The myocardial protein S100A1 plays a role in the maintenance of normal gene expression in the adult heart

S100A1 and S100B are members of a family of 20 kDa Ca2+-binding homodimers that play a role in signal transduction in mammalian cells. S100A1 is the major isoform in normal heart and S100B, normally a brain protein, is induced in hypertrophic myocardium and functions as an intrinsic negative modulat...

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Veröffentlicht in:	Molecular and cellular biochemistry 2003-01, Vol.242 (1-2), p.27-33
Hauptverfasser:	Tsoporis, James N, Marks, Alexander, Zimmer, Danna B, McMahon, Chris, Parker, Thomas G
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - genetics Animals Aorta - metabolism Aorta - pathology Cells, Cultured Gene Expression Regulation - drug effects Heart attacks Humans Major Histocompatibility Complex - genetics Myocardial infarction Myocytes, Cardiac - metabolism Promoter Regions, Genetic - genetics Proteins Rats Rats, Sprague-Dawley RNA, Messenger - genetics RNA, Messenger - metabolism Rodents S100 Proteins - genetics S100 Proteins - metabolism Signal transduction
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