DARPP-32 and regulation of the ethanol sensitivity of NMDA receptors in the nucleus accumbens

The medium spiny neurons of the nucleus accumbens receive both an excitatory glutamatergic input from forebrain and a dopaminergic input from the ventral tegmental area. This integration point may constitute a locus whereby the N -methyl- D -aspartate (NMDA)-subtype of glutamate receptors promotes d...

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Veröffentlicht in:	Nature neuroscience 2002-07, Vol.5 (7), p.641-648
Hauptverfasser:	Maldve, R. E., Zhang, T. A., Ferrani-Kile, K., Schreiber, S. S., Lippmann, M. J., Snyder, G. L., Fienberg, A. A., Leslie, S. W., Gonzales, R. A., Morrisett, R. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine - pharmacology Animal Genetics and Genomics Animals Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Cell nuclei Cyclic AMP - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism Dopamine - metabolism Dopamine Agonists - pharmacology Dopamine and cAMP-Regulated Phosphoprotein 32 Ethanol - pharmacology In Vitro Techniques Mice Mice, Knockout Nerve Tissue Proteins Neurobiology Neuronal Plasticity - drug effects Neuronal Plasticity - physiology Neurosciences Neurotransmitter receptors Nucleus Accumbens - cytology Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism Phosphoproteins - deficiency Phosphoproteins - genetics Phosphoproteins - metabolism Phosphorylation - drug effects Physiological aspects Rats Receptors, Dopamine D1 - metabolism Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - drug effects Receptors, N-Methyl-D-Aspartate - metabolism Ventral Tegmental Area - physiology
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