Local prolactin is a target to prevent expansion of basal/stem cells in prostate tumors

Androgen-independent recurrence is the major limit of androgen ablation therapy for prostate cancer. Identification of alternative pathways promoting prostate tumor growth is thus needed. Stat5 has been recently shown to promote human prostate cancer cell survival/proliferation and to be associated...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-08, Vol.107 (34), p.15199-15204
Hauptverfasser:	Rouet, Vincent, Bogorad, Roman L., Kayser, Christine, Kessal, Karima, Genestie, Catherine, Bardier, Armelle, Grattan, David R., Kelder, Bruce, Kopchick, John J., Kelly, Paul A., Goffin, Vincent, Baxter, John D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgens Animals Antigens Base Sequence Biological Sciences Cancer Cell growth Cell Proliferation DNA Primers - genetics Epithelial cells Histology Humans Lesions Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred CBA Mice, Transgenic Neoplasms, Hormone-Dependent - genetics Neoplasms, Hormone-Dependent - metabolism Neoplasms, Hormone-Dependent - pathology Neoplasms, Hormone-Dependent - therapy Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Peptide Fragments - genetics Peptide Fragments - metabolism Phenotypes Prolactin - genetics Prolactin - metabolism Prostate Prostate - metabolism Prostate - pathology Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Prostatic Neoplasms - therapy Rats Receptors, Prolactin - antagonists & inhibitors Recombinant Proteins - genetics Recombinant Proteins - metabolism Rodents Signal Transduction STAT5 Transcription Factor - metabolism Stem cells Tissue Distribution Tumors
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