Differential activation of NF-κB and nitric oxide in lymphocytes regulates in vitro and in vivo radiosensitivity

Lymphocytes are more sensitive to radiation in vivo than in vitro. However, the mechanism of this differential response is poorly understood. In the present study, it was found that the lipid peroxidation and cell death were significantly higher in lymphocytes following whole body irradiation (WBI)...

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Veröffentlicht in:	Mutation research 2010-12, Vol.703 (2), p.149-157
Hauptverfasser:	Sharma, Deepak, Sandur, Santosh K., Rashmi, R., Maurya, D.K., Suryavanshi, Shweta, Checker, Rahul, Krishnan, Sunil, Sainis, K.B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Ageing, cell death Animals Apoptosis Biological and medical sciences Cell Line, Tumor Cell physiology Cell Survival - radiation effects Cells, Cultured Dexamethasone - pharmacology DNA Damage - radiation effects Enzyme Activation - radiation effects Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Lipid peroxidation Lipid Peroxidation - radiation effects Lymphocytes - metabolism Lymphocytes - radiation effects Medical sciences Mice Mice, Inbred C57BL Molecular and cellular biology NF-kappa B - metabolism NF-kappa B - pharmacokinetics NF-κB NG-Nitroarginine Methyl Ester - pharmacology Nitric oxide Nitric Oxide - metabolism Nitric Oxide - radiation effects Nitroprusside - pharmacology Proliferation Radiation Tolerance Radiosensitivity Toxicology
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