Bone marrow cells regenerate infarcted myocardium
Myocardial infarction leads to loss of tissue and impairment of cardiac performance. The remaining myocytes are unable to reconstitute the necrotic tissue, and the post-infarcted heart deteriorates with time 1 . Injury to a target organ is sensed by distant stem cells, which migrate to the site of d...
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| Veröffentlicht in: | Nature (London) 2001-04, Vol.410 (6829), p.701-705 |
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| creator | Orlic, Donald Kajstura, Jan Chimenti, Stefano Jakoniuk, Igor Anderson, Stacie M. Li, Baosheng Pickel, James McKay, Ronald Nadal-Ginard, Bernardo Bodine, David M. Leri, Annarosa Anversa, Piero |
| description | Myocardial infarction leads to loss of tissue and impairment of cardiac performance. The remaining myocytes are unable to reconstitute the necrotic tissue, and the post-infarcted heart deteriorates with time
1
. Injury to a target organ is sensed by distant stem cells, which migrate to the site of damage and undergo alternate stem cell differentiation
2
,
3
,
4
,
5
; these events promote structural and functional repair
6
,
7
,
8
. This high degree of stem cell plasticity prompted us to test whether dead myocardium could be restored by transplanting bone marrow cells in infarcted mice. We sorted lineage-negative (Lin
-
) bone marrow cells from transgenic mice expressing enhanced green fluorescent protein
9
by fluorescence-activated cell sorting on the basis of c-
kit
expression
10
. Shortly after coronary ligation, Lin
-
c-
kit
POS
cells were injected in the contracting wall bordering the infarct. Here we report that newly formed myocardium occupied 68% of the infarcted portion of the ventricle 9?days after transplanting the bone marrow cells. The developing tissue comprised proliferating myocytes and vascular structures. Our studies indicate that locally delivered bone marrow cells can generate
de novo
myocardium, ameliorating the outcome of coronary artery disease. |
| doi_str_mv | 10.1038/35070587 |
| format | Article |
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1
. Injury to a target organ is sensed by distant stem cells, which migrate to the site of damage and undergo alternate stem cell differentiation
2
,
3
,
4
,
5
; these events promote structural and functional repair
6
,
7
,
8
. This high degree of stem cell plasticity prompted us to test whether dead myocardium could be restored by transplanting bone marrow cells in infarcted mice. We sorted lineage-negative (Lin
-
) bone marrow cells from transgenic mice expressing enhanced green fluorescent protein
9
by fluorescence-activated cell sorting on the basis of c-
kit
expression
10
. Shortly after coronary ligation, Lin
-
c-
kit
POS
cells were injected in the contracting wall bordering the infarct. Here we report that newly formed myocardium occupied 68% of the infarcted portion of the ventricle 9?days after transplanting the bone marrow cells. The developing tissue comprised proliferating myocytes and vascular structures. Our studies indicate that locally delivered bone marrow cells can generate
de novo
myocardium, ameliorating the outcome of coronary artery disease.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/35070587</identifier><identifier>PMID: 11287958</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Biological and medical sciences ; Bone marrow ; Bone Marrow Transplantation ; Cardiology. Vascular system ; Cell Differentiation ; Cells ; Connexin 43 - metabolism ; Coronary heart disease ; DNA-Binding Proteins - metabolism ; Female ; Green Fluorescent Proteins ; Heart ; Humanities and Social Sciences ; Ki-67 Antigen - metabolism ; letter ; Luminescent Proteins - metabolism ; Male ; Medical sciences ; MEF2 Transcription Factors ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; multidisciplinary ; Myocardial infarction ; Myocardial Infarction - therapy ; Myocardium - cytology ; Myocardium - pathology ; Myogenic Regulatory Factors ; Proto-Oncogene Proteins c-kit - metabolism ; Science ; Stem cells ; Tissues ; Transcription Factors - metabolism ; Transplants & implants</subject><ispartof>Nature (London), 2001-04, Vol.410 (6829), p.701-705</ispartof><rights>Macmillan Magazines Ltd. 2001</rights><rights>2001 INIST-CNRS</rights><rights>COPYRIGHT 2001 Nature Publishing Group</rights><rights>Copyright Macmillan Journals Ltd. Apr 5, 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c643t-7b8b0e28e61f8bc3651376483e86fad5b47a305b178dbbdce793efa9e3ade0b13</citedby><cites>FETCH-LOGICAL-c643t-7b8b0e28e61f8bc3651376483e86fad5b47a305b178dbbdce793efa9e3ade0b13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/35070587$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/35070587$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=920902$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11287958$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Orlic, Donald</creatorcontrib><creatorcontrib>Kajstura, Jan</creatorcontrib><creatorcontrib>Chimenti, Stefano</creatorcontrib><creatorcontrib>Jakoniuk, Igor</creatorcontrib><creatorcontrib>Anderson, Stacie M.</creatorcontrib><creatorcontrib>Li, Baosheng</creatorcontrib><creatorcontrib>Pickel, James</creatorcontrib><creatorcontrib>McKay, Ronald</creatorcontrib><creatorcontrib>Nadal-Ginard, Bernardo</creatorcontrib><creatorcontrib>Bodine, David M.</creatorcontrib><creatorcontrib>Leri, Annarosa</creatorcontrib><creatorcontrib>Anversa, Piero</creatorcontrib><title>Bone marrow cells regenerate infarcted myocardium</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>Myocardial infarction leads to loss of tissue and impairment of cardiac performance. The remaining myocytes are unable to reconstitute the necrotic tissue, and the post-infarcted heart deteriorates with time
1
. Injury to a target organ is sensed by distant stem cells, which migrate to the site of damage and undergo alternate stem cell differentiation
2
,
3
,
4
,
5
; these events promote structural and functional repair
6
,
7
,
8
. This high degree of stem cell plasticity prompted us to test whether dead myocardium could be restored by transplanting bone marrow cells in infarcted mice. We sorted lineage-negative (Lin
-
) bone marrow cells from transgenic mice expressing enhanced green fluorescent protein
9
by fluorescence-activated cell sorting on the basis of c-
kit
expression
10
. Shortly after coronary ligation, Lin
-
c-
kit
POS
cells were injected in the contracting wall bordering the infarct. Here we report that newly formed myocardium occupied 68% of the infarcted portion of the ventricle 9?days after transplanting the bone marrow cells. The developing tissue comprised proliferating myocytes and vascular structures. Our studies indicate that locally delivered bone marrow cells can generate
de novo
myocardium, ameliorating the outcome of coronary artery disease.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bone marrow</subject><subject>Bone Marrow Transplantation</subject><subject>Cardiology. Vascular system</subject><subject>Cell Differentiation</subject><subject>Cells</subject><subject>Connexin 43 - metabolism</subject><subject>Coronary heart disease</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Female</subject><subject>Green Fluorescent Proteins</subject><subject>Heart</subject><subject>Humanities and Social Sciences</subject><subject>Ki-67 Antigen - metabolism</subject><subject>letter</subject><subject>Luminescent Proteins - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>MEF2 Transcription Factors</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Transgenic</subject><subject>multidisciplinary</subject><subject>Myocardial infarction</subject><subject>Myocardial Infarction - therapy</subject><subject>Myocardium - cytology</subject><subject>Myocardium - pathology</subject><subject>Myogenic Regulatory Factors</subject><subject>Proto-Oncogene Proteins c-kit - metabolism</subject><subject>Science</subject><subject>Stem cells</subject><subject>Tissues</subject><subject>Transcription Factors - metabolism</subject><subject>Transplants & implants</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqF0ltrFDEUB_Agil2r4CeQxYIXZOrJ5HbmcV28FIqCVnwMmcyZZcpctskM2m9vll1dV6uSh0Dyy0ny5zD2kMMpB4EvhQIDCs0tNuPS6ExqNLfZDCDHDFDoI3YvxksAUNzIu-yI8xxNoXDG-Kuhp3nnQhi-zj21bZwHWlFPwY00b_raBT9SNe-uB-9C1UzdfXandm2kB7v5mH1-8_pi-S47__D2bLk4z7yWYsxMiSVQjqR5jaUXWnFhtERBqGtXqVIaJ0CV3GBVlpUnUwiqXUHCVQQlF8fs6bbuOgxXE8XRdk3cvND1NEzRotJG56h1kk_-KY0BoVI6_y1ppICiyDFP8vFv8nKYQp_-a3OQEo2SmxdmW7RyLdmU1TAG57fhtSnWuknLC44IYITm-6IH3q-bK_srOr0BpVFR1_gbqz4_OJDMSN_GlZtitGefPh7aF3-3i4svy_eH-tlW-zDEGKi269CkVrm2HOym7-yPvkv00S6vqeyo2sNdoyVwsgMuetfWwfW-iT9dkUMB-f4vMW30Kwr72P-48ju7AOVZ</recordid><startdate>20010405</startdate><enddate>20010405</enddate><creator>Orlic, Donald</creator><creator>Kajstura, Jan</creator><creator>Chimenti, Stefano</creator><creator>Jakoniuk, Igor</creator><creator>Anderson, Stacie M.</creator><creator>Li, Baosheng</creator><creator>Pickel, James</creator><creator>McKay, Ronald</creator><creator>Nadal-Ginard, Bernardo</creator><creator>Bodine, David M.</creator><creator>Leri, Annarosa</creator><creator>Anversa, Piero</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ATWCN</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T5</scope><scope>7TG</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>S0X</scope><scope>SOI</scope><scope>7SC</scope><scope>7SP</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>F28</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>7X8</scope><scope>7QH</scope><scope>7UA</scope></search><sort><creationdate>20010405</creationdate><title>Bone marrow cells regenerate infarcted myocardium</title><author>Orlic, Donald ; Kajstura, Jan ; Chimenti, Stefano ; Jakoniuk, Igor ; Anderson, Stacie M. ; Li, Baosheng ; Pickel, James ; McKay, Ronald ; Nadal-Ginard, Bernardo ; Bodine, David M. ; Leri, Annarosa ; Anversa, Piero</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c643t-7b8b0e28e61f8bc3651376483e86fad5b47a305b178dbbdce793efa9e3ade0b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bone marrow</topic><topic>Bone Marrow Transplantation</topic><topic>Cardiology. Vascular system</topic><topic>Cell Differentiation</topic><topic>Cells</topic><topic>Connexin 43 - metabolism</topic><topic>Coronary heart disease</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Female</topic><topic>Green Fluorescent Proteins</topic><topic>Heart</topic><topic>Humanities and Social Sciences</topic><topic>Ki-67 Antigen - metabolism</topic><topic>letter</topic><topic>Luminescent Proteins - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>MEF2 Transcription Factors</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Transgenic</topic><topic>multidisciplinary</topic><topic>Myocardial infarction</topic><topic>Myocardial Infarction - therapy</topic><topic>Myocardium - cytology</topic><topic>Myocardium - pathology</topic><topic>Myogenic Regulatory Factors</topic><topic>Proto-Oncogene Proteins c-kit - metabolism</topic><topic>Science</topic><topic>Stem cells</topic><topic>Tissues</topic><topic>Transcription Factors - metabolism</topic><topic>Transplants & implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Orlic, Donald</creatorcontrib><creatorcontrib>Kajstura, Jan</creatorcontrib><creatorcontrib>Chimenti, Stefano</creatorcontrib><creatorcontrib>Jakoniuk, Igor</creatorcontrib><creatorcontrib>Anderson, Stacie M.</creatorcontrib><creatorcontrib>Li, Baosheng</creatorcontrib><creatorcontrib>Pickel, James</creatorcontrib><creatorcontrib>McKay, Ronald</creatorcontrib><creatorcontrib>Nadal-Ginard, Bernardo</creatorcontrib><creatorcontrib>Bodine, David M.