Early Patterns of Verbal Memory Impairment in Children Treated for Medulloblastoma
Children treated for medulloblastoma demonstrate a variety of cognitive deficits in addition to white matter and hippocampal neuropathology. This study examined 40 children treated for medulloblastoma as compared with 40 demographically matched controls on the California Verbal Learning Test-Childre...
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| Veröffentlicht in: | Neuropsychology 2006-01, Vol.20 (1), p.105-112 |
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| creator | Nagel, Bonnie J Delis, Dean C Palmer, Shawna L Reeves, Cara Gajjar, Amar Mulhern, Raymond K |
| description | Children treated for medulloblastoma demonstrate a variety of cognitive deficits in addition to white matter and hippocampal neuropathology. This study examined 40 children treated for medulloblastoma as compared with 40 demographically matched controls on the California Verbal Learning Test-Children's Version (
D. C. Delis, J. H. Kramer, E. Kaplan, & B. A. Ober, 1994
). Results revealed significantly poorer performance on indices of word recall in the patient group as compared with the controls in addition to milder but still significantly poorer recognition memory. These findings suggest that children treated for medulloblastoma demonstrate a mixed profile of memory impairment consisting of both retrieval and recognition deficits. Implications of these findings for understanding neurobehavioral sequelae within pediatric medulloblastoma populations and for designing educational and remediation strategies to be used with these children are discussed. |
| doi_str_mv | 10.1037/0894-4105.20.1.105 |
| format | Article |
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D. C. Delis, J. H. Kramer, E. Kaplan, & B. A. Ober, 1994
). Results revealed significantly poorer performance on indices of word recall in the patient group as compared with the controls in addition to milder but still significantly poorer recognition memory. These findings suggest that children treated for medulloblastoma demonstrate a mixed profile of memory impairment consisting of both retrieval and recognition deficits. Implications of these findings for understanding neurobehavioral sequelae within pediatric medulloblastoma populations and for designing educational and remediation strategies to be used with these children are discussed.</description><identifier>ISSN: 0894-4105</identifier><identifier>EISSN: 1931-1559</identifier><identifier>DOI: 10.1037/0894-4105.20.1.105</identifier><identifier>PMID: 16460226</identifier><identifier>CODEN: NEUPEG</identifier><language>eng</language><publisher>Washington, DC: American Psychological Association</publisher><subject>Adolescent ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Biological and medical sciences ; Brain Neoplasms ; Cerebellar Neoplasms - drug therapy ; Cerebellar Neoplasms - psychology ; Cerebellar Neoplasms - radiotherapy ; Child ; Child clinical studies ; Child, Preschool ; Cognitive Impairment ; Combined Modality Therapy ; Cranial Irradiation - adverse effects ; Dose-Response Relationship, Radiation ; Female ; Hippocampus ; Hippocampus - pathology ; Hippocampus - radiation effects ; Human ; Humans ; Infant ; Intelligence - radiation effects ; Male ; Medical sciences ; Medulloblastoma - drug therapy ; Medulloblastoma - psychology ; Medulloblastoma - radiotherapy ; Mental Recall - radiation effects ; Neoadjuvant Therapy ; Neuropathology ; Neuropsychological Tests ; Organic mental disorders. Neuropsychology ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Radiation Injuries - diagnosis ; Radiation Injuries - psychology ; Reference Values ; Topotecan - administration & dosage ; Verbal Learning - radiation effects ; Verbal Memory ; Vocabulary ; Wechsler Scales</subject><ispartof>Neuropsychology, 2006-01, Vol.20 (1), p.105-112</ispartof><rights>2006 American Psychological Association</rights><rights>2006 INIST-CNRS</rights><rights>2006, American Psychological Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a418t-e816e5a44d692fab6a17e387e07869a86958910b8471a36bf6fe523a8d8990483</citedby><cites>FETCH-LOGICAL-a418t-e816e5a44d692fab6a17e387e07869a86958910b8471a36bf6fe523a8d8990483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17476428$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16460226$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nagel, Bonnie J</creatorcontrib><creatorcontrib>Delis, Dean C</creatorcontrib><creatorcontrib>Palmer, Shawna L</creatorcontrib><creatorcontrib>Reeves, Cara</creatorcontrib><creatorcontrib>Gajjar, Amar</creatorcontrib><creatorcontrib>Mulhern, Raymond K</creatorcontrib><title>Early Patterns of Verbal Memory Impairment in Children Treated for Medulloblastoma</title><title>Neuropsychology</title><addtitle>Neuropsychology</addtitle><description>Children treated for medulloblastoma demonstrate a variety of cognitive deficits in addition to white matter and hippocampal neuropathology. This study examined 40 children treated for medulloblastoma as compared with 40 demographically matched controls on the California Verbal Learning Test-Children's Version (
