Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine

Yoshiya Kawaguchi and colleagues show that a Sox9-positive progenitor pool located in the epithelia of the biliary and pancreatic ducts of adult mice serves as a continuous source of intestinal cells, hepatocytes and pancreatic acinar cells, identifying a shared pathway underlying the cellular renew...

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Veröffentlicht in:	Nature genetics 2011-01, Vol.43 (1), p.34-41
Hauptverfasser:	Furuyama, Kenichiro, Kawaguchi, Yoshiya, Akiyama, Haruhiko, Horiguchi, Masashi, Kodama, Sota, Kuhara, Takeshi, Hosokawa, Shinichi, Elbahrawy, Ashraf, Soeda, Tsunemitsu, Koizumi, Masayuki, Masui, Toshihiko, Kawaguchi, Michiya, Takaori, Kyoichi, Doi, Ryuichiro, Nishi, Eiichiro, Kakinoki, Ryosuke, Deng, Jian Min, Behringer, Richard R, Nakamura, Takashi, Uemoto, Shinji
Format:	Artikel
Sprache:	eng
Schlagworte:	631/136/532/2118 631/136/532/489 631/208/199 Agriculture Animal Genetics and Genomics Animals Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Cell Differentiation Epithelial Cells - cytology Epithelial Cells - metabolism Fundamental and applied biological sciences. Psychology Gene expression Gene Function Genetic aspects Genetics of eukaryotes. Biological and molecular evolution Homeostasis Human Genetics Intestines Intestines - cytology Intestines - metabolism Laboratory animals Liver - cytology Liver - metabolism Mice Mice, Knockout Pancreas Pancreas - cytology Pancreas - metabolism Physiological aspects Proteins Rodents SOX9 Transcription Factor - genetics SOX9 Transcription Factor - metabolism Stem cells Stem Cells - cytology Stem Cells - metabolism
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