Different role of the ventral medial prefrontal cortex on modulation of innate and associative learned fear
Abstract Reversible inactivation of the ventral portion of medial prefrontal cortex (vMPFC) of the rat brain has been shown to induce anxiolytic-like effects in animal models based on associative learning. The role of this brain region in situations involving innate fear, however, is still poorly un...
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| Veröffentlicht in: | Neuroscience 2010-12, Vol.171 (3), p.760-768 |
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| creator | Lisboa, S.F Stecchini, M.F Corrêa, F.M.A Guimarães, F.S Resstel, L.B.M |
| description | Abstract Reversible inactivation of the ventral portion of medial prefrontal cortex (vMPFC) of the rat brain has been shown to induce anxiolytic-like effects in animal models based on associative learning. The role of this brain region in situations involving innate fear, however, is still poorly understood, with several contradictory results in the literature. The objective of the present work was to verify in male Wistar rats the effects of vMPFC administration of cobalt chloride (CoCl2 ), a selective inhibitor of synaptic activity, in rats submitted to two models based on innate fear, the elevated plus-maze (EPM) and light-dark box (LDB), comparing the results with those obtained in two models involving associative learning, the contextual fear conditioning (CFC) and Vogel conflict (VCT) tests. The results showed that, whereas CoCl2 induced anxiolytic-like effects in the CFC and VCT tests, it enhanced anxiety in rats submitted to the EPM and LDB. Together these results indicate that the vMPFC plays an important but complex role in the modulation of defensive-related behaviors, which seems to depend on the nature of the anxiety/fear inducing stimuli. |
| doi_str_mv | 10.1016/j.neuroscience.2010.09.048 |
| format | Article |
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The role of this brain region in situations involving innate fear, however, is still poorly understood, with several contradictory results in the literature. The objective of the present work was to verify in male Wistar rats the effects of vMPFC administration of cobalt chloride (CoCl2 ), a selective inhibitor of synaptic activity, in rats submitted to two models based on innate fear, the elevated plus-maze (EPM) and light-dark box (LDB), comparing the results with those obtained in two models involving associative learning, the contextual fear conditioning (CFC) and Vogel conflict (VCT) tests. The results showed that, whereas CoCl2 induced anxiolytic-like effects in the CFC and VCT tests, it enhanced anxiety in rats submitted to the EPM and LDB. Together these results indicate that the vMPFC plays an important but complex role in the modulation of defensive-related behaviors, which seems to depend on the nature of the anxiety/fear inducing stimuli.</description><identifier>ISSN: 0306-4522</identifier><identifier>EISSN: 1873-7544</identifier><identifier>DOI: 10.1016/j.neuroscience.2010.09.048</identifier><identifier>PMID: 20883749</identifier><identifier>CODEN: NRSCDN</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>Animals ; anxiety ; Anxiety Disorders - chemically induced ; Anxiety Disorders - physiopathology ; Association Learning - drug effects ; Association Learning - physiology ; Biological and medical sciences ; Cobalt - toxicity ; fear ; Fear - physiology ; Fundamental and applied biological sciences. Psychology ; infralimbic cortex ; Male ; Models, Animal ; Neurology ; Neurotoxins - toxicity ; Prefrontal Cortex - drug effects ; Prefrontal Cortex - physiology ; prelimbic cortex ; rat ; Rats ; Rats, Wistar ; Synaptic Transmission - drug effects ; Synaptic Transmission - physiology ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience, 2010-12, Vol.171 (3), p.760-768</ispartof><rights>IBRO</rights><rights>2010 IBRO</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 IBRO. Published by Elsevier Ltd. 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The role of this brain region in situations involving innate fear, however, is still poorly understood, with several contradictory results in the literature. The objective of the present work was to verify in male Wistar rats the effects of vMPFC administration of cobalt chloride (CoCl2 ), a selective inhibitor of synaptic activity, in rats submitted to two models based on innate fear, the elevated plus-maze (EPM) and light-dark box (LDB), comparing the results with those obtained in two models involving associative learning, the contextual fear conditioning (CFC) and Vogel conflict (VCT) tests. The results showed that, whereas CoCl2 induced anxiolytic-like effects in the CFC and VCT tests, it enhanced anxiety in rats submitted to the EPM and LDB. Together these results indicate that the vMPFC plays an important but complex role in the modulation of defensive-related behaviors, which seems to depend on the nature of the anxiety/fear inducing stimuli.