D. C. Delis, J. H. Kramer, E. Kaplan, & B. A. Ober, 1994
). Results revealed significantly poorer performance on indices of word recall in the patient group as compared with the controls in addition to milder but still significantly poorer recognition memory. These findings suggest that children treated for medulloblastoma demonstrate a mixed profile of memory impairment consisting of both retrieval and recognition deficits. Implications of these findings for understanding neurobehavioral sequelae within pediatric medulloblastoma populations and for designing educational and remediation strategies to be used with these children are discussed.</description><subject>Adolescent</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Brain Neoplasms</subject><subject>Cerebellar Neoplasms - drug therapy</subject><subject>Cerebellar Neoplasms - psychology</subject><subject>Cerebellar Neoplasms - radiotherapy</subject><subject>Child</subject><subject>Child clinical studies</subject><subject>Child, Preschool</subject><subject>Cognitive Impairment</subject><subject>Combined Modality Therapy</subject><subject>Cranial Irradiation - adverse effects</subject><subject>Dose-Response Relationship, Radiation</subject><subject>Female</subject><subject>Hippocampus</subject><subject>Hippocampus - pathology</subject><subject>Hippocampus - radiation effects</subject><subject>Human</subject><subject>Humans</subject><subject>Infant</subject><subject>Intelligence - radiation effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medulloblastoma - drug therapy</subject><subject>Medulloblastoma - psychology</subject><subject>Medulloblastoma - radiotherapy</subject><subject>Mental Recall - radiation effects</subject><subject>Neoadjuvant Therapy</subject><subject>Neuropathology</subject><subject>Neuropsychological Tests</subject><subject>Organic mental disorders. Neuropsychology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Radiation Injuries - diagnosis</subject><subject>Radiation Injuries - psychology</subject><subject>Reference Values</subject><subject>Topotecan - administration & dosage</subject><subject>Verbal Learning - radiation effects</subject><subject>Verbal Memory</subject><subject>Vocabulary</subject><subject>Wechsler Scales</subject><issn>0894-4105</issn><issn>1931-1559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkMFq3DAQhkVIaTZpXyCHIELbm1NJlmT5GJZtupDSELa9irE9Jg6y5Uj2Yd--MrtkoQch-Pjmn-En5JqzO87y4jszpcwkZ-pOJJKYOiMrXuY840qV52T1LlyQyxhfGUtAq4_kgmupmRB6RZ43ENyePsE0YRgi9S39i6ECR39h78OebvsRutDjMNFuoOuXzjUBB7oLCBM2tPUhmc3snK8cxMn38Il8aMFF_Hz8r8ifH5vd-mf2-Pthu75_zEByM2VouEYFUja6FC1UGniBuSmQFUaXkJ4yJWeVkQWHXFetblGJHExjypJJk1-Rb4fcMfi3GeNk-y7W6BwM6OdojdKKC5Un8fY_8dXPYUi3Wc2lVFyxJU0cpDr4GAO2dgxdD2FvObNL3XZp0y5tWpFIYioN3RyT56rH5jRy7DcJX48CxBpcG2Cou3jyClloKZbtXw4ejGDHuK8hTF3tMNoB59O-fzFyklk</recordid><startdate>200601</startdate><enddate>200601</enddate><creator>Nagel, Bonnie J</creator><creator>Delis, Dean C</creator><creator>Palmer, Shawna L</creator><creator>Reeves, Cara</creator><creator>Gajjar, Amar</creator><creator>Mulhern, Raymond K</creator><general>American Psychological Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7RZ</scope><scope>PSYQQ</scope><scope>7T9</scope></search><sort><creationdate>200601</creationdate><title>Early Patterns of Verbal Memory Impairment in Children Treated for Medulloblastoma</title><author>Nagel, Bonnie J ; Delis, Dean C ; Palmer, Shawna L ; Reeves, Cara ; Gajjar, Amar ; Mulhern, Raymond K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a418t-e816e5a44d692fab6a17e387e07869a86958910b8471a36bf6fe523a8d8990483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adolescent</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Brain Neoplasms</topic><topic>Cerebellar Neoplasms - drug therapy</topic><topic>Cerebellar Neoplasms - psychology</topic><topic>Cerebellar Neoplasms - radiotherapy</topic><topic>Child</topic><topic>Child clinical studies</topic><topic>Child, Preschool</topic><topic>Cognitive