</creatorcontrib><creatorcontrib>Leri, Annarosa</creatorcontrib><creatorcontrib>Anversa, Piero</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Middle School</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>ProQuest Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health Medical collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Database (1962 - 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Academic</collection><collection>Aqualine</collection><collection>Water Resources Abstracts</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Orlic, Donald</au><au>Kajstura, Jan</au><au>Chimenti, Stefano</au><au>Jakoniuk, Igor</au><au>Anderson, Stacie M.</au><au>Li, Baosheng</au><au>Pickel, James</au><au>McKay, Ronald</au><au>Nadal-Ginard, Bernardo</au><au>Bodine, David M.</au><au>Leri, Annarosa</au><au>Anversa, Piero</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bone marrow cells regenerate infarcted myocardium</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>2001-04-05</date><risdate>2001</risdate><volume>410</volume><issue>6829</issue><spage>701</spage><epage>705</epage><pages>701-705</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><coden>NATUAS</coden><abstract>Myocardial infarction leads to loss of tissue and impairment of cardiac performance. The remaining myocytes are unable to reconstitute the necrotic tissue, and the post-infarcted heart deteriorates with time
1
. Injury to a target organ is sensed by distant stem cells, which migrate to the site of damage and undergo alternate stem cell differentiation
2
,
3
,
4
,
5
; these events promote structural and functional repair
6
,
7
,
8
. This high degree of stem cell plasticity prompted us to test whether dead myocardium could be restored by transplanting bone marrow cells in infarcted mice. We sorted lineage-negative (Lin
-
) bone marrow cells from transgenic mice expressing enhanced green fluorescent protein
9
by fluorescence-activated cell sorting on the basis of c-
kit
expression
10
. Shortly after coronary ligation, Lin
-
c-
kit
POS
cells were injected in the contracting wall bordering the infarct. Here we report that newly formed myocardium occupied 68% of the infarcted portion of the ventricle 9?days after transplanting the bone marrow cells. The developing tissue comprised proliferating myocytes and vascular structures. Our studies indicate that locally delivered bone marrow cells can generate
de novo
myocardium, ameliorating the outcome of coronary artery disease.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>11287958</pmid><doi>10.1038/35070587</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 2001-04, Vol.410 (6829), p.701-705 |
| issn | 0028-0836 1476-4687 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_856762866 |
| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature |
| subjects | Animals Biological and medical sciences Bone marrow Bone Marrow Transplantation Cardiology. Vascular system Cell Differentiation Cells Connexin 43 - metabolism Coronary heart disease DNA-Binding Proteins - metabolism Female Green Fluorescent Proteins Heart Humanities and Social Sciences Ki-67 Antigen - metabolism letter Luminescent Proteins - metabolism Male Medical sciences MEF2 Transcription Factors Mice Mice, Inbred C57BL Mice, Transgenic multidisciplinary Myocardial infarction Myocardial Infarction - therapy Myocardium - cytology Myocardium - pathology Myogenic Regulatory Factors Proto-Oncogene Proteins c-kit - metabolism Science Stem cells Tissues Transcription Factors - metabolism Transplants & implants |
| title | Bone marrow cells regenerate infarcted myocardium |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-18T16%3A41%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Bone%20marrow%20cells%20regenerate%20infarcted%20myocardium&rft.jtitle=Nature%20(London)&rft.au=Orlic,%20Donald&rft.date=2001-04-05&rft.volume=410&rft.issue=6829&rft.spage=701&rft.epage=705&rft.pages=701-705&rft.issn=0028-0836&rft.eissn=1476-4687&rft.coden=NATUAS&rft_id=info:doi/10.1038/35070587&rft_dat=%3Cgale_proqu%3EA188007361%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=204487541&rft_id=info:pmid/11287958&rft_galeid=A188007361&rfr_iscdi=true |