COUP-TFI regulates the balance of cortical patterning between frontal/motor and sensory areas
We used cortex-specific deletion of the transcription factor gene COUP-TFI (also known as Nr2f1 ) in mice to demonstrate previously unknown fundamental roles for it in patterning mammalian neocortex into areas. The highest COUP-TFI expression is observed in the cortical progenitors and progeny in pa...
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| Veröffentlicht in: | Nature neuroscience 2007-10, Vol.10 (10), p.1277-1286 |
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| creator | Armentano, Maria Chou, Shen-Ju Srubek Tomassy, Giulio Leingärtner, Axel O'Leary, Dennis D M Studer, Michèle |
| description | We used cortex-specific deletion of the transcription factor gene
COUP-TFI
(also known as
Nr2f1
) in mice to demonstrate previously unknown fundamental roles for it in patterning mammalian neocortex into areas. The highest COUP-TFI expression is observed in the cortical progenitors and progeny in parietal and occipital cortex that form sensory areas, and the lowest expression was observed in frontal cortex that includes motor areas. Cortical deletion of COUP-TFI resulted in massive expansion of frontal areas, including motor, to occupy most of neocortex, paralleled by marked compression of sensory areas to caudal occipital cortex. These area patterning changes are preceded and paralleled by corresponding changes in molecular markers of area identity and altered axonal projections to maintain patterned area-specific input and output connections. We conclude that COUP-TFI is required for balancing patterning of neocortex into frontal/motor and sensory areas by acting in its expression domain to repress frontal/motor area identities and to specify sensory area identities. |
| doi_str_mv | 10.1038/nn1958 |
| format | Article |
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COUP-TFI
(also known as
Nr2f1
) in mice to demonstrate previously unknown fundamental roles for it in patterning mammalian neocortex into areas. The highest COUP-TFI expression is observed in the cortical progenitors and progeny in parietal and occipital cortex that form sensory areas, and the lowest expression was observed in frontal cortex that includes motor areas. Cortical deletion of COUP-TFI resulted in massive expansion of frontal areas, including motor, to occupy most of neocortex, paralleled by marked compression of sensory areas to caudal occipital cortex. These area patterning changes are preceded and paralleled by corresponding changes in molecular markers of area identity and altered axonal projections to maintain patterned area-specific input and output connections. We conclude that COUP-TFI is required for balancing patterning of neocortex into frontal/motor and sensory areas by acting in its expression domain to repress frontal/motor area identities and to specify sensory area identities.</description><identifier>ISSN: 1097-6256</identifier><identifier>EISSN: 1546-1726</identifier><identifier>DOI: 10.1038/nn1958</identifier><identifier>PMID: 17828260</identifier><identifier>CODEN: NANEFN</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Animal Genetics and Genomics ; Animals ; Behavioral Sciences ; Biological Techniques ; Biomedical and Life Sciences ; Biomedicine ; Body Patterning - genetics ; Body Patterning - physiology ; COUP Transcription Factor I - genetics ; COUP Transcription Factor I - physiology ; Embryo, Mammalian ; Fibroblast Growth Factor 8 - metabolism ; Gene expression ; Gene Expression Regulation, Developmental - physiology ; Genetic transcription ; Homeodomain Proteins - metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Motor Cortex - cytology ; Motor Cortex - embryology ; Motor Cortex - metabolism ; Neocortex ; Neural Pathways - cytology ; Neural Pathways - embryology ; Neural Pathways - metabolism ; Neural transmission ; Neurobiology ; Neurosciences ; PAX2 Transcription Factor - metabolism ; Regulation ; Serotonin - metabolism ; Somatosensory Cortex - embryology ; Somatosensory Cortex - metabolism ; Transcription factors ; Transcription Factors - metabolism</subject><ispartof>Nature neuroscience, 2007-10, Vol.10 (10), p.1277-1286</ispartof><rights>Springer Nature America, Inc. 2007</rights><rights>COPYRIGHT 2007 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Oct 