Gene transfer of CuZn superoxide dismutase enhances the synthesis of vascular endothelial growth factor
Nitric oxide (NO) and reactive oxygen species (ROS) are emerging as important regulators of angiogenesis. NO enhances VEGF synthesis in several cell types and is required for execution of VEGF angiogenic effect in endothelial cells. Similarly, hydrogen peroxide induces VEGF synthesis and recent stud...
Gespeichert in:
| Veröffentlicht in: | Molecular and cellular biochemistry 2004-09, Vol.264 (1-2), p.169-181 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 181 |
|---|---|
| container_issue | 1-2 |
| container_start_page | 169 |
| container_title | Molecular and cellular biochemistry |
| container_volume | 264 |
| creator | Grzenkowicz-Wydra, Jolanta Cisowski, Jarosław Nakonieczna, Joanna Zarebski, Adrian Udilova, Natalia Nohl, Hans Józkowicz, Alicja Podhajska, Anna Dulak, Józef |
| description | Nitric oxide (NO) and reactive oxygen species (ROS) are emerging as important regulators of angiogenesis. NO enhances VEGF synthesis in several cell types and is required for execution of VEGF angiogenic effect in endothelial cells. Similarly, hydrogen peroxide induces VEGF synthesis and recent studies indicate the involvement of ROS in signaling downstream of VEGF stimulation. VEGF synthesis can not only be enhanced by gene transfer of VEGF but also by overexpression of NO synthase genes. Here, we examined the possibility of augmentation of VEGF production by gene transfer of copper/zinc superoxide dismutase (CuZnSOD, SOD1). Overexpression of human SOD1 in mouse NIH 3T3 fibroblasts increased SOD activity, enhanced intracellular generation of H2O2 and significantly stimulated VEGF production as determined by increase in VEGF promoter activity, VEGF mRNA expression and VEGF protein synthesis. The stimulatory effect on VEGF synthesis induced by SOD1 gene transfer was reverted by overexpression of human catalase. The effect of H2O2 produced by engineered cells is mediated by activation of hypoxia-inducible factor response element (HRE) as well as Sp1 recognition site of VEGF promoter. This data suggest the feasibility of stimulation of angiogenesis by overexpression of SOD1. |
| doi_str_mv | 10.1023/B:MCBI.0000044386.45054.70 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_856761572</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>856761572</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-af57e3032a0dfa481ed8c06b0dbe5867d948cc039770c61f0755a35eb65d76d23</originalsourceid><addsrcrecordid>eNqFkU1r3DAQhkVpabZp_0IRObQnb0fWx8i5dZc2CSTk0l56EVppnHXw2lvJTpt_X7tZCOSQCMHA8IxeRg9jJwKWAkr5ZXV6tV5dLGE-SklrlkqDVkuEV2whNMpCVaJ6zRYgAQorEI_Yu5xvAcR0xVt2JLRWCpRZsJsz6ogPyXe5psT7mq_HXx3P455S_7eJxGOTd-PgM3Hqtr4LlPmwJZ7vu6nkJs8zdz6HsfVpQmI_tdvGt_wm9X-GLa99GPr0nr2pfZvpw6Ees5_fv_1YnxeX12cX66-XRVCgh8LXGkmCLD3E2isrKNoAZgNxQ9oajJWyIYCsECEYUQNq7aWmjdERTSzlMfv88O4-9b9HyoPbNTlQ2_qO-jE7qw2a6Y9m8tOzpEHAElG9CJZCVKXVMIEnT8DbfkzdtK5DbUqlUNsJOn2AQupzTlS7fWp2Pt07AW7W61Zu1use9br_eh3OCR8PCeNmR_Fx9OBT_gO7raF2</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>756244758</pqid></control><display><type>article</type><title>Gene transfer of CuZn superoxide dismutase enhances the synthesis of vascular endothelial growth factor</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Grzenkowicz-Wydra, Jolanta ; Cisowski, Jarosław ; Nakonieczna, Joanna ; Zarebski, Adrian ; Udilova, Natalia ; Nohl, Hans ; Józkowicz, Alicja ; Podhajska, Anna ; Dulak, Józef</creator><creatorcontrib>Grzenkowicz-Wydra, Jolanta ; Cisowski, Jarosław ; Nakonieczna, Joanna ; Zarebski, Adrian ; Udilova, Natalia ; Nohl, Hans ; Józkowicz, Alicja ; Podhajska, Anna ; Dulak, Józef</creatorcontrib><description>Nitric oxide (NO) and reactive oxygen species (ROS) are emerging as important regulators of angiogenesis. NO enhances VEGF synthesis in several cell types and is required for execution of VEGF angiogenic effect in endothelial cells. Similarly, hydrogen peroxide induces VEGF synthesis and recent studies indicate the involvement of ROS in signaling downstream of VEGF stimulation. VEGF synthesis can not only be enhanced by gene transfer of VEGF but also by overexpression of NO synthase genes. Here, we examined the possibility of augmentation of VEGF production by gene transfer of