Genome-Linked Toxic Responses to Dietary Iron Overload

Genome-related differences to Fe overload between and within rodent species were evaluated in the present study. Male B6C3F, mice, yellow and black C5YSF1 mice, and Fischer 344 (F344) rats were fed AIN-76A diets containing 35 (control), 1,500, 3,500, 5,000, or 10,000 μg carbonyl Fe/g for 12 wk. No e...

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Veröffentlicht in:	Toxicologic pathology 1997-11, Vol.25 (6), p.556-564
Hauptverfasser:	Whittaker, Paul, Dunkel, Virginia C., Bucci, Thomas J., Kusewitt, Donna F, Thurman, J. Dale, Warbritton, Alan, Wolff, George L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atrophy - chemically induced Biological and medical sciences Body Weight - drug effects Chemical and industrial products toxicology. Toxic occupational diseases Female Genome Genotype Heart - drug effects Hypertrophy - chemically induced Iron Overload - genetics Iron, Dietary - toxicity Islets of Langerhans - drug effects Islets of Langerhans - metabolism Islets of Langerhans - pathology Kidney - drug effects Kidney - pathology Liver - drug effects Liver - metabolism Liver - pathology Male Medical sciences Metals and various inorganic compounds Mice Mice, Inbred C3H Mice, Inbred C57BL Organ Size - drug effects Pancreas - drug effects Pancreas - metabolism Pancreas - pathology Rats Rats, Inbred F344 Spleen - drug effects Toxicology
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