Oxidative-stress markers in blood of lung cancer patients occupationally exposed to carcinogens
The study covered 152 lung cancer patients and 210 controls. The results of the study indicated decreased selenium (Se) concentrations and lowered activity of erythrocyte antioxidant enzymes (glutathione peroxidase, superoxide dismutase, glutathione-S-transferase) in the blood of lung cancer patient...
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| Veröffentlicht in: | Biological trace element research 2003-03, Vol.91 (3), p.203-215 |
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| creator | Gromadzinska, J Wasowicz, W Rydzynski, K Szeszenia-Dabrowska, N |
| description | The study covered 152 lung cancer patients and 210 controls. The results of the study indicated decreased selenium (Se) concentrations and lowered activity of erythrocyte antioxidant enzymes (glutathione peroxidase, superoxide dismutase, glutathione-S-transferase) in the blood of lung cancer patients, as well as significantly increased concentrations of vitamin E in erythrocytes and thiobarbituric acid reactive substances in the plasma of the study population. Low plasma Se concentrations (< 45.7 microg/L) enhance the estimated risk of lung cancer (odds ratio = 3.047, p < 0.001). A more precise exposure assessment is required to identify the association between lung cancer incidence and occupational exposure to carcinogens. |
| doi_str_mv | 10.1385/BTER:91:3:203 |
| format | Article |
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The results of the study indicated decreased selenium (Se) concentrations and lowered activity of erythrocyte antioxidant enzymes (glutathione peroxidase, superoxide dismutase, glutathione-S-transferase) in the blood of lung cancer patients, as well as significantly increased concentrations of vitamin E in erythrocytes and thiobarbituric acid reactive substances in the plasma of the study population. Low plasma Se concentrations (< 45.7 microg/L) enhance the estimated risk of lung cancer (odds ratio = 3.047, p < 0.001). A more precise exposure assessment is required to identify the association between lung cancer incidence and occupational exposure to carcinogens.</description><identifier>ISSN: 0163-4984</identifier><identifier>EISSN: 0163-4984</identifier><identifier>EISSN: 1559-0720</identifier><identifier>DOI: 10.1385/BTER:91:3:203</identifier><identifier>PMID: 12663945</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Adult ; Aged ; Antioxidants ; Biomarkers ; Biomarkers - blood ; Blood ; Cancer ; Carcinogens ; Carcinogens, Environmental - adverse effects ; Enzymes ; Erythrocytes ; Erythrocytes - enzymology ; Female ; Glutathione peroxidase ; Glutathione Peroxidase - metabolism ; Glutathione transferase ; Glutathione Transferase - metabolism ; Humans ; Lung cancer ; Lung Neoplasms - blood ; Lung Neoplasms - etiology ; Lung Neoplasms - metabolism ; Male ; Medical research ; Middle Aged ; Occupational Diseases - blood ; Occupational Diseases - etiology ; Occupational Diseases - metabolism ; Occupational exposure ; Occupational Exposure - adverse effects ; Oxidative stress ; Oxidative Stress - drug effects ; Population studies ; Selenium ; Selenium - blood ; Superoxide dismutase ; Superoxide Dismutase - metabolism ; thiobarbituric acid ; Thiobarbituric Acid Reactive Substances - metabolism ; Trace elements ; Vitamin E</subject><ispartof>Biological trace element research, 2003-03, Vol.91 (3), p.203-215</ispartof><rights>Humana Press Inc. 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c379t-8699ed0bf72f4c0a7291be9fdb174e4bb6d93b538a7ca4bda622775a99f631843</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12663945$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gromadzinska, J</creatorcontrib><creatorcontrib>Wasowicz, W</creatorcontrib><creatorcontrib>Rydzynski, K</creatorcontrib><creatorcontrib>Szeszenia-Dabrowska, N</creatorcontrib><title>Oxidative-stress markers in blood of lung cancer patients occupationally exposed to carcinogens</title><title>Biological trace element research</title><addtitle>Biol Trace Elem Res</addtitle><description>The study covered 152 lung cancer patients and 210 controls. The results of the study indicated decreased selenium (Se) concentrations and lowered activity of erythrocyte antioxidant enzymes (glutathione peroxidase, superoxide dismutase, glutathione-S-transferase) in the blood of lung cancer patients, as well as significantly increased concentrations of vitamin E in erythrocytes and thiobarbituric acid reactive substances in the plasma of the study population. Low plasma Se concentrations (< 45.7 microg/L) enhance the estimated risk of lung cancer (odds ratio = 3.047, p < 0.001). A more precise exposure assessment is required to identify the association between lung cancer incidence and occupational exposure to carcinogens.