Cooperative Catalytic Activation of Si−H Bonds by a Polar Ru−S Bond: Regioselective Low-Temperature C−H Silylation of Indoles under Neutral Conditions by a Friedel−Crafts Mechanism

Merging cooperative Si−H bond activation and electrophilic aromatic substitution paves the way for C-3-selective indole C−H functionalization under electronic and not conventional steric control. The Si−H bond is heterolytically split by the Ru−S bond of a coordinatively unsaturated cationic rutheni...

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Veröffentlicht in:	Journal of the American Chemical Society 2011-03, Vol.133 (10), p.3312-3315
Hauptverfasser:	Klare, Hendrik F. T, Oestreich, Martin, Ito, Jun-ichi, Nishiyama, Hisao, Ohki, Yasuhiro, Tatsumi, Kazuyuki
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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