EphB–ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cells

The genes encoding tyrosine kinase receptors EphB2 and EphB3 are β-catenin and Tcf4 target genes in colorectal cancer (CRC) and in normal intestinal cells 1 , 2 . In the intestinal epithelium, EphB signaling controls the positioning of cell types along the crypt-villus axis 1 . In CRC, EphB activity...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature genetics 2007-11, Vol.39 (11), p.1376-1383
Hauptverfasser:	Cortina, Carme, Palomo-Ponce, Sergio, Iglesias, Mar, Fernández-Masip, Juan Luis, Vivancos, Ana, Whissell, Gavin, Humà, Mireia, Peiró, Nerea, Gallego, Lourdes, Jonkheer, Suzanne, Davy, Alice, Lloreta, Josep, Sancho, Elena, Batlle, Eduard
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma - metabolism Adenoma - pathology Adenoma - prevention & control Adhesion Agriculture Animal Genetics and Genomics Animals beta Catenin - metabolism Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer cells Cancer Research Cell adhesion & migration Cell growth Cell Line, Tumor Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Colorectal Neoplasms - prevention & control Development and progression Disease Progression Ephrin-B1 - antagonists & inhibitors Ephrin-B1 - genetics Ephrin-B1 - metabolism Female Fundamental and applied biological sciences. Psychology Gastroenterology. Liver. Pancreas. Abdomen Gene expression Gene Expression Regulation, Neoplastic Gene Function Genes, APC - physiology Genetic aspects Genetic research Genetics of eukaryotes. Biological and molecular evolution Human Genetics Humans Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Intestinal Neoplasms - metabolism Intestinal Neoplasms - pathology Intestinal Neoplasms - prevention & control letter Male Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Molecular and cellular biology Physiological aspects Receptors, Eph Family - antagonists & inhibitors Receptors, Eph Family - genetics Receptors, Eph Family - metabolism Risk factors RNA, Messenger - antagonists & inhibitors RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Subcellular Fractions TCF Transcription Factors - metabolism Transcription Factor 7-Like 2 Protein Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!