</description><subject>Adult</subject><subject>Aged</subject><subject>Antioxidants</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Blood</subject><subject>Cancer</subject><subject>Carcinogens</subject><subject>Carcinogens, Environmental - adverse effects</subject><subject>Enzymes</subject><subject>Erythrocytes</subject><subject>Erythrocytes - enzymology</subject><subject>Female</subject><subject>Glutathione peroxidase</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>Glutathione transferase</subject><subject>Glutathione Transferase - metabolism</subject><subject>Humans</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - blood</subject><subject>Lung Neoplasms - etiology</subject><subject>Lung Neoplasms - metabolism</subject><subject>Male</subject><subject>Medical research</subject><subject>Middle Aged</subject><subject>Occupational Diseases - blood</subject><subject>Occupational Diseases - etiology</subject><subject>Occupational Diseases - metabolism</subject><subject>Occupational exposure</subject><subject>Occupational Exposure - adverse effects</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Population studies</subject><subject>Selenium</subject><subject>Selenium - blood</subject><subject>Superoxide dismutase</subject><subject>Superoxide Dismutase - metabolism</subject><subject>thiobarbituric acid</subject><subject>Thiobarbituric Acid Reactive Substances - metabolism</subject><subject>Trace elements</subject><subject>Vitamin E</subject><issn>0163-4984</issn><issn>0163-4984</issn><issn>1559-0720</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp90c1LwzAYBvAgih_To1cJHvRUzUfbJLvpmB8gCDLPIUnfSrVrZtLK9t-bsYHiwVMS-PEkbx6ETim5olwW17ez6ctY0TEfM8J30CGhJc9yJfPdX_sDdBTjOyFUMMX30QFlZclVXhwi_bxsKtM3X5DFPkCMeG7CB4SImw7b1vsK-xq3Q_eGnekcBLxIGro-Yu_csD74zrTtCsNy4SNUuPdJBtd0_g26eIz2atNGONmuI_R6N51NHrKn5_vHyc1T5rhQfSZLpaAithaszh0x6Z3UgqorS0UOubVlpbgtuDTCmdxWpmRMiMIoVZecypyP0OUmdxH85wCx1_MmOmhb04EfopZFKQqlGEvy4l9JpSSSM5Hg-R_47oeQho2apSupUmSdlm2QCz7GALVehCZ94UpTotcF6XVBWlHNdSoo-bNt6GDnUP3obSP8G9IdjIM</recordid><startdate>20030301</startdate><enddate>20030301</enddate><creator>Gromadzinska, J</creator><creator>Wasowicz, W</creator><creator>Rydzynski, K</creator><creator>Szeszenia-Dabrowska, N</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QH</scope><scope>7QP</scope><scope>7TN</scope><scope>7U7</scope><scope>7UA</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H97</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L.G</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PCBAR</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7T2</scope><scope>7U2</scope></search><sort><creationdate>20030301</creationdate><title>Oxidative-stress markers in blood of lung cancer patients occupationally exposed to carcinogens</title><author>Gromadzinska, J ; Wasowicz, W ; Rydzynski, K ; Szeszenia-Dabrowska, N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c379t-8699ed0bf72f4c0a7291be9fdb174e4bb6d93b538a7ca4bda622775a99f631843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antioxidants</topic><topic>Biomarkers</topic><topic>Biomarkers - 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The results of the study indicated decreased selenium (Se) concentrations and lowered activity of erythrocyte antioxidant enzymes (glutathione peroxidase, superoxide dismutase, glutathione-S-transferase) in the blood of lung cancer patients, as well as significantly increased concentrations of vitamin E in erythrocytes and thiobarbituric acid reactive substances in the plasma of the study population. Low plasma Se concentrations (< 45.7 microg/L) enhance the estimated risk of lung cancer (odds ratio = 3.047, p < 0.001). A more precise exposure assessment is required to identify the association between lung cancer incidence and occupational exposure to carcinogens.</abstract><cop>United States</cop><pub>Springer Nature B.V</pub><pmid>12663945</pmid><doi>10.1385/BTER:91:3:203</doi><tpages>13</tpages></addata></record> |
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| subjects | Adult Aged Antioxidants Biomarkers Biomarkers - blood Blood Cancer Carcinogens Carcinogens, Environmental - adverse effects Enzymes Erythrocytes Erythrocytes - enzymology Female Glutathione peroxidase Glutathione Peroxidase - metabolism Glutathione transferase Glutathione Transferase - metabolism Humans Lung cancer Lung Neoplasms - blood Lung Neoplasms - etiology Lung Neoplasms - metabolism Male Medical research Middle Aged Occupational Diseases - blood Occupational Diseases - etiology Occupational Diseases - metabolism Occupational exposure Occupational Exposure - adverse effects Oxidative stress Oxidative Stress - drug effects Population studies Selenium Selenium - blood Superoxide dismutase Superoxide Dismutase - metabolism thiobarbituric acid Thiobarbituric Acid Reactive Substances - metabolism Trace elements Vitamin E |
| title | Oxidative-stress markers in blood of lung cancer patients occupationally exposed to carcinogens |
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