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c538t-e2b751b0e861d1f3b2388ac81d5e2ee7a8481442f4cbe17b1d69848db3b2184e3</citedby><cites>FETCH-LOGICAL-c538t-e2b751b0e861d1f3b2388ac81d5e2ee7a8481442f4cbe17b1d69848db3b2184e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/nn1958$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/nn1958$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17828260$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Armentano, Maria</creatorcontrib><creatorcontrib>Chou, Shen-Ju</creatorcontrib><creatorcontrib>Srubek Tomassy, Giulio</creatorcontrib><creatorcontrib>Leingärtner, Axel</creatorcontrib><creatorcontrib>O'Leary, Dennis D M</creatorcontrib><creatorcontrib>Studer, Michèle</creatorcontrib><title>COUP-TFI regulates the balance of cortical patterning between frontal/motor and sensory areas</title><title>Nature neuroscience</title><addtitle>Nat Neurosci</addtitle><addtitle>Nat Neurosci</addtitle><description>We used cortex-specific deletion of the transcription factor gene
COUP-TFI
(also known as
Nr2f1
) in mice to demonstrate previously unknown fundamental roles for it in patterning mammalian neocortex into areas. The highest COUP-TFI expression is observed in the cortical progenitors and progeny in parietal and occipital cortex that form sensory areas, and the lowest expression was observed in frontal cortex that includes motor areas. Cortical deletion of COUP-TFI resulted in massive expansion of frontal areas, including motor, to occupy most of neocortex, paralleled by marked compression of sensory areas to caudal occipital cortex. These area patterning changes are preceded and paralleled by corresponding changes in molecular markers of area identity and altered axonal projections to maintain patterned area-specific input and output connections. We conclude that COUP-TFI is required for balancing patterning of neocortex into frontal/motor and sensory areas by acting in its expression domain to repress frontal/motor area identities and to specify sensory area identities.</description><subject>Animal Genetics and Genomics</subject><subject>Animals</subject><subject>Behavioral Sciences</subject><subject>Biological Techniques</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Body Patterning - genetics</subject><subject>Body Patterning - physiology</subject><subject>COUP Transcription Factor I - genetics</subject><subject>COUP Transcription Factor I - physiology</subject><subject>Embryo, Mammalian</subject><subject>Fibroblast Growth Factor 8 - metabolism</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Developmental - physiology</subject><subject>Genetic transcription</subject><subject>Homeodomain Proteins - metabolism</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Transgenic</subject><subject>Motor Cortex - cytology</subject><subject>Motor Cortex - embryology</subject><subject>Motor Cortex - metabolism</subject><subject>Neocortex</subject><subject>Neural Pathways - cytology</subject><subject>Neural Pathways - embryology</subject><subject>Neural Pathways - metabolism</subject><subject>Neural transmission</subject><subject>Neurobiology</subject><subject>Neurosciences</subject><subject>PAX2 Transcription Factor - metabolism</subject><subject>Regulation</subject><subject>Serotonin - metabolism</subject><subject>Somatosensory Cortex - embryology</subject><subject>Somatosensory Cortex - metabolism</subject><subject>Transcription factors</subject><subject>Transcription Factors - metabolism</subject><issn>1097-6256</issn><issn>1546-1726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkk9r3DAQxU1padK0_QhF9JDSgxNJ1t9jWJpkIZCQJsdiJHnsOtjSVpJp8-2rsAtLcmjRQWL0m8e84VXVR4JPCG7UqfdEc_WqOiSciZpIKl6XN9ayFpSLg-pdSg8YY8mVflsdEKmoogIfVj9W1_c39d35GkUYlslkSCj_BGTNZLwDFHrkQsyjMxPamJwh-tEPyEL-DeBRH4PPZjqdQw4RGd-hBD6F-IhMBJPeV296MyX4sLuPqvvzb3ery_rq-mK9OruqHW9UroFayYnFoATpSN9Y2ihlnCIdBwogjWKKMEZ75iwQaUkndCl1tpBEMWiOqi9b3U0MvxZIuZ3H5GAqHiAsqVVcSK4xp4U8_icpVIM1I81_QSKFLpJPip9fgA9hib7YbalkkjKGWYFOttBgJmhH34ccjSung3l0wUM_lvoZUUJo3DBdGr4-ayhMhj95MEtK7fr77XN2N6qLIaUIfbuJ42ziY0tw-5SOdpuOAn7ajbrYGbo9tovDfo-pfPkB4t7LC6m_OhG_GA</recordid><startdate>20071001</startdate><enddate>20071001</enddate><creator>Armentano, Maria</creator><creator>Chou, Shen-Ju</creator><creator>Srubek Tomassy, Giulio</creator><creator>Leingärtner, Axel</creator><creator>O'Leary, Dennis D M</creator><creator>Studer, Michèle</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20071001</creationdate><title>COUP-TFI regulates the balance of cortical patterning between frontal/motor and sensory areas</title><author>Armentano, Maria ; Chou, Shen-Ju ; Srubek Tomassy, Giulio ; Leingärtner, Axel ; O'Leary, Dennis D M ; Studer, Michèle</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c538t-e2b751b0e861d1f3b2388ac81d5e2ee7a8481442f4cbe17b1d69848db3b2184e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animal