COUP-TFI regulates the balance of cortical patterning between frontal/motor and sensory areas

We used cortex-specific deletion of the transcription factor gene COUP-TFI (also known as Nr2f1 ) in mice to demonstrate previously unknown fundamental roles for it in patterning mammalian neocortex into areas. The highest COUP-TFI expression is observed in the cortical progenitors and progeny in pa...

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Veröffentlicht in:	Nature neuroscience 2007-10, Vol.10 (10), p.1277-1286
Hauptverfasser:	Armentano, Maria, Chou, Shen-Ju, Srubek Tomassy, Giulio, Leingärtner, Axel, O'Leary, Dennis D M, Studer, Michèle
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Genetics and Genomics Animals Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Body Patterning - genetics Body Patterning - physiology COUP Transcription Factor I - genetics COUP Transcription Factor I - physiology Embryo, Mammalian Fibroblast Growth Factor 8 - metabolism Gene expression Gene Expression Regulation, Developmental - physiology Genetic transcription Homeodomain Proteins - metabolism Mice Mice, Inbred C57BL Mice, Transgenic Motor Cortex - cytology Motor Cortex - embryology Motor Cortex - metabolism Neocortex Neural Pathways - cytology Neural Pathways - embryology Neural Pathways - metabolism Neural transmission Neurobiology Neurosciences PAX2 Transcription Factor - metabolism Regulation Serotonin - metabolism Somatosensory Cortex - embryology Somatosensory Cortex - metabolism Transcription factors Transcription Factors - metabolism
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