Triptolide Alleviates Hepatic Ischemia/Reperfusion Injury by Attenuating Oxidative Stress and Inhibiting NF-κB Activity in Mice

Background Hepatic I/R injury is unavoidable in liver transplantation and surgery. This remains a significant problem in surgical procedures. The purpose of this study was to investigate the effects of triptolide on liver ischemia/reperfusion (I/R) injury and related mechanisms in mice. Materials an...

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Veröffentlicht in:	The Journal of surgical research 2011-04, Vol.166 (2), p.e205-e213
Hauptverfasser:	Wu, Chuanxing, M.A, Wang, Ping, M.D, Rao, Jianhua, M.A, Wang, Zhaojing, M.A, Zhang, Chuanyong, M.D, Lu, Ling, M.D., Ph.D, Zhang, Feng, M.D., Ph.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Transaminase - blood Animals Aspartate Aminotransferases - blood Diterpenes - pharmacology Epoxy Compounds - pharmacology I-kappa B Proteins - metabolism Immunosuppressive Agents - pharmacology Interleukin-1beta - genetics Interleukin-6 - genetics ischemia/reperfusion Liver Diseases - drug therapy Liver Diseases - immunology Liver Diseases - metabolism liver injury Male Malondialdehyde - metabolism Mice Mice, Inbred C57BL neutrophil Neutrophils - immunology NF-kappa B - antagonists & inhibitors NF-kappa B - metabolism NF-KappaB Inhibitor alpha NF-κB Oxidative Stress - drug effects Peroxidase - metabolism Phenanthrenes - pharmacology reactive oxygen species Reperfusion Injury - drug therapy Reperfusion Injury - immunology Reperfusion Injury - metabolism RNA, Messenger - metabolism Surgery triptolide Tumor Necrosis Factor-alpha - genetics
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