The insulin gene VNTR is associated with fasting insulin levels and development of juvenile obesity

In millions of people, obesity leads to type 2 diabetes (T2D; also known as non-insulin-dependent diabetes mellitus). During the early stages of juvenile obesity, the increase of insulin secretion in proportion to accumulated fat balances insulin resistance and protects patients from hyperglycaemia....

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Veröffentlicht in:	Nature genetics 2000-12, Vol.26 (4), p.444-446
Hauptverfasser:	Bougnères, Pierre, Le Stunff, Catherine, Fallin, Daniele, Schork, Nicholas J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Agriculture Alleles Animal Genetics and Genomics Biological and medical sciences Biomedical and Life Sciences Biomedicine Body Mass Index Cancer Research Child Classical genetics, quantitative genetics, hybrids Cohort Studies Complications and side effects Diabetes Diabetes Mellitus, Type 2 - etiology Diabetes Mellitus, Type 2 - genetics Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fasting - blood Fundamental and applied biological sciences. Psychology Gene expression Gene Function Genetic aspects Genetic factors Genetics Genetics of eukaryotes. Biological and molecular evolution Genotype Genotype & phenotype Genotypes Health aspects Human Human Genetics Humans Insulin Insulin - blood Insulin - genetics Insulin - metabolism Insulin resistance Insulin Secretion letter Linear Models Medical sciences Minisatellite Repeats Obesity Obesity - complications Obesity - genetics Obesity in children Obesity, Morbid - complications Obesity, Morbid - genetics Polymorphism Polymorphism, Single Nucleotide Risk Factors
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