Inhibition of p300-HAT results in a reduced histone acetylation and down-regulation of gene expression in cardiac myocytes

Histone acetylation plays an important role in cardiogenesis, but the underlying mechanism is unclear. In this study, we investigated the relationship between histone hypo-acetylation and the expression of cardiac-specific genes to explore the underlying mechanisms. Cardiac-specific genes that physi...

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Veröffentlicht in:	Life sciences (1973) 2010-12, Vol.87 (23), p.707-714
Hauptverfasser:	Sun, Huichao, Yang, Xuefang, Zhu, Jing, Lv, Tiewei, Chen, Yuan, Chen, Guozhen, Zhong, Lilin, Li, Yasha, Huang, Xupei, Huang, Guoying, Tian, Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation - drug effects Animals Animals, Newborn Blotting, Western Cardiac myocytes Chromatin Immunoprecipitation Curcumin Curcumin - pharmacology Dose-Response Relationship, Drug Down-Regulation - drug effects Enzyme Inhibitors - pharmacology Enzyme-Linked Immunosorbent Assay Epigenesis, Genetic Epigenetics Histone acetylation Histones - drug effects Histones - metabolism Mice Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism p300 p300-CBP Transcription Factors - antagonists & inhibitors Promoter Regions, Genetic Reverse Transcriptase Polymerase Chain Reaction
Online-Zugang:	Volltext
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