The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells
The adhesion protein E-cadherin plays a central part in the process of epithelial morphogenesis. Expression of this protein is downregulated during the acquisition of metastatic potential at late stages of epithelial tumour progression. There is evidence for a transcriptional blockage of E-cadherin...
Gespeichert in:
| Veröffentlicht in: | Nature cell biology 2000-02, Vol.2 (2), p.84-89 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 89 |
|---|---|
| container_issue | 2 |
| container_start_page | 84 |
| container_title | Nature cell biology |
| container_volume | 2 |
| creator | García de Herreros, Antonio Batlle, Eduard Sancho, Elena Francí, Clara Domínguez, David Monfar, Mercè Baulida, Josep |
| description | The adhesion protein E-cadherin plays a central part in the process of epithelial morphogenesis. Expression of this protein is downregulated during the acquisition of metastatic potential at late stages of epithelial tumour progression. There is evidence for a transcriptional blockage of
E-cadherin
gene expression in this process. Here we show that the transcription factor Snail, which is expressed by fibroblasts and some E-cadherin-negative epithelial tumour cell lines, binds to three E-boxes present in the human
E-cadherin
promoter and represses transcription of
E-cadherin
. Inhibition of Snail function in epithelial cancer cell lines lacking E-cadherin protein restores the expression of the
E-cadherin
gene. |
| doi_str_mv | 10.1038/35000034 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_856763797</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A183282532</galeid><sourcerecordid>A183282532</sourcerecordid><originalsourceid>FETCH-LOGICAL-c529t-631be8444569d590580ee4bd5351767298f91421b1a2f8373d59acb7a31741a23</originalsourceid><addsrcrecordid>eNqFkltrFjEQhhdR7EHBXyBBwcPF1pwPl6VULRQEW69DNjv7fSm72c9kF-q_N9ut1oqH5CLhnWfezJCpqmcEHxHM9DsmcFmMP6j2CVey5lKZh8tdiloxQ_eqg5yvMCacY_W42iNYCiG02q-6yy2gKbmYfQq7KYwRdc5PY0IX0YUehYwcSrBLkHMRxw6d1t61W0ghog1EQHB9E1wyiwS7MG2hD65H0zyMc0Ie-j4_qR51rs_w9PY8rL68P708-Viff_pwdnJ8XntBzVRLRhrQnHMhTSsMFhoD8KYVTBAlFTW6M4RT0hBHO80UK5DzjXKMKF40dli9Xn13afw6Q57sEPJSgYswztlqIZVkyqhCvvonqbA2jHHxX7C8rKk2C_jyN_Cq9B9Lu3aJC62VXCp88VeKUqaFJqRARyu0cT3YELuxfJEvu4Uh-DFCF4p-TDSjmgq2uL69l1CYCa6njZtztmcXn--zb1bWpzHnBJ3dpTC49M0SbJdxsj_GqaDPb4udmwHaX8B1fu7ezSUUN5DuuvmDGVrZ6KY5wU-z6BtMMbaas-8xkdgD</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>222385811</pqid></control><display><type>article</type><title>The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells</title><source>MEDLINE</source><source>Nature</source><source>Springer Nature - Complete Springer Journals</source><creator>García de Herreros, Antonio ; Batlle, Eduard ; Sancho, Elena ; Francí, Clara ; Domínguez, David ; Monfar, Mercè ; Baulida, Josep</creator><creatorcontrib>García de Herreros, Antonio ; Batlle, Eduard ; Sancho, Elena ; Francí, Clara ; Domínguez, David ; Monfar, Mercè ; Baulida, Josep</creatorcontrib><description>The adhesion protein E-cadherin plays a central part in the process of epithelial morphogenesis. Expression of this protein is downregulated during the acquisition of metastatic potential at late stages of epithelial tumour progression. There is evidence for a transcriptional blockage of
E-cadherin
gene expression in this process. Here we show that the transcription factor Snail, which is expressed by fibroblasts and some E-cadherin-negative epithelial tumour cell lines, binds to three E-boxes present in the human
E-cadherin
promoter and represses transcription of
E-cadherin
. Inhibition of Snail function in epithelial cancer cell lines lacking E-cadherin protein restores the expression of the
