Head swivel on the ribosome facilitates translocation by means of intra-subunit tRNA hybrid sites

Turning heads on tRNA translocation on the ribosome During translation, transfer RNAs enter the ribosome and then move sequentially through three sites, known as A, P and E, as they transfer their attached amino acids onto the growing peptide chain. How the ribosome facilitates tRNA translocation be...

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Veröffentlicht in:	Nature (London) 2010-12, Vol.468 (7324), p.713-716
Hauptverfasser:	Ratje, Andreas H., Loerke, Justus, Mikolajka, Aleksandra, Brünner, Matthias, Hildebrand, Peter W., Starosta, Agata L., Dönhöfer, Alexandra, Connell, Sean R., Fucini, Paola, Mielke, Thorsten, Whitford, Paul C., Onuchic, José N., Yu, Yanan, Sanbonmatsu, Karissa Y., Hartmann, Roland K., Penczek, Pawel A., Wilson, Daniel N., Spahn, Christian M. T.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/574/1789 631/337/574/1793 631/45/535/1258/1259 631/57/2272/2273 Binding Sites Biological and medical sciences Cryoelectron Microscopy Crystallography, X-Ray Fundamental and applied biological sciences. Psychology Gram-negative bacteria Guanosine Diphosphate - chemistry Guanosine Diphosphate - metabolism Humanities and Social Sciences letter Models, Molecular Molecular and cellular biology Molecular genetics Movement multidisciplinary Peptide Elongation Factor G - chemistry Peptide Elongation Factor G - metabolism Peptides Physiological aspects Protein Biosynthesis Protein Conformation Protein Subunits - chemistry Protein Subunits - metabolism Protein synthesis Proteins Ribonucleic acid Ribosome Subunits, Small, Bacterial - chemistry Ribosome Subunits, Small, Bacterial - metabolism Ribosome Subunits, Small, Bacterial - ultrastructure Ribosomes RNA RNA, Transfer - chemistry RNA, Transfer - metabolism RNA, Transfer - ultrastructure Science Science (multidisciplinary) Structure Subpopulations Thermus thermophilus Thermus thermophilus - chemistry Transfer RNA Translation. Translation factors. Protein processing Translocation
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