The myeloid cells of the central nervous system parenchyma
A microglial cell is both a glial cell of the central nervous system and a mononuclear phagocyte, which belongs to the haematopoietic system and is involved in inflammatory and immune responses. As such, microglia face a challenging task. The neurons of the central nervous system cannot divide and b...
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| Veröffentlicht in: | Nature (London) 2010-11, Vol.468 (7321), p.253-262 |
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| description | A microglial cell is both a glial cell of the central nervous system and a mononuclear phagocyte, which belongs to the haematopoietic system and is involved in inflammatory and immune responses. As such, microglia face a challenging task. The neurons of the central nervous system cannot divide and be replenished, and therefore need to be protected against pathogens, which is a key role of the immune system, but without collateral damage. In addition, after physical injury, neural cells need restorative support, which is provided by inflammatory responses. Excessive or chronic inflammatory responses can, however, be harmful. How microglia balance these demands, and how their behaviour can be modified to ameliorate disorders of the central nervous system, is becoming clear. |
| doi_str_mv | 10.1038/nature09615 |
| format | Article |
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As such, microglia face a challenging task. The neurons of the central nervous system cannot divide and be replenished, and therefore need to be protected against pathogens, which is a key role of the immune system, but without collateral damage. In addition, after physical injury, neural cells need restorative support, which is provided by inflammatory responses. Excessive or chronic inflammatory responses can, however, be harmful. How microglia balance these demands, and how their behaviour can be modified to ameliorate disorders of the central nervous system, is becoming clear.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>21068834</pmid><doi>10.1038/nature09615</doi><tpages>10</tpages></addata></record> |
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| subjects | 631/250/2504/133/2505 631/378/1689/364 631/378/2596/1953 692/698/1688/1366 Analysis Animals Biological and medical sciences Cell Lineage Central nervous system Central Nervous System - cytology Central Nervous System - embryology Central Nervous System - pathology Central Nervous System - physiopathology Clinical medicine Disease Embryonic development Fundamental and applied biological sciences. Psychology Humanities and Social Sciences Humans Immune response Immune system Immunology Microglia - cytology Microglia - immunology Microglia - pathology multidisciplinary Myeloid Cells - cytology Myeloid Cells - immunology Myeloid Cells - pathology Neurodegeneration Phagocytes - cytology Phagocytes - immunology Physiological aspects review-article Science Science (multidisciplinary) Stem Cells - cytology Studies T cells Vertebrates: nervous system and sense organs |
| title | The myeloid cells of the central nervous system parenchyma |
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