Myosin X regulates netrin receptors and functions in axonal path-finding
Netrins regulate axon path-finding during development, but the underlying mechanisms are not well understood. Here, we provide evidence for the involvement of the unconventional myosin X (Myo X) in netrin-1 function. We find that Myo X interacts with the netrin receptor deleted in colorectal cancer...
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| Veröffentlicht in: | Nature cell biology 2007-02, Vol.9 (2), p.184-192 |
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| creator | Zhu, Xiao-Juan Wang, Cheng-Zhong Dai, Peng-Gao Xie, Yi Song, Ning-Ning Liu, Yu Du, Quan-Sheng Mei, Lin Ding, Yu-Qiang Xiong, Wen-Cheng |
| description | Netrins regulate axon path-finding during development, but the underlying mechanisms are not well understood. Here, we provide evidence for the involvement of the unconventional myosin X (Myo X) in netrin-1 function. We find that Myo X interacts with the netrin receptor deleted in colorectal cancer (DCC) and neogenin, a DCC-related protein. Expression of Myo X redistributes DCC to the cell periphery or to the tips of neurites, whereas its silencing prevents DCC distribution in neurites. Moreover, expression of DCC, but not neogenin, stimulates Myo X-mediated formation and elongation of filopodia, suggesting that Myo X function may be differentially regulated by DCC and neogenin. The involvement of Myo X in netrin-1 function was further supported by the effects of inhibiting Myo X function in neurons. Cortical explants derived from mouse embryos expressing a motor-less Myo X exhibit reduced neurite outgrowth in response to netrin-1 and chick commissural neurons expressing the motor-less Myo X, or in which Myo X is silenced using microRNA (miRNA), show impaired axon projection
in vivo
. Taken together, these results identify a novel role for Myo X in regulating netrin-1 function. |
| doi_str_mv | 10.1038/ncb1535 |
| format | Article |
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in vivo
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in vivo
. Taken together, these results identify a novel role for Myo X in regulating netrin-1 function.</description><subject>Animals</subject><subject>Axons - physiology</subject><subject>Biomedical and Life Sciences</subject><subject>Cancer Research</subject><subject>Cell Biology</subject><subject>Cell Line</subject><subject>Cercopithecus aethiops</subject><subject>Chick Embryo</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>COS Cells</subject><subject>Development and progression</subject><subject>Developmental Biology</subject><subject>Embryos</subject><subject>Genetic aspects</subject><subject>Humans</subject><subject>Kinases</subject><subject>letter</subject><subject>Life Sciences</subject><subject>Membrane Proteins - metabolism</subject><subject>Mice</subject><subject>MicroRNAs</subject><subject>MicroRNAs - pharmacology</subject><subject>Molecular Sequence Data</subject><subject>Myosin</subject><subject>Myosins - drug effects</subject><subject>Myosins - metabolism</subject><subject>Nerve Growth Factors - metabolism</subject><subject>Nerve Growth Factors - pharmacology</subject><subject>Netrin Receptors</subject><subject>Netrin-1</subject><subject>Neurobiology</subject><subject>Neurosciences</subject><subject>Physiological aspects</subject><subject>Proteins</subject><subject>Rats</subject><subject>Receptors, Cell Surface - metabolism</subject><subject>Stem Cells</subject><subject>Tumor Suppressor Proteins - metabolism</subject><subject>Tumor Suppressor Proteins - pharmacology</subject><issn>1465-7392</issn><issn>1476-4679</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqF0ktrHSEUAGApLc2jpf-gDF20zWJSH6OOyxCaJpBQ6AO6G844Z6aGuXqrDiT_voY7EJJFggvF8x3x6CHkHaPHjIr2i7c9k0K-IPus0apulDYv79ZK1loYvkcOUrqmlDUN1a_JHtNcaK35Pjm_ug3J-epPFXFaZsiYKo85lq2IFrc5xFSBH6px8Ta74FNVQnATPMzVFvLfenR-cH56Q16NMCd8u86H5PfZ11-n5_Xl928XpyeXtW20zDVwpC2HHrjmLZW9GJEyisL0AAY4CCtGARIHM1DNJDAU3DbKSmstNxrFIfm0O3cbw78FU-42LlmcZ_AYltS1UmlpDFNFfnxSqtYoIal8FjIjpRANL_DDI3gdllheInWcc9G2zLCCjndoghk758eQI9gyBtw4GzyOruyfsFZQqZSgJeHoQUIxGW_yBEtK3cXPHw_tWr2NIaWIY7eNbgPxtmO0u-uEbu2EIt-vd136DQ73bv36Aj7vQCohP2G8L-bxWf8BtlC5WA</recordid><startdate>20070201</startdate><enddate>20070201</enddate><creator>Zhu, Xiao-Juan</creator><creator>Wang, Cheng-Zhong</creator><creator>Dai, Peng-Gao</creator><creator>Xie, Yi</creator><creator>Song, Ning-Ning</creator><creator>Liu, Yu</creator><creator>Du, Quan-Sheng</creator><creator>Mei, Lin</creator><creator>Ding, Yu-Qiang</creator><creator>Xiong, Wen-Cheng</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20070201</creationdate><title>Myosin X regulates netrin receptors and functions in axonal path-finding</title><author>Zhu, Xiao-Juan ; Wang, Cheng-Zhong ; Dai, Peng-Gao ; Xie, Yi ; Song, Ning-Ning ; Liu, Yu ; Du, Quan-Sheng ; Mei, Lin ; Ding, Yu-Qiang ; Xiong, Wen-Cheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-a2e082aba272805b3fe010e39baa9a2a3c3f3a5ed9d0715a1e32c46c5ccc297e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Axons - 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Academic</collection><jtitle>Nature cell biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhu, Xiao-Juan</au><au>Wang, Cheng-Zhong</au><au>Dai, Peng-Gao</au><au>Xie, Yi</au><au>Song, Ning-Ning</au><au>Liu, Yu</au><au>Du, Quan-Sheng</au><au>Mei, Lin</au><au>Ding, Yu-Qiang</au><au>Xiong, Wen-Cheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Myosin X regulates netrin receptors and functions in axonal path-finding</atitle><jtitle>Nature cell biology</jtitle><stitle>Nat Cell Biol</stitle><addtitle>Nat Cell Biol</addtitle><date>2007-02-01</date><risdate>2007</risdate><volume>9</volume><issue>2</issue><spage>184</spage><epage>192</epage><pages>184-192</pages><issn>1465-7392</issn><eissn>1476-4679</eissn><abstract>Netrins regulate axon path-finding during development, but the underlying mechanisms are not well understood. Here, we provide evidence for the involvement of the unconventional myosin X (Myo X) in netrin-1 function. We find that Myo X interacts with the netrin receptor deleted in colorectal cancer (DCC) and neogenin, a DCC-related protein. Expression of Myo X redistributes DCC to the cell periphery or to the tips of neurites, whereas its silencing prevents DCC distribution in neurites. Moreover, expression of DCC, but not neogenin, stimulates Myo X-mediated formation and elongation of filopodia, suggesting that Myo X function may be differentially regulated by DCC and neogenin. The involvement of Myo X in netrin-1 function was further supported by the effects of inhibiting Myo X function in neurons. Cortical explants derived from mouse embryos expressing a motor-less Myo X exhibit reduced neurite outgrowth in response to netrin-1 and chick commissural neurons expressing the motor-less Myo X, or in which Myo X is silenced using microRNA (miRNA), show impaired axon projection
in vivo
. Taken together, these results identify a novel role for Myo X in regulating netrin-1 function.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>17237772</pmid><doi>10.1038/ncb1535</doi><tpages>9</tpages></addata></record> |
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| subjects | Animals Axons - physiology Biomedical and Life Sciences Cancer Research Cell Biology Cell Line Cercopithecus aethiops Chick Embryo Colorectal cancer Colorectal carcinoma COS Cells Development and progression Developmental Biology Embryos Genetic aspects Humans Kinases letter Life Sciences Membrane Proteins - metabolism Mice MicroRNAs MicroRNAs - pharmacology Molecular Sequence Data Myosin Myosins - drug effects Myosins - metabolism Nerve Growth Factors - metabolism Nerve Growth Factors - pharmacology Netrin Receptors Netrin-1 Neurobiology Neurosciences Physiological aspects Proteins Rats Receptors, Cell Surface - metabolism Stem Cells Tumor Suppressor Proteins - metabolism Tumor Suppressor Proteins - pharmacology |
| title | Myosin X regulates netrin receptors and functions in axonal path-finding |
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