copper/zinc superoxide dismutase (CuZnSOD, SOD1). Overexpression of human SOD1 in mouse NIH 3T3 fibroblasts increased SOD activity, enhanced intracellular generation of H2O2 and significantly stimulated VEGF production as determined by increase in VEGF promoter activity, VEGF mRNA expression and VEGF protein synthesis. The stimulatory effect on VEGF synthesis induced by SOD1 gene transfer was reverted by overexpression of human catalase. The effect of H2O2 produced by engineered cells is mediated by activation of hypoxia-inducible factor response element (HRE) as well as Sp1 recognition site of VEGF promoter. This data suggest the feasibility of stimulation of angiogenesis by overexpression of SOD1.</description><identifier>ISSN: 0300-8177</identifier><identifier>EISSN: 1573-4919</identifier><identifier>DOI: 10.1023/B:MCBI.0000044386.45054.70</identifier><identifier>PMID: 15544046</identifier><language>eng</language><publisher>Netherlands: Springer Nature B.V</publisher><subject>Angiogenesis ; Animals ; beta-Galactosidase - metabolism ; Blotting, Northern ; Blotting, Western ; Catalase - metabolism ; Enzyme-Linked Immunosorbent Assay ; Gene Transfer Techniques ; Genes ; Genetic Therapy - methods ; Genetic Vectors ; Humans ; Hydrogen peroxide ; Hydrogen Peroxide - pharmacology ; Hypoxia ; Mice ; Neovascularization, Physiologic ; NIH 3T3 Cells ; Nitric oxide ; Nitric Oxide - metabolism ; Plasmids - metabolism ; Promoter Regions, Genetic ; Protein synthesis ; Reactive Oxygen Species - metabolism ; Response Elements ; Reverse Transcriptase Polymerase Chain Reaction ; Rodents ; Signal Transduction ; Sp1 Transcription Factor - metabolism ; Superoxide Dismutase - genetics ; Superoxides - metabolism ; Transfection ; Vascular endothelial growth factor ; Vascular Endothelial Growth Factor A - biosynthesis ; Vascular Endothelial Growth Factor A - metabolism</subject><ispartof>Molecular and cellular biochemistry, 2004-09, Vol.264 (1-2), p.169-181</ispartof><rights>Kluwer Academic Publishers 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-af57e3032a0dfa481ed8c06b0dbe5867d948cc039770c61f0755a35eb65d76d23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15544046$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Grzenkowicz-Wydra, Jolanta</creatorcontrib><creatorcontrib>Cisowski, Jarosław</creatorcontrib><creatorcontrib>Nakonieczna, Joanna</creatorcontrib><creatorcontrib>Zarebski, Adrian</creatorcontrib><creatorcontrib>Udilova, Natalia</creatorcontrib><creatorcontrib>Nohl, Hans</creatorcontrib><creatorcontrib>Józkowicz, Alicja</creatorcontrib><creatorcontrib>Podhajska, Anna</creatorcontrib><creatorcontrib>Dulak, Józef</creatorcontrib><title>Gene transfer of CuZn superoxide dismutase enhances the synthesis of vascular endothelial growth factor</title><title>Molecular and cellular biochemistry</title><addtitle>Mol Cell Biochem</addtitle><description>Nitric oxide (NO) and reactive oxygen species (ROS) are emerging as important regulators of angiogenesis. NO enhances VEGF synthesis in several cell types and is required for execution of VEGF angiogenic effect in endothelial cells. Similarly, hydrogen peroxide induces VEGF synthesis and recent studies indicate the involvement of ROS in signaling downstream of VEGF stimulation. VEGF synthesis can not only be enhanced by gene transfer of VEGF but also by overexpression of NO synthase genes. Here, we examined the possibility of augmentation of VEGF production by gene transfer of copper/zinc superoxide dismutase (CuZnSOD, SOD1). Overexpression of human SOD1 in mouse NIH 3T3 fibroblasts increased SOD activity, enhanced intracellular generation of H2O2 and significantly stimulated VEGF production as determined by increase in VEGF promoter activity, VEGF mRNA expression and VEGF protein synthesis. The stimulatory effect on VEGF synthesis induced by SOD1 gene transfer was reverted by overexpression of human catalase. The effect of H2O2 produced by engineered cells is mediated by activation of hypoxia-inducible factor response element (HRE) as well as Sp1 recognition site of VEGF promoter. This data suggest the feasibility of stimulation of angiogenesis by overexpression of SOD1.