Radiation-induced Cancer Cell Repopulation: A Possible Mechanism Implied by Experiments Using Transplantable Mouse-derived Sarcoma Cell Line

Purpose: Treatment with any cytotoxic agent can trigger surviving cells in a tumor to divide faster than before. This phenomenon is widely recognized as “repopulation”. To better clarify the mechanism, gene expression profiling and pathological experiments were performed. Materials and Methods: A mo...

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Veröffentlicht in:	Cell Structure and Function 2011, Vol.36(1), pp.13-20
Hauptverfasser:	Nishioka, Takeshi, Yasuda, Motoaki, Takeshima, Tsuguhide, Haga, Hisashi, Miyai, Yusuke, Shibata, Ken-ichiro, Yamazaki, Rie, Shirato, Hiroki, Teduka, Masahiro, Date, Hiroyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Count Cell Division - radiation effects Cell Line, Tumor Cell Survival - radiation effects Female irradiation matrix metalloproteinase Mice Neoplasm Transplantation p16 radiotherapy repopulation Sarcoma - pathology
Online-Zugang:	Volltext
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