Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring

Paternal diet linked to glucose intolerance in daughters Childhood obesity and diabetes are closely related to these conditions in either parent, but how the father contributes is unclear. A study in rats shows that normal females mated with obese, glucose-intolerant fathers on a high-fat diet produ...

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Veröffentlicht in:	Nature (London) 2010-10, Vol.467 (7318), p.963-966
Hauptverfasser:	Ng, Sheau-Fang, Lin, Ruby C. Y., Laybutt, D. Ross, Barres, Romain, Owens, Julie A., Morris, Margaret J.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/136 631/443/319/1642/137/773 631/443/319/1642/393 Abnormalities Adenosine Triphosphate - metabolism Adiposity - drug effects Aging - genetics Animals Apoptosis - genetics Biological and medical sciences Body Weight - drug effects Care and treatment Cations - metabolism Cell Cycle - genetics Cytoskeleton - metabolism Diabetes Mellitus, Type 2 - etiology Diabetes Mellitus, Type 2 - pathology Diabetes Mellitus, Type 2 - physiopathology Diabetes. Impaired glucose tolerance Diet - adverse effects Dietary Fats - administration & dosage Dietary Fats - adverse effects DNA Methylation - drug effects Endocrine pancreas. Apud cells (diseases) Endocrinopathies Epigenesis, Genetic - drug effects Etiopathogenesis. Screening. Investigations. Target tissue resistance Fathers Female Gene Expression Profiling Gene Expression Regulation Glucose - pharmacology Glucose Intolerance - etiology Glucose Intolerance - pathology Glucose Intolerance - physiopathology Glucose Tolerance Test Health aspects Homeostasis - drug effects Humanities and Social Sciences Insulin - metabolism Insulin Secretion Insulin-Secreting Cells - metabolism Insulin-Secreting Cells - pathology letter Litter Size Male Medical sciences Metabolic diseases multidisciplinary Obesity Obesity - etiology Obesity - pathology Obesity - physiopathology Obesity in children Pancreatic beta cells Paternal Exposure - adverse effects Physiological aspects Rats Rats, Sprague-Dawley Risk factors Science Science (multidisciplinary) Signal Transduction - genetics
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