Platelet-derived growth factor BB promotes the migration of bone marrow-derived mesenchymal stem cells towards C6 glioma and up-regulates the expression of intracellular adhesion molecule-1

Recent studies have indicated that bone marrow-derived mesenchymal stem cells (BMSCs) have the capacity of migrating towards gliomas. However, few data are available about the molecular mechanism responsible for this migratory capacity. The aim of our study was to investigate the role of platelet-de...

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Veröffentlicht in:	Neuroscience letters 2009-02, Vol.451 (1), p.52-56
Hauptverfasser:	Cheng, Peng, Gao, Zhi-qiang, Liu, Yun-hui, Xue, Yi-xue
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibodies - pharmacology Biological and medical sciences Brain Neoplasms - metabolism Cell Adhesion - drug effects Cell Adhesion - physiology Cell Line, Tumor Cell Movement - drug effects Cell Movement - physiology Cells, Cultured Culture Media, Conditioned - pharmacology Dose-Response Relationship, Drug Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Glioma Glioma - metabolism Intercellular adhesion molecule-1 Intercellular Adhesion Molecule-1 - drug effects Intercellular Adhesion Molecule-1 - genetics Intercellular Adhesion Molecule-1 - metabolism Male Mesenchymal stem cells Mesenchymal Stromal Cells - drug effects Mesenchymal Stromal Cells - metabolism Migration p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases - metabolism Platelet-derived growth factor Platelet-Derived Growth Factor - antagonists & inhibitors Platelet-Derived Growth Factor - metabolism Platelet-Derived Growth Factor - pharmacology Proto-Oncogene Proteins c-sis Rats Rats, Wistar Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - drug effects RNA, Messenger - metabolism Up-Regulation - drug effects Up-Regulation - physiology Vertebrates: nervous system and sense organs
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