The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells

The adhesion protein E-cadherin plays a central part in the process of epithelial morphogenesis. Expression of this protein is downregulated during the acquisition of metastatic potential at late stages of epithelial tumour progression. There is evidence for a transcriptional blockage of E-cadherin...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature cell biology 2000-02, Vol.2 (2), p.84-89
Hauptverfasser:	García de Herreros, Antonio, Batlle, Eduard, Sancho, Elena, Francí, Clara, Domínguez, David, Monfar, Mercè, Baulida, Josep
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Binding Sites Biomedical and Life Sciences Cadherins - biosynthesis Cadherins - genetics Cancer Cancer cells Cancer Research Cell Biology Cells Cloning Developmental Biology DNA binding proteins DNA, Antisense DNA-Binding Proteins - metabolism Down-Regulation E-cadherin Epithelial cells Fibroblasts Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Humans Insects Life Sciences Membrane proteins Metastases Molecular Sequence Data Morphogenesis Mutation Neoplasms, Glandular and Epithelial - genetics Promoter Regions, Genetic Promoters (Genetics) Protein Binding Proteins Repressor Proteins - metabolism RNA, Messenger - biosynthesis Snail Family Transcription Factors Snail protein Stem Cells Transcription factors Transcription Factors - metabolism Tumor cell lines Tumorigenesis Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!