Active Immunization with Amyloid-b 1-42 Impairs Memory Performance through TLR2/4-Dependent Activation of the Innate Immune System

Active immunization with amyloid-b (Ab) peptide 1-42 reverses amyloid plaque deposition in the CNS of patients with Alzheimer's disease and in amyloid precursor protein transgenic mice. However, this treatment may also cause severe, life-threatening meningoencephalitis. Physiological responses...

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Veröffentlicht in:	The Journal of immunology (1950) 2010-11, Vol.185 (10), p.6338-6347
Hauptverfasser:	Vollmar, Patrick, Kullmann, Jennifer S, Thilo, Barbara, Claussen, Malte C, Rothhammer, Veit, Jacobi, Hortenzia, Sellner, Johann, Nessler, Stefan, Korn, Thomas, Hemmer, Bernhard
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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