Cortical spreading depression causes and coincides with tissue hypoxia

Cortical spreading depression (CSD) is a self-propagating wave of cellular depolarization that has been implicated in migraine and in progressive neuronal injury after stroke and head trauma. Using two-photon microscopic NADH imaging and oxygen sensor microelectrodes in live mouse cortex, we find th...

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Veröffentlicht in:	Nature neuroscience 2007-06, Vol.10 (6), p.754-762
Hauptverfasser:	Takano, Takahiro, Tian, Guo-Feng, Peng, Weiguo, Lou, Nanhong, Lovatt, Ditte, Hansen, Anker J, Kasischke, Karl A, Nedergaard, Maiken
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Genetics and Genomics Animals Astrocytes - metabolism Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Brain Edema - etiology Cerebral Cortex - metabolism Cerebral Cortex - pathology Cerebral Cortex - physiopathology Cerebrovascular Circulation Cortical Spreading Depression - drug effects Cortical Spreading Depression - physiology Diagnosis Diagnostic Imaging Electroencephalography - methods Female Hypoxia Hypoxia - pathology Hypoxia - physiopathology Laser-Doppler Flowmetry - methods Luminescent Proteins - biosynthesis Male Membrane Potentials - physiology Metabolism Mice Mice, Transgenic Microscopy Migraine NAD Neurobiology Neurons Neurons - metabolism Neurosciences Oxygen - metabolism Oxygen - pharmacology Patch-Clamp Techniques Physiological aspects Physiology Risk factors Tissues
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