; Bacteria - drug effects ; Bacteria - growth & development ; Betaproteobacteria - drug effects ; Betaproteobacteria - growth & development ; Biodegradation ; Biota ; Community structure ; drugs ; Earth and Environmental Science ; Ecotoxicology ; Environment ; Environmental Chemistry ; Environmental Health ; fish ; Fluorescence ; Fluorescence in situ hybridization ; Fresh Water - chemistry ; Fresh Water - microbiology ; Gammaproteobacteria - drug effects ; Gammaproteobacteria - growth & development ; Hybridization ; Hydrophobic and Hydrophilic Interactions ; In Situ Hybridization, Fluorescence ; Metabolites ; Oseltamivir - chemistry ; Oseltamivir - toxicity ; Pollution ; Sewage treatment ; Sewage treatment plants ; Soil Science & Conservation ; Surface water ; Tamiflu ; Treated water ; Waste Water Technology ; Wastewater treatment plants ; Water analysis ; Water Management ; Water Microbiology ; Water Pollutants, Chemical - chemistry ; Water Pollutants, Chemical - toxicity ; Water Pollution Control ; Water sampling ; Water treatment plants</subject><ispartof>Bulletin of environmental contamination and toxicology, 2010-11, Vol.85 (5), p.443-446</ispartof><rights>Springer Science+Business Media, LLC 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-52cb6d4375c46a17da3ce58f8404fcd40ad27a3f803427c065767d601e74de593</citedby><cites>FETCH-LOGICAL-c426t-52cb6d4375c46a17da3ce58f8404fcd40ad27a3f803427c065767d601e74de593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00128-010-0114-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00128-010-0114-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20957346$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barra Caracciolo, Anna</creatorcontrib><creatorcontrib>Grenni, Paola</creatorcontrib><creatorcontrib>Saccà, Maria Ludovica</creatorcontrib><title>Effect of the Antiviral Drug Oseltamivir (Tamiflu) on the Bacterial Community Structure of a Surface Water Ecosystem Analyzed Using Fluorescence In Situ Hybridization</title><title>Bulletin of environmental contamination and toxicology</title><addtitle>Bull Environ Contam Toxicol</addtitle><addtitle>Bull Environ Contam Toxicol</addtitle><description>The antiviral drug Tamiflu has received particular attention because of its recommended use against the influenza A H5N1 and H1N1 viruses. Given its resistance to degradation and its hydrophilicity the active metabolite, Oseltamivir Carboxylate (OC), is expected to enter the aquatic ecosystem from sewage treatment plants. In the present paper the bacterial community of surface water samples, treated with OC (1.5 mg L⁻¹), was characterized by Fluorescence In Situ Hybridization (FISH) in microcosm experiments. The α-, β- and γ-Proteobacteria increased in OC-treated versus non-treated water samples during the incubation period, suggesting these bacterial groups had an active role in OC degradation.</description><subject>Alphaproteobacteria - drug effects</subject><subject>Alphaproteobacteria - growth & development</subject><subject>Antiviral agents</subject><subject>Antiviral Agents - chemistry</subject><subject>Antiviral Agents - toxicity</subject><subject>Antiviral drugs</subject><subject>Aquatic ecosystems</subject><subject>Aquatic Pollution</subject><subject>Bacteria</subject><subject>Bacteria - classification</subject><subject>Bacteria - drug effects</subject><subject>Bacteria - growth & development</subject><subject>Betaproteobacteria - drug effects</subject><subject>Betaproteobacteria - growth & development</subject><subject>Biodegradation</subject><subject>Biota</subject><subject>Community structure</subject><subject>drugs</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>fish</subject><subject>Fluorescence</subject><subject>Fluorescence in situ hybridization</subject><subject>Fresh Water - chemistry</subject><subject>Fresh Water - microbiology</subject><subject>Gammaproteobacteria - drug effects</subject><subject>Gammaproteobacteria - growth & development</subject><subject>Hybridization</subject><subject>Hydrophobic and Hydrophilic Interactions</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Metabolites</subject><subject>Oseltamivir - chemistry</subject><subject>Oseltamivir - toxicity</subject><subject>Pollution</subject><subject>Sewage treatment</subject><subject>Sewage treatment plants</subject><subject>Soil Science & Conservation</subject><subject>Surface water</subject><subject>Tamiflu</subject><subject>Treated water</subject><subject>Waste Water Technology</subject><subject>Wastewater treatment plants</subject><subject>Water analysis</subject><subject>Water Management</subject><subject>Water Microbiology</subject><subject>Water Pollutants, Chemical - chemistry</subject><subject>Water Pollutants, Chemical - toxicity</subject><subject>Water Pollution Control</subject><subject>Water sampling</subject><subject>Water treatment