Ret finger protein 2 enhances ionizing radiation-induced apoptosis via degradation of AKT and MDM2

Ret finger protein 2 ( RFP2), a gene frequently deleted in multiple tumor types, encodes a protein with a RING finger, B-box, and coiled-coil domain that belongs to the RBCC/TRIM protein family. Although RBCC proteins are involved in diverse cellular processes such as apoptosis, proliferation, diffe...

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Veröffentlicht in:	European journal of cell biology 2011-05, Vol.90 (5), p.420-431
Hauptverfasser:	Joo, Hae Mi, Kim, Ji Young, Jeong, Jae Boon, Seong, Ki Moon, Nam, Seon Young, Yang, Kwang Hee, Kim, Cha Soon, Kim, Hee Sun, Jeong, Meeseon, An, Sungkwan, Jin, Young Woo
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT Apoptosis Apoptosis - radiation effects DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism E3 ubiquitin ligase HEK293 Cells Humans MDM2 p53 Proteasome Endopeptidase Complex - metabolism Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-mdm2 - genetics Proto-Oncogene Proteins c-mdm2 - metabolism Radiation, Ionizing Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Ret finger protein 2 (RFP2) Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Ubiquitination
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