Impact of malignant arterial hypertension on the heart
OBJECTIVESTo assess the consequences of malignant hypertension and its evolution with antihypertensive treatment. BACKGROUNDMalignant hypertension can be considered as a model of the effects of very high blood pressure and renin–angiotensin levels on target organs. However, the consequences on the h...
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| Veröffentlicht in: | Journal of hypertension 2011-04, Vol.29 (4), p.798-802 |
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| creator | Gosse, Philippe Coulon, Paul Papaioannou, Georgios Litalien, Jean Lemetayer, Philippe |
| description | OBJECTIVESTo assess the consequences of malignant hypertension and its evolution with antihypertensive treatment.
BACKGROUNDMalignant hypertension can be considered as a model of the effects of very high blood pressure and renin–angiotensin levels on target organs. However, the consequences on the heart have been little studied.
METHODSThe consequences of malignant hypertension on left-ventricular function and its evolution with treatment were assessed with echocardiography in a prospective study between January 2004 and June 2009.
RESULTSDuring the study period, 46 patients were referred to our unit for malignant hypertension of whom 25 could be included in the echocardiographic study. These patients showed at baseline important left-ventricular hypertrophy and alteration in systolic function. Global longitudinal strain was the most sensitive tool to assess impaired systolic function and was significantly reduced in 13 patients ( |
| doi_str_mv | 10.1097/HJH.0b013e3283430b12 |
| format | Article |
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BACKGROUNDMalignant hypertension can be considered as a model of the effects of very high blood pressure and renin–angiotensin levels on target organs. However, the consequences on the heart have been little studied.
METHODSThe consequences of malignant hypertension on left-ventricular function and its evolution with treatment were assessed with echocardiography in a prospective study between January 2004 and June 2009.
RESULTSDuring the study period, 46 patients were referred to our unit for malignant hypertension of whom 25 could be included in the echocardiographic study. These patients showed at baseline important left-ventricular hypertrophy and alteration in systolic function. Global longitudinal strain was the most sensitive tool to assess impaired systolic function and was significantly reduced in 13 patients (<12.8, 52%). Short-term follow-up (1–3 months) showed a rapid improvement in systolic function together with significant hypertrophy regression. With a follow-up of 11 months on average all patients had recovered a normal global longitudinal strain with further but incomplete regression of hypertrophy.
CONCLUSIONSOur study highlights the significant impact of malignant hypertension on systolic function of the left ventricle, and the ability of this ventricle to quickly recover normal systolic function under antihypertensive treatment.</description><identifier>ISSN: 0263-6352</identifier><identifier>EISSN: 1473-5598</identifier><identifier>DOI: 10.1097/HJH.0b013e3283430b12</identifier><identifier>PMID: 21178780</identifier><identifier>CODEN: JOHYD3</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Adult ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; Female ; Heart - physiopathology ; Humans ; Hypertension - physiopathology ; Male ; Medical sciences ; Middle Aged</subject><ispartof>Journal of hypertension, 2011-04, Vol.29 (4), p.798-802</ispartof><rights>2011 Lippincott Williams & Wilkins, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3852-dfe97c43f7b81dcf9a99dd2a48b1b997cd282453f290dde47e388020eba791de3</citedby><cites>FETCH-LOGICAL-c3852-dfe97c43f7b81dcf9a99dd2a48b1b997cd282453f290dde47e388020eba791de3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24060336$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21178780$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gosse, Philippe</creatorcontrib><creatorcontrib>Coulon, Paul</creatorcontrib><creatorcontrib>Papaioannou, Georgios</creatorcontrib><creatorcontrib>Litalien, Jean</creatorcontrib><creatorcontrib>Lemetayer, Philippe</creatorcontrib><title>Impact of malignant arterial hypertension on the heart</title><title>Journal of hypertension</title><addtitle>J Hypertens</addtitle><description>OBJECTIVESTo assess the consequences of malignant hypertension and its evolution with antihypertensive treatment.
BACKGROUNDMalignant hypertension can be considered as a model of the effects of very high blood pressure and renin–angiotensin levels on target organs. However, the consequences on the heart have been little studied.
METHODSThe consequences of malignant hypertension on left-ventricular function and its evolution with treatment were assessed with echocardiography in a prospective study between January 2004 and June 2009.
RESULTSDuring the study period, 46 patients were referred to our unit for malignant hypertension of whom 25 could be included in the echocardiographic study. These patients showed at baseline important left-ventricular hypertrophy and alteration in systolic function. Global longitudinal strain was the most sensitive tool to assess impaired systolic function and was significantly reduced in 13 patients (<12.8, 52%). Short-term follow-up (1–3 months) showed a rapid improvement in systolic function together with significant hypertrophy regression. With a follow-up of 11 months on average all patients had recovered a normal global longitudinal strain with further but incomplete regression of hypertrophy.
