Role of serum response factor in the pathogenesis of disease
Serum response factor (SRF) is a ubiquitously expressed transcription factor that binds to a DNA cis element known as the CArG box, which is found in the proximal regulatory regions of over 200 experimentally validated target genes. Genetic deletion of SRF is incompatible with life in a variety of a...
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| Veröffentlicht in: | Laboratory investigation 2010-09, Vol.90 (9), p.1274-1284 |
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| description | Serum response factor (SRF) is a ubiquitously expressed transcription factor that binds to a DNA cis element known as the CArG box, which is found in the proximal regulatory regions of over 200 experimentally validated target genes. Genetic deletion of SRF is incompatible with life in a variety of animals from different phyla. In mice, loss of SRF throughout the early embryo results in gastrulation defects precluding analyses in individual organ systems. Genetic inactivation studies using conditional or inducible promoters directing the expression of the bacteriophage Cre recombinase have shown a vital role for SRF in such cellular processes as contractility, cell migration, synaptic activity, inflammation, and cell survival. A growing number of experimental and human diseases are associated with changes in SRF expression, suggesting that SRF has a role in the pathogenesis of disease. This review summarizes data from experimental model systems and human pathology where SRF expression is either deliberately or naturally altered. |
| doi_str_mv | 10.1038/labinvest.2010.104 |
| format | Article |
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Genetic deletion of SRF is incompatible with life in a variety of animals from different phyla. In mice, loss of SRF throughout the early embryo results in gastrulation defects precluding analyses in individual organ systems. Genetic inactivation studies using conditional or inducible promoters directing the expression of the bacteriophage Cre recombinase have shown a vital role for SRF in such cellular processes as contractility, cell migration, synaptic activity, inflammation, and cell survival. A growing number of experimental and human diseases are associated with changes in SRF expression, suggesting that SRF has a role in the pathogenesis of disease. 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| subjects | 631/208/200 631/45/612/1229 692/699 692/700/139/422 Animals Biological and medical sciences Biotechnology CArG box DNA - genetics DNA - metabolism Fundamental and applied biological sciences. Psychology Humans Investigative techniques, diagnostic techniques (general aspects) knockout Laboratory Medicine Medical sciences Medicine Medicine & Public Health Mice mouse Muscle Contraction - genetics pathobiology-in-focus Pathology Regulatory Sequences, Nucleic Acid serum response factor Serum Response Factor - genetics Serum Response Factor - metabolism Serum Response Factor - physiology Transcription Factors - genetics |
| title | Role of serum response factor in the pathogenesis of disease |
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