Genetics and Genomics</topic><topic>Animals</topic><topic>Behavioral Sciences</topic><topic>Biological Techniques</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Body Patterning - genetics</topic><topic>Body Patterning - physiology</topic><topic>COUP Transcription Factor I - genetics</topic><topic>COUP Transcription Factor I - physiology</topic><topic>Embryo, Mammalian</topic><topic>Fibroblast Growth Factor 8 - metabolism</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Developmental - physiology</topic><topic>Genetic transcription</topic><topic>Homeodomain Proteins - metabolism</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Transgenic</topic><topic>Motor Cortex - cytology</topic><topic>Motor Cortex - embryology</topic><topic>Motor Cortex - metabolism</topic><topic>Neocortex</topic><topic>Neural Pathways - cytology</topic><topic>Neural Pathways - embryology</topic><topic>Neural Pathways - metabolism</topic><topic>Neural transmission</topic><topic>Neurobiology</topic><topic>Neurosciences</topic><topic>PAX2 Transcription Factor - metabolism</topic><topic>Regulation</topic><topic>Serotonin - metabolism</topic><topic>Somatosensory Cortex - embryology</topic><topic>Somatosensory Cortex - metabolism</topic><topic>Transcription factors</topic><topic>Transcription Factors - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Armentano, Maria</creatorcontrib><creatorcontrib>Chou, Shen-Ju</creatorcontrib><creatorcontrib>Srubek Tomassy, Giulio</creatorcontrib><creatorcontrib>Leingärtner, Axel</creatorcontrib><creatorcontrib>O'Leary, Dennis D M</creatorcontrib><creatorcontrib>Studer, Michèle</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Armentano, Maria</au><au>Chou, Shen-Ju</au><au>Srubek Tomassy, Giulio</au><au>Leingärtner, Axel</au><au>O'Leary, Dennis D M</au><au>Studer, Michèle</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>COUP-TFI regulates the balance of cortical patterning between frontal/motor and sensory areas</atitle><jtitle>Nature neuroscience</jtitle><stitle>Nat Neurosci</stitle><addtitle>Nat Neurosci</addtitle><date>2007-10-01</date><risdate>2007</risdate><volume>10</volume><issue>10</issue><spage>1277</spage><epage>1286</epage><pages>1277-1286</pages><issn>1097-6256</issn><eissn>1546-1726</eissn><coden>NANEFN</coden><abstract>We used cortex-specific deletion of the transcription factor gene
COUP-TFI
(also known as
Nr2f1
) in mice to demonstrate previously unknown fundamental roles for it in patterning mammalian neocortex into areas. The highest COUP-TFI expression is observed in the cortical progenitors and progeny in parietal and occipital cortex that form sensory areas, and the lowest expression was observed in frontal cortex that includes motor areas. Cortical deletion of COUP-TFI resulted in massive expansion of frontal areas, including motor, to occupy most of neocortex, paralleled by marked compression of sensory areas to caudal occipital cortex. These area patterning changes are preceded and paralleled by corresponding changes in molecular markers of area identity and altered axonal projections to maintain patterned area-specific input and output connections. We conclude that COUP-TFI is required for balancing patterning of neocortex into frontal/motor and sensory areas by acting in its expression domain to repress frontal/motor area identities and to specify sensory area identities.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>17828260</pmid><doi>10.1038/nn1958</doi><tpages>10</tpages></addata></record> |
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| subjects | Animal Genetics and Genomics Animals Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Body Patterning - genetics Body Patterning - physiology COUP Transcription Factor I - genetics COUP Transcription Factor I - physiology Embryo, Mammalian Fibroblast Growth Factor 8 - metabolism Gene expression Gene Expression Regulation, Developmental - physiology Genetic transcription Homeodomain Proteins - metabolism Mice Mice, Inbred C57BL Mice, Transgenic Motor Cortex - cytology Motor Cortex - embryology Motor Cortex - metabolism Neocortex Neural Pathways - cytology Neural Pathways - embryology Neural Pathways - metabolism Neural transmission Neurobiology Neurosciences PAX2 Transcription Factor - metabolism Regulation Serotonin - metabolism Somatosensory Cortex - embryology Somatosensory Cortex - metabolism Transcription factors Transcription Factors - metabolism |
| title | COUP-TFI regulates the balance of cortical patterning between frontal/motor and sensory areas |
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