CONCLUSIONSOur study highlights the significant impact of malignant hypertension on systolic function of the left ventricle, and the ability of this ventricle to quickly recover normal systolic function under antihypertensive treatment.</description><subject>Adult</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>Female</subject><subject>Heart - physiopathology</subject><subject>Humans</subject><subject>Hypertension - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><issn>0263-6352</issn><issn>1473-5598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAQgIMo7rr6D0R6EU9dJ0nbJEcRdVcWvOi5pM3UVtOHSZdl_72RXRU8CAMzMN88-Ag5pzCnoMT14nExhwIoR84kTzgUlB2QKU0Ej9NUyUMyBZbxOOMpm5AT798AQCrBj8mEUSqkkDAl2bIddDlGfRW12javne7GSLsRXaNtVG8HDHXnm76LQow1RjWG9ik5qrT1eLbPM_Jyf_d8u4hXTw_L25tVXHKZsthUqESZ8EoUkpqyUlopY5hOZEELFVqGSZakvGIKjMFEIJcSGGChhaIG-Yxc7fYOrv9Yox_ztvElWqs77Nc-l2kmBGQiDWSyI0vXe--wygfXtNptcwr5l7A8CMv_CgtjF_sD66JF8zP0bSgAl3tA-1LbyumubPwvl0AGnGeBkztu09tgz7_b9QZdHmzZsf7_h09mnYVu</recordid><startdate>201104</startdate><enddate>201104</enddate><creator>Gosse, Philippe</creator><creator>Coulon, Paul</creator><creator>Papaioannou, Georgios</creator><creator>Litalien, Jean</creator><creator>Lemetayer, Philippe</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201104</creationdate><title>Impact of malignant arterial hypertension on the heart</title><author>Gosse, Philippe ; Coulon, Paul ; Papaioannou, Georgios ; Litalien, Jean ; Lemetayer, Philippe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3852-dfe97c43f7b81dcf9a99dd2a48b1b997cd282453f290dde47e388020eba791de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</topic><topic>Female</topic><topic>Heart - physiopathology</topic><topic>Humans</topic><topic>Hypertension - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gosse, Philippe</creatorcontrib><creatorcontrib>Coulon, Paul</creatorcontrib><creatorcontrib>Papaioannou, Georgios</creatorcontrib><creatorcontrib>Litalien, Jean</creatorcontrib><creatorcontrib>Lemetayer, Philippe</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gosse, Philippe</au><au>Coulon, Paul</au><au>Papaioannou, Georgios</au><au>Litalien, Jean</au><au>Lemetayer, Philippe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of malignant arterial hypertension on the heart</atitle><jtitle>Journal of hypertension</jtitle><addtitle>J Hypertens</addtitle><date>2011-04</date><risdate>2011</risdate><volume>29</volume><issue>4</issue><spage>798</spage><epage>802</epage><pages>798-802</pages><issn>0263-6352</issn><eissn>1473-5598</eissn><coden>JOHYD3</coden><abstract>OBJECTIVESTo assess the consequences of malignant hypertension and its evolution with antihypertensive treatment.
BACKGROUNDMalignant hypertension can be considered as a model of the effects of very high blood pressure and renin–angiotensin levels on target organs. However, the consequences on the heart have been little studied.
METHODSThe consequences of malignant hypertension on left-ventricular function and its evolution with treatment were assessed with echocardiography in a prospective study between January 2004 and June 2009.
RESULTSDuring the study period, 46 patients were referred to our unit for malignant hypertension of whom 25 could be included in the echocardiographic study. These patients showed at baseline important left-ventricular hypertrophy and alteration in systolic function. Global longitudinal strain was the most sensitive tool to assess impaired systolic function and was significantly reduced in 13 patients (<12.8, 52%). Short-term follow-up (1–3 months) showed a rapid improvement in systolic function together with significant hypertrophy regression. With a follow-up of 11 months on average all patients had recovered a normal global longitudinal strain with further but incomplete regression of hypertrophy.
CONCLUSIONSOur study highlights the significant impact of malignant hypertension on systolic function of the left ventricle, and the ability of this ventricle to quickly recover normal systolic function under antihypertensive treatment.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>21178780</pmid><doi>10.1097/HJH.0b013e3283430b12</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Clinical manifestations. Epidemiology. Investigative techniques. Etiology Female Heart - physiopathology Humans Hypertension - physiopathology Male Medical sciences Middle Aged |
| title | Impact of malignant arterial hypertension on the heart |
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