plants</subject><issn>0007-4861</issn><issn>1432-0800</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqF0U1vFCEYB_CJ0di1-gG8KPGiHkYf3gb2WNfWNmnSw3bjkbAMrDQzQ8uL6fYD-Tllu1UTD3ogEPg9D4R_07zE8AEDiI8JABPZAoY6MGtvHzUzzChpQQI8bmZQUctkhw-aZyldVc0lIU-bAwJzLijrZs2PY-esySg4lL9ZdDRl_91HPaDPsWzQRbJD1uNuC727rAs3lPcoTPf2kzbZRl_tIoxjmXzeomWOxeQS7a6hRssSnTYWfdVVomMT0jZlO9Zr9LC9sz1aJT9t0MlQQrTJ2KnaswktfS7odLuOvvd3OvswPW-eOD0k--JhPmxWJ8eXi9P2_OLL2eLovDWMdLnlxKy7nlHBDes0Fr2mxnLpJAPmTM9A90Ro6iRQRoSBjotO9B1gK1hv-ZweNm_3fa9juCk2ZTX6-q5h0JMNJSnJOyGwxPj_EnPOO0ygyjd_yatQYv2Be4SlnM9FRXiPTAwpRevUdfSjjluFQe3CVvuwVQ1b7cJWt7Xm1UPjsh5t_7viV7oVkD1I9Wja2Pjn5n91fb0vcjoovYk-qdWSAKaA51hQoPQnw4a_IQ</recordid><startdate>20101101</startdate><enddate>20101101</enddate><creator>Barra Caracciolo, Anna</creator><creator>Grenni, Paola</creator><creator>Saccà, Maria Ludovica</creator><general>New York : Springer-Verlag</general><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T7</scope><scope>7TK</scope><scope>7TV</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>P64</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>7X8</scope><scope>7QL</scope><scope>7ST</scope><scope>7U9</scope><scope>H94</scope><scope>SOI</scope></search><sort><creationdate>20101101</creationdate><title>Effect of the Antiviral Drug Oseltamivir (Tamiflu) on the Bacterial Community Structure of a Surface Water Ecosystem Analyzed Using Fluorescence In Situ Hybridization</title><author>Barra Caracciolo, Anna ; Grenni, Paola ; Saccà, Maria Ludovica</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-52cb6d4375c46a17da3ce58f8404fcd40ad27a3f803427c065767d601e74de593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Alphaproteobacteria - 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Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environment Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Environment Abstracts</collection><jtitle>Bulletin of environmental contamination and toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barra Caracciolo, Anna</au><au>Grenni, Paola</au><au>Saccà, Maria Ludovica</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of the Antiviral Drug Oseltamivir (Tamiflu) on the Bacterial Community Structure of a Surface Water Ecosystem Analyzed Using Fluorescence In Situ Hybridization</atitle><jtitle>Bulletin of environmental contamination and toxicology</jtitle><stitle>Bull Environ Contam Toxicol</stitle><addtitle>Bull Environ Contam Toxicol</addtitle><date>2010-11-01</date><risdate>2010</risdate><volume>85</volume><issue>5</issue><spage>443</spage><epage>446</epage><pages>443-446</pages><issn>0007-4861</issn><eissn>1432-0800</eissn><abstract>The antiviral drug Tamiflu has received particular attention because of its recommended use against the influenza A H5N1 and H1N1 viruses. Given its resistance to degradation and its hydrophilicity the active metabolite, Oseltamivir Carboxylate (OC), is expected to enter the aquatic ecosystem from sewage treatment plants. In the present paper the bacterial community of surface water samples, treated with OC (1.5 mg L⁻¹), was characterized by Fluorescence In Situ Hybridization (FISH) in microcosm experiments. The α-, β- and γ-Proteobacteria increased in OC-treated versus non-treated water samples during the incubation period, suggesting these bacterial groups had an active role in OC degradation.</abstract><cop>New York</cop><pub>New York : Springer-Verlag</pub><pmid>20957346</pmid><doi>10.1007/s00128-010-0114-x</doi><tpages>4</tpages></addata></record> |
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| ispartof | Bulletin of environmental contamination and toxicology, 2010-11, Vol.85 (5), p.443-446 |
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| subjects | Alphaproteobacteria - drug effects Alphaproteobacteria - growth & development Antiviral agents Antiviral Agents - chemistry Antiviral Agents - toxicity Antiviral drugs Aquatic ecosystems Aquatic Pollution Bacteria Bacteria - classification Bacteria - drug effects Bacteria - growth & development Betaproteobacteria - drug effects Betaproteobacteria - growth & development Biodegradation Biota Community structure drugs Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health fish Fluorescence Fluorescence in situ hybridization Fresh Water - chemistry Fresh Water - microbiology Gammaproteobacteria - drug effects Gammaproteobacteria - growth & development Hybridization Hydrophobic and Hydrophilic Interactions In Situ Hybridization, Fluorescence Metabolites Oseltamivir - chemistry Oseltamivir - toxicity Pollution Sewage treatment Sewage treatment plants Soil Science & Conservation Surface water Tamiflu Treated water Waste Water Technology Wastewater treatment plants Water analysis Water Management Water Microbiology Water Pollutants, Chemical - chemistry Water Pollutants, Chemical - toxicity Water Pollution Control Water sampling Water treatment plants |
| title | Effect of the Antiviral Drug Oseltamivir (Tamiflu) on the Bacterial Community Structure of a Surface Water Ecosystem Analyzed Using Fluorescence In Situ Hybridization |
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