Evaluation of developmental toxicant identification using gene expression profiling in embryonic stem cell differentiation cultures

The murine embryonic stem cell test (EST) is an alternative testing method designed to assess potential developmental toxicity of compounds. The implementation of transcriptomics in the EST has been shown to reduce the culture duration and improve endpoint evaluation and is expected to result in an...

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Veröffentlicht in:	Toxicological sciences 2011-01, Vol.119 (1), p.126-134
Hauptverfasser:	van Dartel, Dorien A M, Pennings, Jeroen L A, de la Fonteyne, Liset J J, Brauers, Karen J J, Claessen, Sandra, van Delft, Joost H, Kleinjans, Jos C S, Piersma, Aldert H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Testing Alternatives Animals Cell culture Cell Culture Techniques Cell Differentiation - drug effects Cell Differentiation - genetics Cell Survival - drug effects Embryonic Stem Cells - drug effects Gene Expression - drug effects Gene Expression Profiling Mice Myocytes, Cardiac - drug effects Predictive Value of Tests Teratogens - toxicity Toxicity Tests - methods Toxicogenetics
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