Bone marrow cells regenerate infarcted myocardium

Myocardial infarction leads to loss of tissue and impairment of cardiac performance. The remaining myocytes are unable to reconstitute the necrotic tissue, and the post-infarcted heart deteriorates with time 1 . Injury to a target organ is sensed by distant stem cells, which migrate to the site of d...

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Veröffentlicht in:	Nature (London) 2001-04, Vol.410 (6829), p.701-705
Hauptverfasser:	Orlic, Donald, Kajstura, Jan, Chimenti, Stefano, Jakoniuk, Igor, Anderson, Stacie M., Li, Baosheng, Pickel, James, McKay, Ronald, Nadal-Ginard, Bernardo, Bodine, David M., Leri, Annarosa, Anversa, Piero
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Bone marrow Bone Marrow Transplantation Cardiology. Vascular system Cell Differentiation Cells Connexin 43 - metabolism Coronary heart disease DNA-Binding Proteins - metabolism Female Green Fluorescent Proteins Heart Humanities and Social Sciences Ki-67 Antigen - metabolism letter Luminescent Proteins - metabolism Male Medical sciences MEF2 Transcription Factors Mice Mice, Inbred C57BL Mice, Transgenic multidisciplinary Myocardial infarction Myocardial Infarction - therapy Myocardium - cytology Myocardium - pathology Myogenic Regulatory Factors Proto-Oncogene Proteins c-kit - metabolism Science Stem cells Tissues Transcription Factors - metabolism Transplants & implants
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