E-cadherin
gene.</description><identifier>ISSN: 1465-7392</identifier><identifier>ISSN: 1476-4679</identifier><identifier>EISSN: 1476-4679</identifier><identifier>DOI: 10.1038/35000034</identifier><identifier>PMID: 10655587</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adhesion ; Binding Sites ; Biomedical and Life Sciences ; Cadherins - biosynthesis ; Cadherins - genetics ; Cancer ; Cancer cells ; Cancer Research ; Cell Biology ; Cells ; Cloning ; Developmental Biology ; DNA binding proteins ; DNA, Antisense ; DNA-Binding Proteins - metabolism ; Down-Regulation ; E-cadherin ; Epithelial cells ; Fibroblasts ; Gene expression ; Gene Expression Regulation, Neoplastic ; Genetic aspects ; Humans ; Insects ; Life Sciences ; Membrane proteins ; Metastases ; Molecular Sequence Data ; Morphogenesis ; Mutation ; Neoplasms, Glandular and Epithelial - genetics ; Promoter Regions, Genetic ; Promoters (Genetics) ; Protein Binding ; Proteins ; Repressor Proteins - metabolism ; RNA, Messenger - biosynthesis ; Snail Family Transcription Factors ; Snail protein ; Stem Cells ; Transcription factors ; Transcription Factors - metabolism ; Tumor cell lines ; Tumorigenesis ; Tumors</subject><ispartof>Nature cell biology, 2000-02, Vol.2 (2), p.84-89</ispartof><rights>Macmillan Magazines Ltd. 2000</rights><rights>COPYRIGHT 2000 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Feb 2000</rights><rights>Macmillan Magazines Ltd. 2000.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c529t-631be8444569d590580ee4bd5351767298f91421b1a2f8373d59acb7a31741a23</citedby><cites>FETCH-LOGICAL-c529t-631be8444569d590580ee4bd5351767298f91421b1a2f8373d59acb7a31741a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/35000034$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/35000034$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27911,27912,41475,42544,51306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10655587$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>García de Herreros, Antonio</creatorcontrib><creatorcontrib>Batlle, Eduard</creatorcontrib><creatorcontrib>Sancho, Elena</creatorcontrib><creatorcontrib>Francí, Clara</creatorcontrib><creatorcontrib>Domínguez, David</creatorcontrib><creatorcontrib>Monfar, Mercè</creatorcontrib><creatorcontrib>Baulida, Josep</creatorcontrib><title>The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells</title><title>Nature cell biology</title><addtitle>Nat Cell Biol</addtitle><addtitle>Nat Cell Biol</addtitle><description>The adhesion protein E-cadherin plays a central part in the process of epithelial morphogenesis. Expression of this protein is downregulated during the acquisition of metastatic potential at late stages of epithelial tumour progression. There is evidence for a transcriptional blockage of
E-cadherin
gene expression in this process. Here we show that the transcription factor Snail, which is expressed by fibroblasts and some E-cadherin-negative epithelial tumour cell lines, binds to three E-boxes present in the human
E-cadherin
promoter and represses transcription of
E-cadherin
. Inhibition of Snail function in epithelial cancer cell lines lacking E-cadherin protein restores the expression of the
E-cadherin
