CD8+ T cells negatively regulate IL-4-dependent, IgG1-dominant posttransplant alloantibody production

We have previously reported that CD8(+) T cells significantly influence Ab production based on the observation that posttransplant alloantibody levels in CD8-deficient murine hepatocyte transplant recipients are markedly enhanced. However, the precise mechanisms contributing to enhanced alloantibody...

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Veröffentlicht in:	The Journal of immunology (1950) 2010-12, Vol.185 (12), p.7285-7292
Hauptverfasser:	Zimmerer, Jason M, Pham, Thomas A, Sanders, Virginia M, Bumgardner, Ginny L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer - methods Animals Antibody Formation - genetics Antibody Formation - immunology CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Graft Rejection - genetics Graft Rejection - immunology Hepatocytes - immunology Hepatocytes - transplantation Immunoglobulin G - genetics Immunoglobulin G - immunology Interferon-gamma - genetics Interferon-gamma - immunology Interleukin-4 - genetics Interleukin-4 - immunology Isoantibodies - genetics Isoantibodies - immunology Mice Mice, Knockout Transplantation, Homologous Up-Regulation - genetics Up-Regulation - immunology
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