Critical role for the chemokine receptor CXCR6 in NK cell–mediated antigen-specific memory of haptens and viruses
NK cells confer innate immune functions. Von Andrian and colleagues show that hepatic NK cells bearing CXCR6 receptors confer antigen-specific NK cell memory that is protective against various viruses. Hepatic natural killer (NK) cells mediate antigen-specific contact hypersensitivity (CHS) in mice...
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| Veröffentlicht in: | Nature immunology 2010-12, Vol.11 (12), p.1127-1135 |
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| creator | Paust, Silke Gill, Harvinder S Wang, Bao-Zhong Flynn, Michael P Moseman, E Ashley Senman, Balimkiz Szczepanik, Marian Telenti, Amalio Askenase, Philip W Compans, Richard W von Andrian, Ulrich H |
| description | NK cells confer innate immune functions. Von Andrian and colleagues show that hepatic NK cells bearing CXCR6 receptors confer antigen-specific NK cell memory that is protective against various viruses.
Hepatic natural killer (NK) cells mediate antigen-specific contact hypersensitivity (CHS) in mice deficient in T cells and B cells. We report here that hepatic NK cells, but not splenic or naive NK cells, also developed specific memory of vaccines containing antigens from influenza, vesicular stomatitis virus (VSV) or human immunodeficiency virus type 1 (HIV-1). Adoptive transfer of virus-sensitized NK cells into naive recipient mice enhanced the survival of the mice after lethal challenge with the sensitizing virus but not after lethal challenge with a different virus. NK cell memory of haptens and viruses depended on CXCR6, a chemokine receptor on hepatic NK cells that was required for the persistence of memory NK cells but not for antigen recognition. Thus, hepatic NK cells can develop adaptive immunity to structurally diverse antigens, an activity that requires NK cell–expressed CXCR6. |
| doi_str_mv | 10.1038/ni.1953 |
| format | Article |
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Hepatic natural killer (NK) cells mediate antigen-specific contact hypersensitivity (CHS) in mice deficient in T cells and B cells. We report here that hepatic NK cells, but not splenic or naive NK cells, also developed specific memory of vaccines containing antigens from influenza, vesicular stomatitis virus (VSV) or human immunodeficiency virus type 1 (HIV-1). Adoptive transfer of virus-sensitized NK cells into naive recipient mice enhanced the survival of the mice after lethal challenge with the sensitizing virus but not after lethal challenge with a different virus. NK cell memory of haptens and viruses depended on CXCR6, a chemokine receptor on hepatic NK cells that was required for the persistence of memory NK cells but not for antigen recognition. Thus, hepatic NK cells can develop adaptive immunity to structurally diverse antigens, an activity that requires NK cell–expressed CXCR6.</description><identifier>ISSN: 1529-2908</identifier><identifier>EISSN: 1529-2916</identifier><identifier>DOI: 10.1038/ni.1953</identifier><identifier>PMID: 20972432</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>631/250/1619/382 ; 631/250/2152/1566/1571 ; 631/326/596/2553 ; Adaptive Immunity - immunology ; Adoptive Transfer ; Animals ; Antigen-antibody reactions ; Antigens ; B cells ; Biomedical and Life Sciences ; Biomedicine ; Cell Separation ; Chemokine receptors ; Chemotaxis, Leukocyte - immunology ; Contact dermatitis ; Cytotoxicity, Immunologic - immunology ; Flow Cytometry ; Haptens ; Haptens - immunology ; HIV ; Human immunodeficiency virus 1 ; Hypersensitivity ; Immunologic Memory - immunology ; Immunology ; Infectious Diseases ; Influenza ; Influenza vaccines ; Killer cells ; Killer Cells, Natural - immunology ; Killer Cells, Natural - metabolism ; Liver - cytology ; Liver - immunology ; Lymphocyte Subsets - immunology ; Lymphocyte Subsets - metabolism ; Lymphocytes ; Medical schools ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Physiological aspects ; Receptors, CXCR - immunology ; Receptors, CXCR - metabolism ; Receptors, CXCR6 ; Stomatitis ; T cells ; Vaccines ; Vesicular stomatitis virus ; Virus Diseases - immunology ; Viruses - immunology</subject><ispartof>Nature immunology, 2010-12, Vol.11 (12), p.1127-1135</ispartof><rights>Springer Nature America, Inc. 2010</rights><rights>COPYRIGHT 2010 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Dec 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c606t-8c1daf41e6509e0918c6c7797e30d8824534d8a6ad309cfcaaffce49c44181a3</citedby><cites>FETCH-LOGICAL-c606t-8c1daf41e6509e0918c6c7797e30d8824534d8a6ad309cfcaaffce49c44181a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ni.1953$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/ni.1953$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20972432$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Paust, Silke</creatorcontrib><creatorcontrib>Gill, Harvinder S</creatorcontrib><creatorcontrib>Wang, Bao-Zhong</creatorcontrib><creatorcontrib>Flynn, Michael P</creatorcontrib><creatorcontrib>Moseman, E Ashley</creatorcontrib><creatorcontrib>Senman, Balimkiz</creatorcontrib><creatorcontrib>Szczepanik, Marian</creatorcontrib><creatorcontrib>Telenti, Amalio</creatorcontrib><creatorcontrib>Askenase, Philip W</creatorcontrib><creatorcontrib>Compans, Richard W</creatorcontrib><creatorcontrib>von Andrian, Ulrich H</creatorcontrib><title>Critical role for the chemokine receptor CXCR6 in NK cell–mediated antigen-specific memory of haptens and viruses</title><title>Nature immunology</title><addtitle>Nat Immunol</addtitle><addtitle>Nat Immunol</addtitle><description>NK cells confer innate immune functions. Von Andrian and colleagues show that hepatic NK cells bearing CXCR6 receptors confer antigen-specific NK cell memory that is protective against various viruses.
