Absolute requirement of GDNF for adult catecholaminergic neuron survival

The exact function of glial cell line–derived neurotrophic factor (GDNF) in catecholaminergic cell survival in adulthood is unclear. Using a conditional GDNF-null mouse that suppresses GDNF expression in adulthood, Pascual et al . show that GDNF is an essential factor whose downregulation results in...

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Veröffentlicht in:	Nature neuroscience 2008-07, Vol.11 (7), p.755-761
Hauptverfasser:	Pascual, Alberto, Hidalgo-Figueroa, María, Piruat, José I, Pintado, C Oscar, Gómez-Díaz, Raquel, López-Barneo, José
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Animal Genetics and Genomics Animals Antineoplastic Agents, Hormonal - toxicity Behavior, Animal - drug effects Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Brain - cytology Care and treatment Catecholamines - metabolism Cell Count - methods Cell Survival - genetics Choline O-Acetyltransferase - metabolism Disease Enzyme-Linked Immunosorbent Assay - methods Gene Expression Regulation - drug effects Gene Expression Regulation - genetics Glial cell line-derived neurotrophic factor Glial Cell Line-Derived Neurotrophic Factor - deficiency Glial Cell Line-Derived Neurotrophic Factor - genetics Glutamate Decarboxylase - metabolism Hypokinesia - genetics Mice Mice, Inbred C57BL Mice, Transgenic Motor Activity - drug effects Neural transmission Neurobiology Neurons Neurons - drug effects Neurons - metabolism Neurosciences Parkinson's disease Phosphopyruvate Hydratase - metabolism Regulation Tamoxifen - toxicity Time Factors Tyrosine 3-Monooxygenase - metabolism
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