gene.</description><subject>Adhesion</subject><subject>Binding Sites</subject><subject>Biomedical and Life Sciences</subject><subject>Cadherins - biosynthesis</subject><subject>Cadherins - genetics</subject><subject>Cancer</subject><subject>Cancer cells</subject><subject>Cancer Research</subject><subject>Cell Biology</subject><subject>Cells</subject><subject>Cloning</subject><subject>Developmental Biology</subject><subject>DNA binding proteins</subject><subject>DNA, Antisense</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Down-Regulation</subject><subject>E-cadherin</subject><subject>Epithelial cells</subject><subject>Fibroblasts</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Genetic aspects</subject><subject>Humans</subject><subject>Insects</subject><subject>Life Sciences</subject><subject>Membrane proteins</subject><subject>Metastases</subject><subject>Molecular Sequence Data</subject><subject>Morphogenesis</subject><subject>Mutation</subject><subject>Neoplasms, Glandular and Epithelial - genetics</subject><subject>Promoter Regions, Genetic</subject><subject>Promoters (Genetics)</subject><subject>Protein Binding</subject><subject>Proteins</subject><subject>Repressor Proteins - metabolism</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Snail Family Transcription Factors</subject><subject>Snail protein</subject><subject>Stem Cells</subject><subject>Transcription factors</subject><subject>Transcription Factors - metabolism</subject><subject>Tumor cell lines</subject><subject>Tumorigenesis</subject><subject>Tumors</subject><issn>1465-7392</issn><issn>1476-4679</issn><issn>1476-4679</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkltrFjEQhhdR7EHBXyBBwcPF1pwPl6VULRQEW69DNjv7fSm72c9kF-q_N9ut1oqH5CLhnWfezJCpqmcEHxHM9DsmcFmMP6j2CVey5lKZh8tdiloxQ_eqg5yvMCacY_W42iNYCiG02q-6yy2gKbmYfQq7KYwRdc5PY0IX0YUehYwcSrBLkHMRxw6d1t61W0ghog1EQHB9E1wyiwS7MG2hD65H0zyMc0Ie-j4_qR51rs_w9PY8rL68P708-Viff_pwdnJ8XntBzVRLRhrQnHMhTSsMFhoD8KYVTBAlFTW6M4RT0hBHO80UK5DzjXKMKF40dli9Xn13afw6Q57sEPJSgYswztlqIZVkyqhCvvonqbA2jHHxX7C8rKk2C_jyN_Cq9B9Lu3aJC62VXCp88VeKUqaFJqRARyu0cT3YELuxfJEvu4Uh-DFCF4p-TDSjmgq2uL69l1CYCa6njZtztmcXn--zb1bWpzHnBJ3dpTC49M0SbJdxsj_GqaDPb4udmwHaX8B1fu7ezSUUN5DuuvmDGVrZ6KY5wU-z6BtMMbaas-8xkdgD</recordid><startdate>20000201</startdate><enddate>20000201</enddate><creator>García de Herreros, Antonio</creator><creator>Batlle, Eduard</creator><creator>Sancho, Elena</creator><creator>Francí, Clara</creator><creator>Domínguez, David</creator><creator>Monfar, Mercè</creator><creator>Baulida, Josep</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20000201</creationdate><title>The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells</title><author>García de Herreros, Antonio ; Batlle, Eduard ; Sancho, Elena ; Francí, Clara ; Domínguez, David ; Monfar, Mercè ; Baulida, Josep</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c529t-631be8444569d590580ee4bd5351767298f91421b1a2f8373d59acb7a31741a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adhesion</topic><topic>Binding Sites</topic><topic>Biomedical and Life Sciences</topic><topic>Cadherins - biosynthesis</topic><topic>Cadherins - genetics</topic><topic>Cancer</topic><topic>Cancer cells</topic><topic>Cancer Research</topic><topic>Cell Biology</topic><topic>Cells</topic><topic>Cloning</topic><topic>Developmental Biology</topic><topic>DNA binding proteins</topic><topic>DNA, Antisense</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Down-Regulation</topic><topic>E-cadherin</topic><topic>Epithelial cells</topic><topic>Fibroblasts</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Genetic aspects</topic><topic>Humans</topic><topic>Insects</topic><topic>Life Sciences</topic><topic>Membrane proteins</topic><topic>Metastases</topic><topic>Molecular Sequence Data</topic><topic>Morphogenesis</topic><topic>Mutation</topic><topic>Neoplasms, Glandular and Epithelial - genetics</topic><topic>Promoter Regions, Genetic</topic><topic>Promoters (Genetics)</topic><topic>Protein Binding</topic><topic>Proteins</topic><topic>Repressor Proteins - metabolism</topic><topic>RNA, Messenger - biosynthesis</topic><topic>Snail Family Transcription Factors</topic><topic>Snail protein</topic><topic>Stem Cells</topic><topic>Transcription