Endogenous nicotinic cholinergic activity regulates dopamine release in the striatum

Dopamine is vital for coordinated motion and for association learning linked to behavioral reinforcement. Here we show that the precise overlap of striatal dopaminergic and cholinergic fibers underlies potent control of dopamine release by ongoing nicotinic receptor activity. In mouse striatal slice...

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Veröffentlicht in:	Nature neuroscience 2001-12, Vol.4 (12), p.1224-1229
Hauptverfasser:	Dani, John A, Zhou, Fu-Ming, Liang, Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - metabolism Acetylcholinesterase - metabolism Action Potentials - drug effects Action Potentials - physiology Animal Genetics and Genomics Animals b2 nicotinic subunit gene Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Calcium - metabolism Carbon Choline O-Acetyltransferase - metabolism Cholinergic Fibers - drug effects Cholinergic Fibers - metabolism Corpus striatum Dopamine Dopamine - metabolism Dopamine - secretion Dopaminergic mechanisms Enzyme Inhibitors - pharmacology Enzymes Immunohistochemistry Mice Mice, Inbred C57BL Muscarinic Antagonists - pharmacology Neostriatum - cytology Neostriatum - drug effects Neostriatum - metabolism Neurobiology Neuromuscular Depolarizing Agents - pharmacology Neurons - drug effects Neurons - metabolism Neurosciences Nicotine Nicotine - pharmacology Nicotinic Antagonists - pharmacology Nicotinic receptors Positive reinforcement Properties Publishing Receptors, Nicotinic - drug effects Receptors, Nicotinic - metabolism Smoking - metabolism Smoking - physiopathology Synaptic Transmission - drug effects Synaptic Transmission - physiology Tetrodotoxin - pharmacology Tyrosine 3-Monooxygenase - metabolism Voltammetry
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