Upstream open reading frames regulate the cell cycle-dependent expression of the RNA helicase Rok1 in Saccharomyces cerevisiae

The RNA helicase Rok1 plays a role in rRNA processing and in control of cell cycle progression in Saccharomyces cerevisiae. We identified two upstream open reading frames (uORFs) within the ROK1 5′ untranslated region, which inhibited Rok1 translation. Mutating uATG to uAAG or generation of a premat...

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Veröffentlicht in:	FEBS letters 2010-11, Vol.584 (22), p.4593-4598
Hauptverfasser:	Jeon, Soonmee, Kim, Jinmi
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Untranslated Regions - genetics Base Sequence Cell Cycle - genetics Cell cycle progression DEAD-box RNA Helicases - genetics G1 Phase - genetics G1/S progression Gene Expression Regulation, Fungal - genetics Molecular Sequence Data Mutation Open Reading Frames - genetics Protein Biosynthesis - genetics ROK1 S Phase - genetics Saccharomyces cerevisiae Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins - genetics Translation inhibition uORF
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