IL-37 is a fundamental inhibitor of innate immunity

The function of IL-37 remains elusive. Dinarello and colleagues find that IL-37 acts as a natural suppressor of innate inflammatory and immune responses. The function of interleukin 37 (IL-37; formerly IL-1 family member 7) has remained elusive. Expression of IL-37 in macrophages or epithelial cells...

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Veröffentlicht in:	Nature immunology 2010-11, Vol.11 (11), p.1014-1022
Hauptverfasser:	Dinarello, Charles A, Nold, Marcel F, Nold-Petry, Claudia A, Zepp, Jarod A, Palmer, Brent E, Bufler, Philip
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/127/1213 631/250/262 631/250/516 Animals Biomedical and Life Sciences Biomedicine Cell Line Dendritic cells Gene Knockdown Techniques Humans Immunity, Innate - immunology Immunology Infectious Diseases Interleukin-1 - genetics Interleukin-1 - immunology Interleukins Kidneys Macrophages Mice Mice, Transgenic Physiological aspects Signal Transduction Smad3 Protein - immunology
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