Interleukin-6 is essential for zwitterionic polysaccharide-mediated abscess formation

Abscess formation associated with secondary peritonitis causes severe morbidity and can be fatal. Formation of abscesses requires the presence of CD4+ T-cells. Zwitterionic polysaccharides (ZPSs) represent a novel class of immunomodulatory bacterial antigens that stimulate CD4+ T-cells in a major hi...

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Veröffentlicht in:	Innate immunity (London, England) England), 2010-10, Vol.16 (5), p.310-321
Hauptverfasser:	Meemboor, Sonja, Mertens, Janina, Flenner, Eva, Groneck, Laura, Zingarelli, Alessandra, Gamstätter, Thomas, Bessler, Martina, Seeger, Jens M., Kashkar, Hamid, Odenthal, Margarete, Kalka-Moll, Wiltrud Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Abscess - immunology Animals Antigen-Presenting Cells - immunology Antigen-Presenting Cells - metabolism Antigen-Presenting Cells - pathology Bacterial Capsules - immunology Bacterial Capsules - metabolism CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD4-Positive T-Lymphocytes - pathology Cell Movement Cell Survival Dendritic Cells - immunology Dendritic Cells - metabolism Dendritic Cells - pathology Histocompatibility Antigens Class II - metabolism Humans Mice Mice, Inbred C57BL Models, Animal Peritoneal Cavity - pathology Polysaccharides, Bacterial - chemistry Polysaccharides, Bacterial - immunology Polysaccharides, Bacterial - metabolism Protein Binding Streptococcus pneumoniae Streptococcus pneumoniae - immunology
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