High-throughput retroviral tagging to identify components of specific signaling pathways in cancer

Genetic screens carried out in lower organisms such as yeast, Drosophila melanogaster and Caenorhabditis elegans have revealed many signaling pathways. For example, components of the RAS signaling cascade were identified using a mutant eye phenotype in D. melanogaster as a readout. Screening is usua...

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Veröffentlicht in:	Nature genetics 2002-09, Vol.32 (1), p.153-159
Hauptverfasser:	Allen, John, Berns, Anton, Vink, Edwin, Mikkers, Harald, Hart, Augustinus, Romeyn, Lieke, Knipscheer, Puck
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animal Genetics and Genomics Animals Biological and medical sciences Biomedical and Life Sciences Biomedicine Caenorhabditis elegans Cancer Research Cell Transformation, Neoplastic - genetics Diverse techniques Drosophila melanogaster Fundamental and applied biological sciences. Psychology Gene expression Gene Function Gene mutations Genes Genes, myc Genetic screening Genetics Genomes Health aspects Human Genetics Identification and classification Kinases letter Lymphoma Lymphoma - genetics Lymphoma - physiopathology Mammals Methods Mice Mice, Transgenic Molecular and cellular biology Molecular Sequence Data Mutagenesis Mutation Physiological aspects Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - physiology Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - physiology Proto-Oncogene Proteins c-pim-1 Proviruses - genetics Retroviridae - genetics Signal Transduction Tumors Virus Integration Yeasts
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