factors</topic><topic>Transcription Factors - metabolism</topic><topic>Tumor cell lines</topic><topic>Tumorigenesis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>García de Herreros, Antonio</creatorcontrib><creatorcontrib>Batlle, Eduard</creatorcontrib><creatorcontrib>Sancho, Elena</creatorcontrib><creatorcontrib>Francí, Clara</creatorcontrib><creatorcontrib>Domínguez, David</creatorcontrib><creatorcontrib>Monfar, Mercè</creatorcontrib><creatorcontrib>Baulida, Josep</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature cell biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>García de Herreros, Antonio</au><au>Batlle, Eduard</au><au>Sancho, Elena</au><au>Francí, Clara</au><au>Domínguez, David</au><au>Monfar, Mercè</au><au>Baulida, Josep</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells</atitle><jtitle>Nature cell biology</jtitle><stitle>Nat Cell Biol</stitle><addtitle>Nat Cell Biol</addtitle><date>2000-02-01</date><risdate>2000</risdate><volume>2</volume><issue>2</issue><spage>84</spage><epage>89</epage><pages>84-89</pages><issn>1465-7392</issn><issn>1476-4679</issn><eissn>1476-4679</eissn><abstract>The adhesion protein E-cadherin plays a central part in the process of epithelial morphogenesis. Expression of this protein is downregulated during the acquisition of metastatic potential at late stages of epithelial tumour progression. There is evidence for a transcriptional blockage of
E-cadherin
gene expression in this process. Here we show that the transcription factor Snail, which is expressed by fibroblasts and some E-cadherin-negative epithelial tumour cell lines, binds to three E-boxes present in the human
E-cadherin
promoter and represses transcription of
E-cadherin
. Inhibition of Snail function in epithelial cancer cell lines lacking E-cadherin protein restores the expression of the
E-cadherin
gene.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>10655587</pmid><doi>10.1038/35000034</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1465-7392 |
| ispartof | Nature cell biology, 2000-02, Vol.2 (2), p.84-89 |
| issn | 1465-7392 1476-4679 1476-4679 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_856763797 |
| source | MEDLINE; Nature; Springer Nature - Complete Springer Journals |
| subjects | Adhesion Binding Sites Biomedical and Life Sciences Cadherins - biosynthesis Cadherins - genetics Cancer Cancer cells Cancer Research Cell Biology Cells Cloning Developmental Biology DNA binding proteins DNA, Antisense DNA-Binding Proteins - metabolism Down-Regulation E-cadherin Epithelial cells Fibroblasts Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Humans Insects Life Sciences Membrane proteins Metastases Molecular Sequence Data Morphogenesis Mutation Neoplasms, Glandular and Epithelial - genetics Promoter Regions, Genetic Promoters (Genetics) Protein Binding Proteins Repressor Proteins - metabolism RNA, Messenger - biosynthesis Snail Family Transcription Factors Snail protein Stem Cells Transcription factors Transcription Factors - metabolism Tumor cell lines Tumorigenesis Tumors |
| title | The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T19%3A10%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20transcription%20factor%20Snail%20is%20a%20repressor%20of%20E-cadherin%20gene%20expression%20in%20epithelial%20tumour%20cells&rft.jtitle=Nature%20cell%20biology&rft.au=Garc%C3%ADa%20de%20Herreros,%20Antonio&rft.date=2000-02-01&rft.volume=2&rft.issue=2&rft.spage=84&rft.epage=89&rft.pages=84-89&rft.issn=1465-7392&rft.eissn=1476-4679&rft_id=info:doi/10.1038/35000034&rft_dat=%3Cgale_proqu%3EA183282532%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=222385811&rft_id=info:pmid/10655587&rft_galeid=A183282532&rfr_iscdi=true |