</description><subject>Animals</subject><subject>anxiety</subject><subject>Anxiety Disorders - chemically induced</subject><subject>Anxiety Disorders - physiopathology</subject><subject>Association Learning - drug effects</subject><subject>Association Learning - physiology</subject><subject>Biological and medical sciences</subject><subject>Cobalt - toxicity</subject><subject>fear</subject><subject>Fear - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>infralimbic cortex</subject><subject>Male</subject><subject>Models, Animal</subject><subject>Neurology</subject><subject>Neurotoxins - toxicity</subject><subject>Prefrontal Cortex - drug effects</subject><subject>Prefrontal Cortex - physiology</subject><subject>prelimbic cortex</subject><subject>rat</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Synaptic Transmission - drug effects</subject><subject>Synaptic Transmission - physiology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk2LFDEQhoMo7uzqX5AgiKcZK-kk3e1BWHZdFRY8qOeQSVcwsz3JmHQP7r-3hhk_8KK5VJF66oN6i7HnAlYChHm1WSWcS64-YvK4kkAB6FegugdsIbq2WbZaqYdsAQ2YpdJSnrHzWjdAT6vmMTuT0HVNq_oFu7uOIWDBNPGSR-Q58Okr8j19FDfyLQ6RzK5gKDlN5PpcJvzOc-LbPMyjmyK5lBVTchNylwbuas0-UmSPfERXEg48kH3CHgU3Vnx6shfsy83bz1fvl7cf3324urxdem3kRMP3whmphAPTDgFQtms5NGZwgzbgRYDOB982XgfV-8aAA7323bqVoe9QQnPBXh7r7kr-NmOd7DZWj-PoEua52k6b1oA03b9J6JQ2SgsiXx9JT4uvtA67K3Hryr0VYA-q2I39UxV7UMVCb0kVSn52ajOvaaO_Un_KQMCLE-Cqd2MoLvlYf3ONBmWMJu76yCGtbx-x2FO7IRb0kx1y_L953vxVxo8xRep8h_dYN3kuiQSywlZpwX463NHhjASAkL2B5gfVL8fY</recordid><startdate>20101215</startdate><enddate>20101215</enddate><creator>Lisboa, S.F</creator><creator>Stecchini, M.F</creator><creator>Corrêa, F.M.A</creator><creator>Guimarães, F.S</creator><creator>Resstel, L.B.M</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20101215</creationdate><title>Different role of the ventral medial prefrontal cortex on modulation of innate and associative learned fear</title><author>Lisboa, S.F ; Stecchini, M.F ; Corrêa, F.M.A ; Guimarães, F.S ; Resstel, L.B.M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c562t-7591a6241a067df0e27b2d36dad560c1f08cfc73c5f49c360a05bc8b72f98e203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>anxiety</topic><topic>Anxiety Disorders - chemically induced</topic><topic>Anxiety Disorders - physiopathology</topic><topic>Association Learning - drug effects</topic><topic>Association Learning - physiology</topic><topic>Biological and medical sciences</topic><topic>Cobalt - toxicity</topic><topic>fear</topic><topic>Fear - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>infralimbic cortex</topic><topic>Male</topic><topic>Models, Animal</topic><topic>Neurology</topic><topic>Neurotoxins - toxicity</topic><topic>Prefrontal Cortex - drug effects</topic><topic>Prefrontal Cortex - physiology</topic><topic>prelimbic cortex</topic><topic>rat</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Synaptic Transmission - drug effects</topic><topic>Synaptic Transmission - physiology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lisboa, S.F</creatorcontrib><creatorcontrib>Stecchini, M.F</creatorcontrib><creatorcontrib>Corrêa, F.M.A</creatorcontrib><creatorcontrib>Guimarães, F.S</creatorcontrib><creatorcontrib>Resstel, L.B.M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lisboa, S.F</au><au>Stecchini, M.F</au><au>Corrêa, F.M.A</au><au>Guimarães, F.S</au><au>Resstel, L.B.M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Different role of the ventral medial prefrontal cortex on modulation of innate and associative learned fear</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>2010-12-15</date><risdate>2010</risdate><volume>171</volume><issue>3</issue><spage>760</spage><epage>768</epage><pages>760-768</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><coden>NRSCDN</coden><abstract>Abstract Reversible inactivation of the ventral portion of medial prefrontal cortex (vMPFC) of the rat brain has been shown to induce anxiolytic-like effects in animal models based on associative learning. The role of this brain region in situations involving innate fear, however, is still poorly understood, with several contradictory results in the literature. The objective of the present work was to verify in male Wistar rats the effects of vMPFC administration of cobalt chloride (CoCl2 ), a selective inhibitor of synaptic activity, in rats submitted to two models based on innate fear, the elevated plus-maze (EPM) and light-dark box (LDB), comparing the results with those obtained in two models involving associative learning, the contextual fear conditioning (CFC) and Vogel conflict (VCT) tests. The results showed that, whereas CoCl2 induced anxiolytic-like effects in the CFC and VCT tests, it enhanced anxiety in rats submitted to the EPM and LDB. 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| subjects | Animals anxiety Anxiety Disorders - chemically induced Anxiety Disorders - physiopathology Association Learning - drug effects Association Learning - physiology Biological and medical sciences Cobalt - toxicity fear Fear - physiology Fundamental and applied biological sciences. Psychology infralimbic cortex Male Models, Animal Neurology Neurotoxins - toxicity Prefrontal Cortex - drug effects Prefrontal Cortex - physiology prelimbic cortex rat Rats Rats, Wistar Synaptic Transmission - drug effects Synaptic Transmission - physiology Vertebrates: nervous system and sense organs |
| title | Different role of the ventral medial prefrontal cortex on modulation of innate and associative learned fear |
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