A novel ryanodine receptor expressed in pancreatic islets by alternative splicing from type 2 ryanodine receptor gene

Cyclic ADP-ribose (cADPR), a potent Ca2+ mobilizing intracellular messenger synthesized by CD38, regulates the opening of ryanodine receptors (RyRs). Increases in intracellular Ca2+ concentrations in pancreatic islets, resulting from Ca2+ mobilization from RyRs as well as Ca2+ influx from extracellu...

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Veröffentlicht in:	Biochemical and biophysical research communications 2010-06, Vol.397 (2), p.140-145
Hauptverfasser:	Takasawa, Shin, Kuroki, Michio, Nata, Koji, Noguchi, Naoya, Ikeda, Takayuki, Yamauchi, Akiyo, Ota, Hiroyo, Itaya-Hironaka, Asako, Sakuramoto-Tsuchida, Sumiyo, Takahashi, Iwao, Yoshikawa, Takeo, Shimosegawa, Tooru, Okamoto, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Amino Acid Sequence Animals Calcium - metabolism Cell Line Cyclic ADP-ribose Cyclic ADP-Ribose - metabolism DNA - genetics DNA - isolation & purification Gene Library Humans Islets of Langerhans - metabolism Molecular Sequence Data Pancreatic islets Rabbits Rats Ryanodine receptor Ryanodine Receptor Calcium Release Channel - genetics Ryanodine Receptor Calcium Release Channel - metabolism Tissue Distribution
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