</description><subject>Angiogenesis</subject><subject>Animals</subject><subject>beta-Galactosidase - metabolism</subject><subject>Blotting, Northern</subject><subject>Blotting, Western</subject><subject>Catalase - metabolism</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Gene Transfer Techniques</subject><subject>Genes</subject><subject>Genetic Therapy - methods</subject><subject>Genetic Vectors</subject><subject>Humans</subject><subject>Hydrogen peroxide</subject><subject>Hydrogen Peroxide - pharmacology</subject><subject>Hypoxia</subject><subject>Mice</subject><subject>Neovascularization, Physiologic</subject><subject>NIH 3T3 Cells</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - metabolism</subject><subject>Plasmids - metabolism</subject><subject>Promoter Regions, Genetic</subject><subject>Protein synthesis</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Response Elements</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Rodents</subject><subject>Signal Transduction</subject><subject>Sp1 Transcription Factor - metabolism</subject><subject>Superoxide Dismutase - genetics</subject><subject>Superoxides - metabolism</subject><subject>Transfection</subject><subject>Vascular endothelial growth factor</subject><subject>Vascular Endothelial Growth Factor A - biosynthesis</subject><subject>Vascular Endothelial Growth Factor A - metabolism</subject><issn>0300-8177</issn><issn>1573-4919</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkU1r3DAQhkVpabZp_0IRObQnb0fWx8i5dZc2CSTk0l56EVppnHXw2lvJTpt_X7tZCOSQCMHA8IxeRg9jJwKWAkr5ZXV6tV5dLGE-SklrlkqDVkuEV2whNMpCVaJ6zRYgAQorEI_Yu5xvAcR0xVt2JLRWCpRZsJsz6ogPyXe5psT7mq_HXx3P455S_7eJxGOTd-PgM3Hqtr4LlPmwJZ7vu6nkJs8zdz6HsfVpQmI_tdvGt_wm9X-GLa99GPr0nr2pfZvpw6Ees5_fv_1YnxeX12cX66-XRVCgh8LXGkmCLD3E2isrKNoAZgNxQ9oajJWyIYCsECEYUQNq7aWmjdERTSzlMfv88O4-9b9HyoPbNTlQ2_qO-jE7qw2a6Y9m8tOzpEHAElG9CJZCVKXVMIEnT8DbfkzdtK5DbUqlUNsJOn2AQupzTlS7fWp2Pt07AW7W61Zu1use9br_eh3OCR8PCeNmR_Fx9OBT_gO7raF2</recordid><startdate>20040901</startdate><enddate>20040901</enddate><creator>Grzenkowicz-Wydra, Jolanta</creator><creator>Cisowski, Jarosław</creator><creator>Nakonieczna, Joanna</creator><creator>Zarebski, Adrian</creator><creator>Udilova, Natalia</creator><creator>Nohl, Hans</creator><creator>Józkowicz, Alicja</creator><creator>Podhajska, Anna</creator><creator>Dulak, Józef</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20040901</creationdate><title>Gene transfer of CuZn superoxide dismutase enhances the synthesis of vascular endothelial growth factor</title><author>Grzenkowicz-Wydra, Jolanta ; Cisowski, Jarosław ; Nakonieczna, Joanna ; Zarebski, Adrian ; Udilova, Natalia ; Nohl, Hans ; Józkowicz, Alicja ; Podhajska, Anna ; Dulak, Józef</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-af57e3032a0dfa481ed8c06b0dbe5867d948cc039770c61f0755a35eb65d76d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Angiogenesis</topic><topic>Animals</topic><topic>beta-Galactosidase - metabolism</topic><topic>Blotting, Northern</topic><topic>Blotting, Western</topic><topic>Catalase - metabolism</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Gene Transfer Techniques</topic><topic>Genes</topic><topic>Genetic Therapy - methods</topic><topic>Genetic Vectors</topic><topic>Humans</topic><topic>Hydrogen peroxide</topic><topic>Hydrogen Peroxide - pharmacology</topic><topic>Hypoxia</topic><topic>Mice</topic><topic>Neovascularization, Physiologic</topic><topic>NIH 3T3 Cells</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - metabolism</topic><topic>Plasmids - metabolism</topic><topic>Promoter Regions, Genetic</topic><topic>Protein synthesis</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Response Elements</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Rodents</topic><topic>Signal Transduction</topic><topic>Sp1 Transcription Factor - metabolism</topic><topic>Superoxide Dismutase - genetics</topic><topic>Superoxides - metabolism</topic><topic>Transfection</topic><topic>Vascular endothelial growth factor</topic><topic>Vascular Endothelial Growth Factor A - biosynthesis</topic><topic>Vascular Endothelial Growth Factor A - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grzenkowicz-Wydra, Jolanta</creatorcontrib><creatorcontrib>Cisowski, Jarosław</creatorcontrib><creatorcontrib>Nakonieczna, Joanna</creatorcontrib><creatorcontrib>Zarebski, Adrian</creatorcontrib><creatorcontrib>Udilova, Natalia</creatorcontrib><creatorcontrib>Nohl, Hans</creatorcontrib><creatorcontrib>Józkowicz, Alicja</creatorcontrib><creatorcontrib>Podhajska, Anna</creatorcontrib><creatorcontrib>Dulak, Józef</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular