Bioassay of prostate-specific antigen (PSA) using microcantilevers

Diagnosis and monitoring of complex diseases such as cancer require quantitative detection of multiple proteins. Recent work has shown that when specific biomolecular binding occurs on one surface of a microcantilever beam, intermolecular nanomechanics bend the cantilever, which can be optically det...

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Veröffentlicht in:	Nature biotechnology 2001-09, Vol.19 (9), p.856-860
Hauptverfasser:	Majumdar, Arun, Wu, Guanghua, Datar, Ram H, Hansen, Karolyn M, Thundat, Thomas, Cote, Richard J
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Antigens Bioassays Bioinformatics Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Biosensing Techniques Biotechnology Cantilevers Chemistry, Clinical - methods Deoxyribonucleic acid Disease Diverse techniques DNA DNA - metabolism Fundamental and applied biological sciences. Psychology Health. Pharmaceutical industry Humans Hybridization Industrial applications and implications. Economical aspects Lasers Life Sciences Male Medical screening Miscellaneous Models, Biological Molecular and cellular biology Plasminogen - metabolism Prostate cancer prostate-specific antigen Prostate-Specific Antigen - blood Prostatic Neoplasms - blood Prostatic Neoplasms - diagnosis Protein Binding Proteins Publishing Sensitivity and Specificity Serum Albumin - metabolism Time Factors
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