Hepatic natural killer (NK) cells mediate antigen-specific contact hypersensitivity (CHS) in mice deficient in T cells and B cells. We report here that hepatic NK cells, but not splenic or naive NK cells, also developed specific memory of vaccines containing antigens from influenza, vesicular stomatitis virus (VSV) or human immunodeficiency virus type 1 (HIV-1). Adoptive transfer of virus-sensitized NK cells into naive recipient mice enhanced the survival of the mice after lethal challenge with the sensitizing virus but not after lethal challenge with a different virus. NK cell memory of haptens and viruses depended on CXCR6, a chemokine receptor on hepatic NK cells that was required for the persistence of memory NK cells but not for antigen recognition. Thus, hepatic NK cells can develop adaptive immunity to structurally diverse antigens, an activity that requires NK cell–expressed CXCR6.</description><subject>631/250/1619/382</subject><subject>631/250/2152/1566/1571</subject><subject>631/326/596/2553</subject><subject>Adaptive Immunity - immunology</subject><subject>Adoptive Transfer</subject><subject>Animals</subject><subject>Antigen-antibody reactions</subject><subject>Antigens</subject><subject>B cells</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Separation</subject><subject>Chemokine receptors</subject><subject>Chemotaxis, Leukocyte - immunology</subject><subject>Contact dermatitis</subject><subject>Cytotoxicity, Immunologic - immunology</subject><subject>Flow Cytometry</subject><subject>Haptens</subject><subject>Haptens - immunology</subject><subject>HIV</subject><subject>Human immunodeficiency virus 1</subject><subject>Hypersensitivity</subject><subject>Immunologic Memory - 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Academic</collection><jtitle>Nature immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Paust, Silke</au><au>Gill, Harvinder S</au><au>Wang, Bao-Zhong</au><au>Flynn, Michael P</au><au>Moseman, E Ashley</au><au>Senman, Balimkiz</au><au>Szczepanik, Marian</au><au>Telenti, Amalio</au><au>Askenase, Philip W</au><au>Compans, Richard W</au><au>von Andrian, Ulrich H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Critical role for the chemokine receptor CXCR6 in NK cell–mediated antigen-specific memory of haptens and viruses</atitle><jtitle>Nature immunology</jtitle><stitle>Nat Immunol</stitle><addtitle>Nat Immunol</addtitle><date>2010-12-01</date><risdate>2010</risdate><volume>11</volume><issue>12</issue><spage>1127</spage><epage>1135</epage><pages>1127-1135</pages><issn>1529-2908</issn><eissn>1529-2916</eissn><abstract>NK cells confer innate immune functions. Von Andrian and colleagues show that hepatic NK cells bearing CXCR6 receptors confer antigen-specific NK cell memory that is protective against various viruses.
Hepatic natural killer (NK) cells mediate antigen-specific contact hypersensitivity (CHS) in mice deficient in T cells and B cells. We report here that hepatic NK cells, but not splenic or naive NK cells, also developed specific memory of vaccines containing antigens from influenza, vesicular stomatitis virus (VSV) or human immunodeficiency virus type 1 (HIV-1). Adoptive transfer of virus-sensitized NK cells into naive recipient mice enhanced the survival of the mice after lethal challenge with the sensitizing virus but not after lethal challenge with a different virus. NK cell memory of haptens and viruses depended on CXCR6, a chemokine receptor on hepatic NK cells that was required for the persistence of memory NK cells but not for antigen recognition. Thus, hepatic NK cells can develop adaptive immunity to structurally diverse antigens, an activity that requires NK cell–expressed CXCR6.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>20972432</pmid><doi>10.1038/ni.1953</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 631/250/1619/382 631/250/2152/1566/1571 631/326/596/2553 Adaptive Immunity - immunology Adoptive Transfer Animals Antigen-antibody reactions Antigens B cells Biomedical and Life Sciences Biomedicine Cell Separation Chemokine receptors Chemotaxis, Leukocyte - immunology Contact dermatitis Cytotoxicity, Immunologic - immunology Flow Cytometry Haptens Haptens - immunology HIV Human immunodeficiency virus 1 Hypersensitivity Immunologic Memory - immunology Immunology Infectious Diseases Influenza Influenza vaccines Killer cells Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Liver - cytology Liver - immunology Lymphocyte Subsets - immunology Lymphocyte Subsets - metabolism Lymphocytes Medical schools Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Physiological aspects Receptors, CXCR - immunology Receptors, CXCR - metabolism Receptors, CXCR6 Stomatitis T cells Vaccines Vesicular stomatitis virus Virus Diseases - immunology Viruses - immunology |
| title | Critical role for the chemokine receptor CXCR6 in NK cell–mediated antigen-specific memory of haptens and viruses |
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