and cellular biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grzenkowicz-Wydra, Jolanta</au><au>Cisowski, Jarosław</au><au>Nakonieczna, Joanna</au><au>Zarebski, Adrian</au><au>Udilova, Natalia</au><au>Nohl, Hans</au><au>Józkowicz, Alicja</au><au>Podhajska, Anna</au><au>Dulak, Józef</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gene transfer of CuZn superoxide dismutase enhances the synthesis of vascular endothelial growth factor</atitle><jtitle>Molecular and cellular biochemistry</jtitle><addtitle>Mol Cell Biochem</addtitle><date>2004-09-01</date><risdate>2004</risdate><volume>264</volume><issue>1-2</issue><spage>169</spage><epage>181</epage><pages>169-181</pages><issn>0300-8177</issn><eissn>1573-4919</eissn><abstract>Nitric oxide (NO) and reactive oxygen species (ROS) are emerging as important regulators of angiogenesis. NO enhances VEGF synthesis in several cell types and is required for execution of VEGF angiogenic effect in endothelial cells. Similarly, hydrogen peroxide induces VEGF synthesis and recent studies indicate the involvement of ROS in signaling downstream of VEGF stimulation. VEGF synthesis can not only be enhanced by gene transfer of VEGF but also by overexpression of NO synthase genes. Here, we examined the possibility of augmentation of VEGF production by gene transfer of copper/zinc superoxide dismutase (CuZnSOD, SOD1). Overexpression of human SOD1 in mouse NIH 3T3 fibroblasts increased SOD activity, enhanced intracellular generation of H2O2 and significantly stimulated VEGF production as determined by increase in VEGF promoter activity, VEGF mRNA expression and VEGF protein synthesis. The stimulatory effect on VEGF synthesis induced by SOD1 gene transfer was reverted by overexpression of human catalase. The effect of H2O2 produced by engineered cells is mediated by activation of hypoxia-inducible factor response element (HRE) as well as Sp1 recognition site of VEGF promoter. This data suggest the feasibility of stimulation of angiogenesis by overexpression of SOD1.</abstract><cop>Netherlands</cop><pub>Springer Nature B.V</pub><pmid>15544046</pmid><doi>10.1023/B:MCBI.0000044386.45054.70</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-8177 |
| ispartof | Molecular and cellular biochemistry, 2004-09, Vol.264 (1-2), p.169-181 |
| issn | 0300-8177 1573-4919 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_856761572 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Angiogenesis Animals beta-Galactosidase - metabolism Blotting, Northern Blotting, Western Catalase - metabolism Enzyme-Linked Immunosorbent Assay Gene Transfer Techniques Genes Genetic Therapy - methods Genetic Vectors Humans Hydrogen peroxide Hydrogen Peroxide - pharmacology Hypoxia Mice Neovascularization, Physiologic NIH 3T3 Cells Nitric oxide Nitric Oxide - metabolism Plasmids - metabolism Promoter Regions, Genetic Protein synthesis Reactive Oxygen Species - metabolism Response Elements Reverse Transcriptase Polymerase Chain Reaction Rodents Signal Transduction Sp1 Transcription Factor - metabolism Superoxide Dismutase - genetics Superoxides - metabolism Transfection Vascular endothelial growth factor Vascular Endothelial Growth Factor A - biosynthesis Vascular Endothelial Growth Factor A - metabolism |
| title | Gene transfer of CuZn superoxide dismutase enhances the synthesis of vascular endothelial growth factor |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T19%3A05%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Gene%20transfer%20of%20CuZn%20superoxide%20dismutase%20enhances%20the%20synthesis%20of%20vascular%20endothelial%20growth%20factor&rft.jtitle=Molecular%20and%20cellular%20biochemistry&rft.au=Grzenkowicz-Wydra,%20Jolanta&rft.date=2004-09-01&rft.volume=264&rft.issue=1-2&rft.spage=169&rft.epage=181&rft.pages=169-181&rft.issn=0300-8177&rft.eissn=1573-4919&rft_id=info:doi/10.1023/B:MCBI.0000044386.45054.70&rft_dat=%3Cproquest_cross%3E856761572%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=756244758&rft_id=info:pmid/15544046&rfr_iscdi=true |