Impairment</topic><topic>Combined Modality Therapy</topic><topic>Cranial Irradiation - adverse effects</topic><topic>Dose-Response Relationship, Radiation</topic><topic>Female</topic><topic>Hippocampus</topic><topic>Hippocampus - pathology</topic><topic>Hippocampus - radiation effects</topic><topic>Human</topic><topic>Humans</topic><topic>Infant</topic><topic>Intelligence - radiation effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medulloblastoma - drug therapy</topic><topic>Medulloblastoma - psychology</topic><topic>Medulloblastoma - radiotherapy</topic><topic>Mental Recall - radiation effects</topic><topic>Neoadjuvant Therapy</topic><topic>Neuropathology</topic><topic>Neuropsychological Tests</topic><topic>Organic mental disorders. Neuropsychology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Radiation Injuries - diagnosis</topic><topic>Radiation Injuries - psychology</topic><topic>Reference Values</topic><topic>Topotecan - administration & dosage</topic><topic>Verbal Learning - radiation effects</topic><topic>Verbal Memory</topic><topic>Vocabulary</topic><topic>Wechsler Scales</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nagel, Bonnie J</creatorcontrib><creatorcontrib>Delis, Dean C</creatorcontrib><creatorcontrib>Palmer, Shawna L</creatorcontrib><creatorcontrib>Reeves, Cara</creatorcontrib><creatorcontrib>Gajjar, Amar</creatorcontrib><creatorcontrib>Mulhern, Raymond K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>APA PsycArticles®</collection><collection>ProQuest One Psychology</collection><collection>Linguistics and Language Behavior Abstracts (LLBA)</collection><jtitle>Neuropsychology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nagel, Bonnie J</au><au>Delis, Dean C</au><au>Palmer, Shawna L</au><au>Reeves, Cara</au><au>Gajjar, Amar</au><au>Mulhern, Raymond K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early Patterns of Verbal Memory Impairment in Children Treated for Medulloblastoma</atitle><jtitle>Neuropsychology</jtitle><addtitle>Neuropsychology</addtitle><date>2006-01</date><risdate>2006</risdate><volume>20</volume><issue>1</issue><spage>105</spage><epage>112</epage><pages>105-112</pages><issn>0894-4105</issn><eissn>1931-1559</eissn><coden>NEUPEG</coden><abstract>Children treated for medulloblastoma demonstrate a variety of cognitive deficits in addition to white matter and hippocampal neuropathology. This study examined 40 children treated for medulloblastoma as compared with 40 demographically matched controls on the California Verbal Learning Test-Children's Version (
D. C. Delis, J. H. Kramer, E. Kaplan, & B. A. Ober, 1994
). Results revealed significantly poorer performance on indices of word recall in the patient group as compared with the controls in addition to milder but still significantly poorer recognition memory. These findings suggest that children treated for medulloblastoma demonstrate a mixed profile of memory impairment consisting of both retrieval and recognition deficits. Implications of these findings for understanding neurobehavioral sequelae within pediatric medulloblastoma populations and for designing educational and remediation strategies to be used with these children are discussed.</abstract><cop>Washington, DC</cop><pub>American Psychological Association</pub><pmid>16460226</pmid><doi>10.1037/0894-4105.20.1.105</doi><tpages>8</tpages></addata></record> |
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| subjects | Adolescent Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Brain Neoplasms Cerebellar Neoplasms - drug therapy Cerebellar Neoplasms - psychology Cerebellar Neoplasms - radiotherapy Child Child clinical studies Child, Preschool Cognitive Impairment Combined Modality Therapy Cranial Irradiation - adverse effects Dose-Response Relationship, Radiation Female Hippocampus Hippocampus - pathology Hippocampus - radiation effects Human Humans Infant Intelligence - radiation effects Male Medical sciences Medulloblastoma - drug therapy Medulloblastoma - psychology Medulloblastoma - radiotherapy Mental Recall - radiation effects Neoadjuvant Therapy Neuropathology Neuropsychological Tests Organic mental disorders. Neuropsychology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Radiation Injuries - diagnosis Radiation Injuries - psychology Reference Values Topotecan - administration & dosage Verbal Learning - radiation effects Verbal Memory Vocabulary Wechsler Scales |
| title | Early Patterns of Verbal Memory Impairment in Children Treated for Medulloblastoma |
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